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Research Roundup: May 14, 2024



Best of cannabinoid science this week...


In people with multiple sclerosis, 12 weeks of nabiximols (1:1 THC:CBD spray) improved gait speed, spasticity, pain, sleep quality, urinary bladder dysfunction & overall goals

Patient-reported benefits from nabiximols treatment in multiple sclerosis-related spasticity exceed conventional measures


In people with dementia causing aggression & agitation, THC edibles improved their neuropsychiatric symptoms with notably few adverse reactions (and reductions or discontinuations of antipsychotic medications)

“From Stigma to Solution” – Using THC Edibles for the Palliative Treatment of Aggression and Agitation in Dementia


In an open-label trial of cannabis use by people with neurodegenerative disorders, the participants experienced reduced pain, improved sleep, less agitation and percent enhanced well-being

Medicinal cannabis in neurodegenerative disorders: an open label, dose finding, safety and efficacy study


In people with advanced cancer receiving palliative care, those who used cannabis most frequently reported improvements to their pain, sleep & mood with fatigue, nausea & cognitive impairment being the most frequently mentioned adverse effect

Preliminary Results from a Phase IV Surveillance Study of Medical Cannabis Use in Australian Patients With Advanced Cancer Receiving Palliative Care


In people with temporomandibular joint disorders (painful condition of the jaw joints & muscles), both CBD cream & a CBD vape improved pain as well as stress & anxiety

Clinical Study of Analgesic and Anti-inflammatory Properties of Cannabis Derivatives in Patients with Temporomandibular Joint Pathology: Preliminary Study


In two pilot studies of THC or 1:1 THC:CBD for neuropathic pain, a month of treatment improved pain levels & sleep

Analgesic Effect of delta-9-Tetrahydrocannabinol Alone and of a 1:1 delta-9-Tetrahydrocannabinol: Cannabidiol Formulation in Chronic Neuropathic Pain: Two Pilot Studies


In exercising adults, 100 milligrams of CBD per day helped with pain scores

THE EFFECTS OF A BRAND-SPECIFIC HEMP-DERIVED CANNABIDIOL PRODUCT IN HEALTHY ADULTS


In people in early recovery from opioid or stimulant addiction, the benefits of cannabis substitution

"Everything is kind of the same except my mind is with me": exploring cannabis substitution in a sample of adults in early recovery from an opioid or stimulant addiction


In dogs with mobility disorders, a double-blind placebo study found that those receiving CBD oil improved on both subjective & objective outcome measures & that it combined safely with NSAIDs, though a third of the dogs experienced liver enzyme elevations

Evaluation of the Effect of Cannabidiol Administration with and without Nonsteroidal Anti-inflammatory Drugs in Dogs with Mobility Disorders: A Prospective, Double-blind, Crossover, Placebo-controlled Study


On using PEA for chronic pain in geriatric cats [Portuguese]

Desenvolvimento de uma pasta veterinária enriquecida com palmitoiletanolamida destinada ao manejo da dor crônica em felinos geriátricos


A meta-analysis of CBD bioavailability studies found better absorption after being fed

Cannabidiol Bioavailability Is Nonmonotonic with a Long Terminal Elimination Half-Life: A Pharmacokinetic Modeling-Based Analysis

And in dogs, a comparison of three oil & one semi-solid CBD preparation

Pharmacokinetics behavior of four cannabidiol preparations following single oral administration in dogs


A review of studies on athletes using CBD to modulate their inflammation & immune system via microRNA [regulators of genetic expression]

Action of cannabidiol in interaction with microRNAs and exosomes in modulation of inflammatory and immune processes in athletes: a systematic review

And a review of aerobic exercise reducing stress via the endocannabinoid system

An Update on Role of Aerobic Exercise and Endocannabinoids Over Stress Controlling Along with Brain Reward System: A Narrative Reviews


A review of why to use cannabinoids for acute pain

Cannabinoids for Acute Pain Management: Approaches and Rationale

And a review on using PEA as a painkiller

Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain


A review of treating sleep disorders with cannabis

A new approach to treating sleep disorders? - Medical marijuana review


A review of using cannabinoids to treat Parkinson's disease & cancer

Cannabinoids in the treatment of Parkinson’s Disease and Cancer: An updated review


A review of the terpene α-humulene

The Clinical Translation of α-humulene - A Scoping Review


In a mouse model of PTSD, cannabis oil improved anxiety & depressive symptoms via the BDNF/TRPC6 signaling pathway

Medicinal cannabis oil improves anxiety-like and depressive-like behaviors in CCS mice via the BDNF/TRPC6 signaling pathway


In an animal model of seizures, CBC & CBN from hemp extracts cause anti-seizure effects, the former via the GABA receptors

Cannabichromene from full-spectrum hemp extract exerts acute anti-seizure effects through allosteric activation of GABAA receptors


In a mouse model of Alzheimer's disease, both the vaping of cannabis as well as JWH-133 (which binds to the CB2 receptor) reduced anxiety, cognitive deficits & brain plaques

Exploring Cannabinoids with Enhanced Binding Affinity for Targeting the Expanded Endocannabinoid System: A Promising Therapeutic Strategy for Alzheimer's Disease Treatment


The molecular pathways of the endocannabinoid system linking COVID-19 to Alzheimer's disease onset/progression

Probing molecular pathways: Illuminating the connection between COVID-19 and Alzheimer's disease through the endocannabinoid system dynamics


A thesis project on how CBD causes its antioxidant effect via the Keap1-Nrf2 pathway

Investigating the Potential Therapeutic Effects of CBD in Vitro


In a mouse model of knee osteoarthritis, THC helped with pain & disease modification

ORAL GAVAGE OF DELTA-9-TETRAHYDROCANNABINOL PROVIDES PAIN AND DISEASE MODIFICATION IN MOUSE MODELS OF KNEE OSTEOARTHRITIS

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