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Research Roundup: Aug 16, 2021



The CV Sciences medical adviser Dr. Jamie Corroon on using CBD to lessen the anxiety that can be caused by THC

https://uproxx.com/life/how-to-smoke-weed-without-paranoia-guide/



Best of the Week...


In humans with Dravet syndrome, CBD caused therapeutic effects within two weeks

Time to onset of cannabidiol treatment effects in Dravet syndrome: Analysis from two randomized controlled trials

https://pubmed.ncbi.nlm.nih.gov/34265088/


This review looks at the use of CBD for anxiety, pain & inflammation in dogs, cats & companion animals

Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation

https://www.sciencedirect.com/science/article/abs/pii/S0034528821002538


In skin tissue, CBD protected the skin stem cells exposed to toxic hydrogen peroxide by reducing stress & maintaining the protein regulation networks

Protective effects of cannabidiol on the membrane proteins of skin keratinocytes exposed to hydrogen peroxide via participation in the proteostasis network

https://pubmed.ncbi.nlm.nih.gov/34298466/


In mice with oral ulcers (a common side effect of radiation therapy for cancer), CBD accelerated healing & lessened inflammation partially via the regulation of genetic transcription

CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome

https://pubmed.ncbi.nlm.nih.gov/34269108/


Guzmán’s team finds a new modulator of the CB1 receptor: BiP

Identification of BiP as a CB 1 receptor-interacting protein that fine-tunes cannabinoid signaling in the mouse brain

https://pubmed.ncbi.nlm.nih.gov/34353897/


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

In humans, CBD did not decrease reaction times in a visual stimulus test

The effect of cannabidiol (CBD) on simple and complex reaction times

http://www.tss.awf.poznan.pl/files/2021/Vol%2028%20no%202/8_Skopek_TSS_2021_282_147-151.pdf


This reviews looks at using CBD for the early stages of psychosis

Cannabidiol (CBD) as a novel treatment in the early phases of psychosis

https://pubmed.ncbi.nlm.nih.gov/34255100/


In a case study of a man with schizophrenia & substance use disorder, high CBD-low THC cigarettes helped lessen his cannabis use & stop his cocaine use

Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder

https://pubmed.ncbi.nlm.nih.gov/34366942/


In humans with epilepsy, CBD caused positive changes in their EEG patterns relating to interictal epileptiform discharge frequency

Longitudinal impact of cannabidiol on EEG measures in subjects with treatment-resistant epilepsy

https://pubmed.ncbi.nlm.nih.gov/34273739/


In this case study of someone with Tourette syndrome, a nabiximol (1:1 THC:CBD medicine) caused a reduction of tics

Tic Reduction in Adult Onset Gilles De La Tourette Syndrome Using as Required Nabiximols Spray

https://tremorjournal.org/articles/10.5334/tohm.613/


In men, a single session of moderate exercise improved memory & increased the levels of anandamide as well as BDNF (the brain growth factor)

A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men

https://pubmed.ncbi.nlm.nih.gov/34257382/


A review of nabiximols for cannabis use disorder

Nabiximols as a substitute for cannabis

https://pubmed.ncbi.nlm.nih.gov/33201625/


A survey of cancer patients using CBD

Cannabidiol: Knowledge, Beliefs, and Experiences of Patients With Cancer

https://pubmed.ncbi.nlm.nih.gov/34269337/


This review of cannabinoids for inflammation & oxidative stress find the preclinical work to be promising but that the clinical work still needs to be done

The Therapeutic Potential of Cannabis in Counteracting Oxidative Stress and Inflammation

https://pubmed.ncbi.nlm.nih.gov/34361704/


A review of 11 studies looks at THC & CBD for schizophrenia

The Impact of THC and CBD in Schizophrenia: A Systematic Review

https://pubmed.ncbi.nlm.nih.gov/34366924/


A review of cannabinoids for cancer

Cannabinoids in the landscape of cancer

https://pubmed.ncbi.nlm.nih.gov/34259916/


A review of cannabinoids for melanoma (aggressive skin cancer)

Cannabinoids and their derivatives in struggle against melanoma

https://pubmed.ncbi.nlm.nih.gov/34264513/


This review looks at the activity of endocannabinoids outside of their actions at the cannabinoid receptors

Noncanonical Activity of Endocannabinoids and Their Receptors in Central and Peripheral Synapses

https://pubmed.ncbi.nlm.nih.gov/34284706/



Preclinical Research & Cannabinoid Chemistry

In a tissue culture of canine bladder cancer, CBD caused apoptosis (programmed cellular suicide)

Combination therapy with cannabidiol and chemotherapeutics in canine urothelial carcinoma cells

https://pubmed.ncbi.nlm.nih.gov/34352013/


In mice with adolescent exposure to alcohol, an enriched environment helped to restore their synaptic plasticity via their cannabinoid & glutamate receptors

Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence

https://pubmed.ncbi.nlm.nih.gov/34356889/


In a mouse model of chronic unpredictable stress, the analgesic drug dipyrone may exert its effects via the ECS & the TRPV1 receptor (which is activated by anandamide)

The role of endocannabinoid system and TRPV1 receptors in the antidepressant and anxiolytic effects of dipyrone in chronic unpredictable mild stress in mice

https://pubmed.ncbi.nlm.nih.gov/34270988/


In the brain of a model organism, the injection of PEA or OEA mediated the brain levels of serotonin & acetylcholine

In vivo brain levels of acetylcholine and 5-hydroxytryptamine after oleoylethanolamide or palmitoylethanolamide administrations are mediated by PPARα engagement

https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.15409


In rat livers, NSAIDs act as inhibitors of the FAAH enzyme & that may be part of the reason for their modulation of pain

Assessment of NSAIDS as Potential Inhibitors of the Fatty Acid Amide Hydrolase I (FAAH-1) using Three Different Primary Fatty Acid Amide Substrates In Vitro

https://assets.researchsquare.com/files/rs-728085/v1/9d99d13a-44b8-4acf-9e76-d8ce70ae8584.pdf?c=1628260454


In human skin tissue, activating the CB2 receptor helped with wound healing & the reduction of fibrosis (scarring)

Targeting cannabinoid receptor 2 (CB2) limits collagen production - an in vitro study in a primary culture of human fibroblasts

https://pubmed.ncbi.nlm.nih.gov/34259358/


In mice with a hole in their intestines, activating the CB2 receptor protected from inflammation & sepsis

Activation of CB2 receptor inhibits pyroptosis and subsequently ameliorates cecal ligation and puncture-induced sepsis

https://pubmed.ncbi.nlm.nih.gov/34364304/


In guinea pigs (a common model organism for ears), activating the CB2 receptor helped with cochlear inflammation caused by an endotoxic bacteria

Cannabinoid Receptor 2 Agonism is Capable of Preventing Lipopolysaccharide Induced Decreases of Cochlear Microcirculation - A Potential Approach for Inner Ear Pathologies

https://pubmed.ncbi.nlm.nih.gov/34267099/


In mice with asthma, β-caryophyllene (usually the most common terpene in hemp) altered the balance of T-cells & lowering the lung inflammation

Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice

https://pubmed.ncbi.nlm.nih.gov/34277815/


In female mice, how the activation of the CB1 receptor alters their hormone levels

Expression of type one cannabinoid receptor in different subpopulation of kisspeptin neurons and kisspeptin afferents to GnRH neurons in female mice

https://pubmed.ncbi.nlm.nih.gov/34263407/


In the retinas of goldfish, the CB1 receptor & a dopamine receptor work together to modulate the day/night difference in rod-cone coupling

Interactions of cone cannabinoid CB1 and dopamine D4 receptors increase day/night difference in rod-cone gap junction coupling in goldfish retina

https://pubmed.ncbi.nlm.nih.gov/34252195/


A review of the design for new modulators of the CB1 receptors

Molecular basis for ligand modulation of the cannabinoid receptor CB1

https://pubmed.ncbi.nlm.nih.gov/34265078/