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Research Roundup: Apr 23, 2024



Best of cannabinoid science this week...



In Thailand’s first trial of CBD oil for insomnia, sublingual CBD treatment improved sleep duration, sleep maintenance, sleep induction, quality of life & daytime sleepiness

Efficacy and Safety of Cannabidiol Oil on Chronic Insomnia: The First Randomized, Double-Blind, Placebo-Controlled, Crossover, Pilot Study in Thailand

And a review of using CBD & PEA for sleep

Cannabinoids and Sleep: Exploring Biological Mechanisms and Therapeutic Potentials


In cancer patients, THC use is associated with an increase in survival time

The Use of Tetrahydrocannabinol Is Associated with an Increase in Survival Time in Palliative Cancer Patients: A Retrospective Multicenter Cohort Study

And in this survey of cancer survivors, 40% report using cannabis, most frequently for sleep, mood, stress, anxiety, depression, pain & recreation

Cannabis use after a cancer diagnosis in a population-based sample of cancer survivors

In public health data, cannabis users had lower rates of subjective cognitive decline

Association Between Cannabis Use and Subjective Cognitive Decline: Findings from the Behavioral Risk Factor Surveillance System (BRFSS)


For chronic pelvic pain, a survey of why people were using CBD or cannabis

Cannabidiol therapy prevalence for the treatment of chronic pelvic pain


For patients with chronic musculoskeletal pain, the most common reason for seeking medical cannabis certification was for spinal complaints

Understanding the Orthopedic Conditions for Which Patients Are Seeking Medical Cannabis Certification


Does cannabis use substitute for opioids? A preliminary exploratory survey in opioid maintenance patients


In dogs with osteoarthritis, CBD combined well with krill oil to reduce pain & inflammation after two weeks

Cannabidiol Plus Krill Oil Supplementation Improves Chronic Stifle Osteoarthritis in Dogs: A Double-Blind Randomized Controlled Trial


A welcome review of CBN: mechanisms of actions & benefits

Health benefits, pharmacological properties, and metabolism of cannabinol: A comprehensive review


A review of the psychiatric benefits of CBD (54 studies)

Cannabidiol and its Potential Evidence-Based Psychiatric Benefits - A Critical Review

And a review of 170 papers on CBD for neurological & neuropsychiatric disorders (nice chart of effects)

A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders

And a review of CBD's many beneficial effects

Beneficial effects of cannabidiol from Cannabis


For alcohol use disorder, a review of 16 brain scan studies on the potential of using CBD

Neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders: a systematic review

And in adult rats, using CBD to lower voluntary alcohol consumption after an adolescence of early drug initiation

Cannabidiol or ketamine for preventing the impact of adolescent early drug initiation on voluntary ethanol consumption in adulthood


For autism a review of treatment with cannabinoids

CANNABINOIDS AS A TREATMENT APPROACH FOR ASD: A LITERATURE REVIEW


For Dravet syndrome, a review of the efficacy & safety of CBD

The efficacy and safety of cannabidiol (CBD) in pediatric patients with Dravet Syndrome: a narrative review of clinical trials

And a cohort study from Spain that reports similar data

LOCAL EXPERIENCE ON THE USE OF CANNABIDIOL FOR THE TREATMENT OF REFRACTORY EPILEPSY: SAFETY AND EFFICACY ON A 10 PATIENT COHORT


A review of using products derived from cannabis for pain

Natural Products Derived from Cannabis sativa for Pain Management


In a mouse model of Alzheimer's disease, 30 days of high-dose CBD improved their learning, lessened memory deficits & lowered anxiety

Cannabidiol improves learning and memory deficits and alleviates anxiety in 12-month-old SAMP8 Mice


In a rat model of diabetes, cannabis oil improved their excessive thirst, excessive urination, loss of body mass, insulin levels & glucose levels in their bodily fluids as well as improvements & potential regeneration of the cells in their pancreas

Cannabis sativa L. Fixed Oil and Its Nanoemulsion: Effect on Diabetes and Dyslipidemia Induced in Rats

And in a mouse model of type 2 diabetes, the combination of CBD & S-allyl-cysteine (SAC) were effective as the treatment metformin for preserving neurovascular health, eye structures & cognitive function

S-allyl Cysteine and Cannabidiol are Equally Effective as Metformin in Preserving Neurovascular Integrity, Retinal Structure, and Cognitive Function in db/db Type 2 Diabetic Mice


In a rat model of pulmonary hypertension, CBD protected the heart as well as protected the liver by lowering the hypertension & possibly by direct anti-inflammatory effects on liver tissue via the NF-κB pathway

Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension in rats


In a rat model of facial nerve pain, CBD & its analog PECS-101 reduced hypersensitivity to pain via the TRPV1 receptor

Cannabidiol and it fluorinate analog PECS-101 reduces hyperalgesia and allodynia in trigeminal neuralgia via TRPV1 receptors


In mice exposed to the protein spike of COVID-19, the intranasal application of probiotics that produce PEA protected the lungs from injury via the lowering of inflammation & perhaps preventing the spread of infection

Intranasal delivery of PEA-producing Lactobacillus paracasei F19 alleviates SARS-CoV-2 spike protein-induced lung injury in mice


For the parasitic worm Echinococcus granulosus (hydatid worm or dog tapeworm), CBD combined well with the treatment albendazole to lower the weight of the cysts, detach their germinal layers & lower their viability by 80%

Anthelmintic Effect of Cannabidiol against Echinococcus granulosus sensu stricto

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