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Research Roundup: Aug 15, 2022



Best of cannabinoid science this week...


In humans with focal epilepsy, treatment with transdermal CBD lowered seizure levels Adjunctive Transdermal Cannabidiol for Adults With Focal Epilepsy: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/35802375


In 20 horses, 2 months of CBD caused no difference on sedation or ataxia (poor muscle control) Effects of a supplement containing Cannabidiol (CBD) on sedation and ataxia scores and health: Effects of Cannabidiol on Sedation and Ataxia https://pubmed.ncbi.nlm.nih.gov/35882292


A review of THC & CBD for pain & mental health conditions Tetrahydrocannabinol and cannabidiol medicines for chronic pain and mental health conditions https://pubmed.ncbi.nlm.nih.gov/35796920


In a computer analysis for diabetic effects, CBD, THC & full-spectrum extracts were found to inhibit α-glucosidase (an enzyme that breaks down glucose) α-Glucosidase inhibitory activity of cannabidiol, tetrahydrocannabinol and standardized cannabinoid extracts from Cannabis sativa https://pubmed.ncbi.nlm.nih.gov/35856057


In people getting bariatric surgery, cannabis had no negative effects on the subsequent weight loss Weight loss outcomes are not compromised in bariatric patients using cannabis https://pubmed.ncbi.nlm.nih.gov/35861881


In a survey, 90% of nurses thought patients should be able to use cannabis for their conditions & 67% believed that nurses should help the patients access it Nurse Leaders’ Attitudes Toward and Experiences With Medical Marijuana https://www.journalofnursingregulation.com/article/S2155-8256(22)00063-1/fulltext


A look at how dysregulation of the endocannabinoid system may underlie suicidal behavior & represent an avenue of treatment Characterizing chronic non-suicidal self-injury and other forms of repetitive and escalating suicide behaviour as endocannabinoid-mediated pain and reward disorders https://www.sciencedirect.com/science/article/abs/pii/S2468171722000059


In elite hockey players, a certain variant of FAAH is associated with super athletes, perhaps because it may cause higher pain tolerance & better stress coping FAAH rs324420 Polymorphism Is Associated with Performance in Elite Rink-Hockey Players https://www.mdpi.com/2079-7737/11/7/1076


A cool review looks at how cannabinoid signaling helps regulate our skeletal muscle Molecular networks underlying cannabinoid signaling in skeletal muscle plasticity https://pubmed.ncbi.nlm.nih.gov/35862111


An analysis of the metabolites of hemp seeds finds that they have antioxidative effects Metabolomics Analysis Revealed the Characteristic Metabolites of Hemp Seeds Varieties and Metabolites Responsible for Antioxidant Properties https://pubmed.ncbi.nlm.nih.gov/35800608