Best of cannabinoid science this week...
A beautiful set of visuals on the last 15 years of CBD research papers A bibliometrics and visualization analysis of cannabidiol research from 2004 to 2021 https://pubmed.ncbi.nlm.nih.gov/36408229/
In a survey of Polish caregivers for dementia patients, they thought CBD oil safer & more effective than conventional methods CBD Oil as a Miracle Drug: A Thematic Analysis of Caregivers’ Attitudes and Practices Towards Cannabidiol in Dementia Treatment https://journals.sagepub.com/doi/full/10.1177/00220426221145019
In Australian patients with arthritis, the use of CBD/THC & CBD-only products significantly reduced pain intensity Medicinal cannabis for Australian patients with chronic refractory pain including arthritis https://journals.sagepub.com/doi/full/10.1177/20494637221147115
In adults with insomnia, treatment with THC/CBD oil caused 60% of them to no longer qualify as insomniacs after two weeks with improvements including enhanced midnight melatonin levels, the time & quality of sleep & a higher daily functioning Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study https://pubmed.ncbi.nlm.nih.gov/36539991/
In patients with ulcers on their fingers from scleroderma (an autoimmune connective tissue & rheumatic disease that causes skin inflammation), topical CBD treatment caused lower pain scores, reduced painkiller use, higher health scores & an increase in total hours of sleep Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review https://pubmed.ncbi.nlm.nih.gov/36537770/
A review of how CBD may be helping neurodegenerative diseases via its effects on the gut microbiome The gut microbiota in neurodegenerative diseases: revisiting possible therapeutic targets for cannabidiol https://pubmed.ncbi.nlm.nih.gov/36544841/
Three clinical trials on how long a single oral dose of CBD stays in your blood How long does a single oral dose of cannabidiol persist in plasma? Findings from three clinical trials https://pubmed.ncbi.nlm.nih.gov/36478641/
A look at the relative contributions of the various liver enzymes that clear CBD from the body
Verifying in vitro-determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically-based pharmacokinetic modeling
In a rat model of PTSD, an ultra-low dose of THC reduced the fear response via the hippocampus (memory center) Effects of delta-9 tetrahydrocannabinol on fear memory labilization and reconsolidation: A putative role of GluN2B-NMDA receptor within the dorsal hippocampus https://pubmed.ncbi.nlm.nih.gov/36549374/
In the skin’s sebocytes (which produce the important oily sebum & regulate skin functions), the damage caused by blue light is lessened by CBD with actions including reduced inflammation, less reactive oxygen species & restoration of skewed cell cycles The Modulation of Blue-Light-Induced Inflammation, Intracellular Lipid Secretion, and Oxidative Stress in Sebocytes with Cannabidio https://pubmed.ncbi.nlm.nih.gov/36524438
In a model of ovarian hyperstimulation syndrome (an exaggerated response to excess hormones), CBD decreased the weight of the ovaries as well as down regulated genes that enhanced the syndrome (VEGF) Treatment of Ovarian Hyperstimulation Syndrome in a Mouse Model by Cannabidiol, an Angiogenesis Pathway Inhibitor https://pubmed.ncbi.nlm.nih.gov/36588534/
In lung cells, a mix of CBD, CBG & THCV worked synergistically with non-steroidal anti-inflammatory drugs like ibuprofen to reduce inflammation Phytocannabinoids Act Synergistically with Non-Steroidal Anti-Inflammatory Drugs Reducing Inflammation in 2D and 3D In Vitro Models https://pubmed.ncbi.nlm.nih.gov/36559009/
In lung immune cells, THC & CBD reduced the expression of pro inflammatory cytokines via the CB2 receptor Receptor-mediated effects of Δ9 -THC & CBD on the inflammatory response of alveolar macrophages https://pubmed.ncbi.nlm.nih.gov/36510483/
In mice, a combination of CBD & celecoxib (a Cox-2 inhibitor & non-steroidal anti-inflammatory drug) caused effective antidepressant & anti-anxiety effects via the microglia (guardian immune cells of the brain) A Novel Anti-Inflammatory Formulation Comprising Celecoxib and Cannabidiol Exerts Antidepressant and Anxiolytic Effects https://pubmed.ncbi.nlm.nih.gov/36520610/
In 34 young patients with drug resistant epilepsies, a high proportion of them found CBD to completely remove their seizures & all saw a significant reduction in frequency, duration & type of seizures A Pilot Study on the Use of Low Doses of CBD to Control Seizures in Rare and Severe Forms of Drug-Resistant Epilepsy https://pubmed.ncbi.nlm.nih.gov/36556430/
In a long term safety study of using CBD for epilepsy, it was found to be safe & it caused sustained seizure reductions for up to 192 weeks Long-term efficacy and safety of cannabidiol in patients with treatment-resistant epilepsies: 4-year results from the expanded access program https://pubmed.ncbi.nlm.nih.gov/36537757/
In epilepsy, CBD may help via its modulation of GABA (the brains primary inhibitory neurotransmitter) & in this study they found it combined well with two other epileptic medications (the neurosteroid ganaxolone & the benzodiazepine midazolam) that work via GABA as well Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy https://pubmed.ncbi.nlm.nih.gov/36493860/
In a human brain tissue model of epilepsy, CBD modulates neurotransmission via GABA (the brain’s most common inhibitory neurotransmitter) GABAergic Neurotransmission in Human Tissues Is Modulated by Cannabidiol https://pubmed.ncbi.nlm.nih.gov/36556407/