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Research Roundup: May 7, 2024

Best of cannabinoid science this week...

In patients with neuropathic pain, a double-blind placebo trial of oral THC (at 0.2mg/kg) caused significant improvements to inhibitory pain mechanisms & parasympathetic tone

Oral Delta-9-Tetrahydrocannabinol (THC) Increases Parasympathetic Activity and Supraspinal Conditioned Pain Modulation in Chronic Neuropathic Pain Male Patients: A Crossover, Double-Blind, Placebo-Controlled Trial

In people with Alzheimer's disease, a double-blind placebo trial of CBD improved their behavioral symptoms

Cannabidiol for behavior symptoms in Alzheimer's disease (CANBiS-AD): a randomized, double-blind, placebo-controlled trial

For fibromyalgia, a survey found cannabis to be commonly used for pain, fatigue, insomnia, stress, anxiety & depression

A Cross-Sectional Survey Study of Cannabis Use for Fibromyalgia Symptom Management

In people with crack use disorder, ten weeks of CBD helped to reduce crack use with less clinical & psychiatric complaints

Cannabidiol Compared to Pharmacological Treatment as Usual for Crack Use Disorder: A Feasibility, Preliminary Efficacy, Parallel, Double-Blind, Randomized Clinical Trial

In public health data of people presenting with a traumatic brain injury, those who tested positive for cannabis had a higher rate of discharge, shorter hospital stays & better recovery scores

Traumatic Brain Injury Outcomes After Recreational Cannabis Use

In a cat with advanced cancer, a full spectrum cannabis product (4:1 CBD:CBD) relieved their symptoms within a week & gave them six more months of good health & energy until ultimately euthanized for blindness

The Use of Medical Cannabis as Palliative Care in a Feline With Advanced Cancer

A review of the therapeutic use of the cannabinoids (with a nice CBD binding chart)

Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use

For cardiac surgery, a review of using CBD to help with the complications

Exploring the Possible Role of Cannabinoids in Managing Post-Cardiac Surgery Complications: A Narrative Review of Preclinical Evidence and a Call for Future Research Directions

For pain, a review of nine recent randomized clinical trials using cannabis

The clinical use of cannabinoids for pain

In people living with HIV, a review found little evidence for cannabis use causing harmful cognitive effects

The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies And in a mouse model of HIV, acute CBD had no effect on their behavior or endocannabinoid system

Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice

For cannabinoid oral health products, a review of 15 articles on their anti-cavity & anti-gingivitis properties

Anticaries and Antigingivitis Properties of Cannabinoid-Containing Oral Health Products: A Review

And in mouth cells, CBD & CBG improved their viability, increased anti-inflammatory mediators & acted as an antibiotic against the S. mutans bacteria that contributes to tooth decay

Antibiofilm and Immune-Modulatory Activity of Cannabidiol and Cannabigerol in Oral Environments-In Vitro Study

For Alzheimer's disease, a review of endocannabinoid targets to modulate the disease (good charts)

Potential Therapeutic Targets to Modulate the Endocannabinoid System in Alzheimer's Disease

And in a mouse model of Alzheimer's disease, CBD improved cognitive function via the microbiome & gut-brain axis

Cannabidiol improves the cognitive function of SAMP8 AD model mice involving the microbiota-gut-brain axis

In a rat model of migraines, CBD worked roughly as well as the pharmaceutical treatment drugs sumatriptan & cafiaspirin

Study on the Effects of Isolated Cannabidiol on Vascular Cephalalgia in an Experimental Model of Induced Migraine in Wistar Rats

In a mouse model of fragile X syndrome, the beneficial effects of CBD for rescuing cognitive deficits seem to be mediated by the GPR55 receptor (which may one day be known as CB3) as well as competition for the fatty acid binding protein (FABP1, a (putative) transporter of endocannabinoids)

Cannabidiol and positive effects on object recognition memory in an in vivo model of Fragile X Syndrome: Obligatory role of hippocampal GPR55 receptors

In a rat model of diabetic Parkinson's disease, CBD nanoparticles lessened metabolic & memory impairments via the modulation of dopamine levels & changes to the hippocampus (memory center of the brain)

Assessing the Safety and Therapeutic Efficacy of Cannabidiol Lipid Nanoparticles in Alleviating Metabolic and Memory Impairments and Hippocampal Histopathological Changes in Diabetic Parkinson's Rats

In juvenile rats born to obese mothers, CBD protected against the behavioral, neuroinflammatory & neurochemical dysfunctions that arose in their juvenile years

Cannabidiol improves maternal obesity-induced behavioral, neuroinflammatory and neurochemical dysfunctions in the juvenile offspring

In a skin stem cell model of inflammation, CBD & beta caryophyllene acted as anti-inflammatory agents with more efficacy when administered together, acting via the regulation of genetic expression

Anti-Inflammatory Properties of Cannabidiol and Beta-Caryophyllene Alone or Combined in an In Vitro Inflammation Model

Cannabis extracts as an antimicrobial against MRSA (the treatment resistant staph infection that haunts hospitals & kills more people than HIV)

Antimicrobial and antibiofilm effect of cannabinoids from Cannabis sativa against methicillin-resistant Staphylococcus aureus (MRSA) causing bovine mastitis

And on using CBD as an antibiotic against Staphylococcus aureus



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