Best of the Week...
Zynerba presents their new Phase 2 data on their transdermal CBD gel for treating autism
Longer Term Tolerability and Efficacy of ZYN002 Cannabidiol Transdermal Gel in Children and Adolescents with Autism Spectrum Disorder (ASD): An Open-Label Phase 2 Study
https://zynerba.com/wp-content/uploads/2021/09/SSBP_BRIGHT_08.18.21_FINAL.pdf
This review takes a deep dive into the data on CBD for Alzheimer’s disease
Understanding the Modulatory Effects of Cannabidiol on Alzheimer’s Disease
https://www.mdpi.com/2076-3425/11/9/1211
A review of the effects of cannabis & the cannabinoids like CBD on athletic performance
Cannabis and Athletic Performance
https://link.springer.com/article/10.1007/s40279-021-01505-x
In humans, younger people have more CB1 receptors in their muscle than older people – but you can increase your cannabinoid receptor levels with resistance exercise
Cannabinoid receptor 1 expression is higher in muscle of old vs. young males, and increases upon resistance exercise in older adults
https://www.nature.com/articles/s41598-021-97859-3
A review of the use of cannabinoids for skin health
Topical Use of Cannabis sativa L. Biochemicals
https://www.mdpi.com/2079-9284/8/3/85
American Family Physician reviews the positive evidence on melatonin for sleep
Melatonin to Treat Insomnia in Older Adults
https://www.aafp.org/afp/2021/0900/p297.html
Dr. Piomelli reviews the promise of endocannabinoid-based therapies
Endocannabinoid-Based Therapies
https://www.annualreviews.org/doi/abs/10.1146/annurev-pharmtox-052220-021800
Also, you watch our interview with Dr. Piomelli here.
Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)
A review of the use of cannabinoids in dentistry with a special focus on CBD
The Current and Potential Application of Medicinal Cannabis Products in Dentistry
https://www.mdpi.com/2304-6767/9/9/106
A case report of a man with ALS & severe itching who used oral cannabinoids to treat his skin condition
Cannabinoids for the treatment of refractory neuropathic pruritus in amyotrophic lateral sclerosis: A case report
https://pubmed.ncbi.nlm.nih.gov/34510973/
In humans with COVID-19, a certain genetic variant of the CB2 receptor leads to worse outcomes
Functional variation (Q63R) in the cannabinoid CB2 receptor may affect the severity of COVID-19: a human study and molecular docking
https://pubmed.ncbi.nlm.nih.gov/34514519/
A review of the other receptors that may one day be known as endocannabinoid receptors (hattip to Stuart Tomc)
Endocannabinoid signaling pathways: beyond CB1R and CB2R
https://pubmed.ncbi.nlm.nih.gov/33978927/
A review of using the cannabinoids to treat the pain of MS
Efficacy, tolerability and safety of cannabinoids for management of pain in adult patients with multiple sclerosis: A systematic review and meta-analysis
Preclinical Research & Cannabinoid Chemistry
The CB2 receptor is a key pathway to control homeostasis of our brain’s microglia (immune cells that respond to potential threats) Cannabinoid receptor 2 is necessary to induce toll-like receptor-mediated microglial activation https://pubmed.ncbi.nlm.nih.gov/34499767/ In a mouse model of inflammatory pain, treatment with JNK (a novel pain inhibitor) works via the CB2 receptor in females & by both the CB1 & CB2 receptor in males Sex and dose-dependent antinociceptive effects of the JNK (c-Jun N-terminal kinase) inhibitor SU 3327 are mediated by CB2 receptors in female, and CB1/CB2 receptors in male mice in an inflammatory pain model https://www.sciencedirect.com/science/article/abs/pii/S0361923021002677 In mice with no CB1 receptors in their liver cells, they saw no difference in their response to a high fat diet & concluded that the CB1 receptors had no direct role in the development of nonalcoholic fatty liver disease or liver fibrosis Cannabinoid receptor-1 signaling in hepatocytes and stellate cells does not contribute to NAFLD https://pubmed.ncbi.nlm.nih.gov/34499619/ In a fruit fly model of depression, an extract made from hemp seeds alleviated depression symptoms & modulated the circadian rhythm (hattip to Stuart Tomc, who somehow found this 3 months before it’s publication date)
Anti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model https://pubmed.ncbi.nlm.nih.gov/34362287/