The CV Sciences medical adviser Dr. Jamie Corroon on using CBD to lessen the anxiety that can be caused by THC
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In humans with Dravet syndrome, CBD caused therapeutic effects within two weeks
Time to onset of cannabidiol treatment effects in Dravet syndrome: Analysis from two randomized controlled trials
This review looks at the use of CBD for anxiety, pain & inflammation in dogs, cats & companion animals
Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation
In skin tissue, CBD protected the skin stem cells exposed to toxic hydrogen peroxide by reducing stress & maintaining the protein regulation networks
Protective effects of cannabidiol on the membrane proteins of skin keratinocytes exposed to hydrogen peroxide via participation in the proteostasis network
In mice with oral ulcers (a common side effect of radiation therapy for cancer), CBD accelerated healing & lessened inflammation partially via the regulation of genetic transcription
CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome
Guzmán’s team finds a new modulator of the CB1 receptor: BiP
Identification of BiP as a CB 1 receptor-interacting protein that fine-tunes cannabinoid signaling in the mouse brain
Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)
In humans, CBD did not decrease reaction times in a visual stimulus test
The effect of cannabidiol (CBD) on simple and complex reaction times
This reviews looks at using CBD for the early stages of psychosis
Cannabidiol (CBD) as a novel treatment in the early phases of psychosis
In a case study of a man with schizophrenia & substance use disorder, high CBD-low THC cigarettes helped lessen his cannabis use & stop his cocaine use
Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder
In humans with epilepsy, CBD caused positive changes in their EEG patterns relating to interictal epileptiform discharge frequency
Longitudinal impact of cannabidiol on EEG measures in subjects with treatment-resistant epilepsy
In this case study of someone with Tourette syndrome, a nabiximol (1:1 THC:CBD medicine) caused a reduction of tics
Tic Reduction in Adult Onset Gilles De La Tourette Syndrome Using as Required Nabiximols Spray
In men, a single session of moderate exercise improved memory & increased the levels of anandamide as well as BDNF (the brain growth factor)
A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men
A review of nabiximols for cannabis use disorder
Nabiximols as a substitute for cannabis
A survey of cancer patients using CBD
Cannabidiol: Knowledge, Beliefs, and Experiences of Patients With Cancer
This review of cannabinoids for inflammation & oxidative stress find the preclinical work to be promising but that the clinical work still needs to be done
The Therapeutic Potential of Cannabis in Counteracting Oxidative Stress and Inflammation
A review of 11 studies looks at THC & CBD for schizophrenia
The Impact of THC and CBD in Schizophrenia: A Systematic Review
A review of cannabinoids for cancer
Cannabinoids in the landscape of cancer
A review of cannabinoids for melanoma (aggressive skin cancer)
Cannabinoids and their derivatives in struggle against melanoma
This review looks at the activity of endocannabinoids outside of their actions at the cannabinoid receptors
Noncanonical Activity of Endocannabinoids and Their Receptors in Central and Peripheral Synapses
Preclinical Research & Cannabinoid Chemistry
In a tissue culture of canine bladder cancer, CBD caused apoptosis (programmed cellular suicide)
Combination therapy with cannabidiol and chemotherapeutics in canine urothelial carcinoma cells
In mice with adolescent exposure to alcohol, an enriched environment helped to restore their synaptic plasticity via their cannabinoid & glutamate receptors
Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence
In a mouse model of chronic unpredictable stress, the analgesic drug dipyrone may exert its effects via the ECS & the TRPV1 receptor (which is activated by anandamide)
The role of endocannabinoid system and TRPV1 receptors in the antidepressant and anxiolytic effects of dipyrone in chronic unpredictable mild stress in mice
In the brain of a model organism, the injection of PEA or OEA mediated the brain levels of serotonin & acetylcholine
In vivo brain levels of acetylcholine and 5-hydroxytryptamine after oleoylethanolamide or palmitoylethanolamide administrations are mediated by PPARα engagement
In rat livers, NSAIDs act as inhibitors of the FAAH enzyme & that may be part of the reason for their modulation of pain
Assessment of NSAIDS as Potential Inhibitors of the Fatty Acid Amide Hydrolase I (FAAH-1) using Three Different Primary Fatty Acid Amide Substrates In Vitro
In human skin tissue, activating the CB2 receptor helped with wound healing & the reduction of fibrosis (scarring)
Targeting cannabinoid receptor 2 (CB2) limits collagen production - an in vitro study in a primary culture of human fibroblasts
In mice with a hole in their intestines, activating the CB2 receptor protected from inflammation & sepsis
Activation of CB2 receptor inhibits pyroptosis and subsequently ameliorates cecal ligation and puncture-induced sepsis
In guinea pigs (a common model organism for ears), activating the CB2 receptor helped with cochlear inflammation caused by an endotoxic bacteria
Cannabinoid Receptor 2 Agonism is Capable of Preventing Lipopolysaccharide Induced Decreases of Cochlear Microcirculation - A Potential Approach for Inner Ear Pathologies
In mice with asthma, β-caryophyllene (usually the most common terpene in hemp) altered the balance of T-cells & lowering the lung inflammation
Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice
In female mice, how the activation of the CB1 receptor alters their hormone levels
Expression of type one cannabinoid receptor in different subpopulation of kisspeptin neurons and kisspeptin afferents to GnRH neurons in female mice
In the retinas of goldfish, the CB1 receptor & a dopamine receptor work together to modulate the day/night difference in rod-cone coupling
Interactions of cone cannabinoid CB1 and dopamine D4 receptors increase day/night difference in rod-cone gap junction coupling in goldfish retina
A review of the design for new modulators of the CB1 receptors
Molecular basis for ligand modulation of the cannabinoid receptor CB1