Search

Research Roundup: Sept 20, 2021



Best of the Week...


Zynerba presents their new Phase 2 data on their transdermal CBD gel for treating autism

Longer Term Tolerability and Efficacy of ZYN002 Cannabidiol Transdermal Gel in Children and Adolescents with Autism Spectrum Disorder (ASD): An Open-Label Phase 2 Study

https://zynerba.com/wp-content/uploads/2021/09/SSBP_BRIGHT_08.18.21_FINAL.pdf

This review takes a deep dive into the data on CBD for Alzheimer’s disease

Understanding the Modulatory Effects of Cannabidiol on Alzheimer’s Disease

https://www.mdpi.com/2076-3425/11/9/1211

A review of the effects of cannabis & the cannabinoids like CBD on athletic performance

Cannabis and Athletic Performance

https://link.springer.com/article/10.1007/s40279-021-01505-x

In humans, younger people have more CB1 receptors in their muscle than older people – but you can increase your cannabinoid receptor levels with resistance exercise

Cannabinoid receptor 1 expression is higher in muscle of old vs. young males, and increases upon resistance exercise in older adults

https://www.nature.com/articles/s41598-021-97859-3

A review of the use of cannabinoids for skin health

Topical Use of Cannabis sativa L. Biochemicals

https://www.mdpi.com/2079-9284/8/3/85

American Family Physician reviews the positive evidence on melatonin for sleep

Melatonin to Treat Insomnia in Older Adults

https://www.aafp.org/afp/2021/0900/p297.html

Dr. Piomelli reviews the promise of endocannabinoid-based therapies

Endocannabinoid-Based Therapies

https://www.annualreviews.org/doi/abs/10.1146/annurev-pharmtox-052220-021800

Also, you watch our interview with Dr. Piomelli here.


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

A review of the use of cannabinoids in dentistry with a special focus on CBD

The Current and Potential Application of Medicinal Cannabis Products in Dentistry

https://www.mdpi.com/2304-6767/9/9/106

A case report of a man with ALS & severe itching who used oral cannabinoids to treat his skin condition

Cannabinoids for the treatment of refractory neuropathic pruritus in amyotrophic lateral sclerosis: A case report

https://pubmed.ncbi.nlm.nih.gov/34510973/

In humans with COVID-19, a certain genetic variant of the CB2 receptor leads to worse outcomes

Functional variation (Q63R) in the cannabinoid CB2 receptor may affect the severity of COVID-19: a human study and molecular docking

https://pubmed.ncbi.nlm.nih.gov/34514519/

A review of the other receptors that may one day be known as endocannabinoid receptors (hattip to Stuart Tomc)

Endocannabinoid signaling pathways: beyond CB1R and CB2R

https://pubmed.ncbi.nlm.nih.gov/33978927/

A review of using the cannabinoids to treat the pain of MS

Efficacy, tolerability and safety of cannabinoids for management of pain in adult patients with multiple sclerosis: A systematic review and meta-analysis

https://oss.signavitae.com/mre-signavitae/article/20210915-557/pdf/21st%20Panhellenic%20Congress%20on%20Ragement%20and%20Palliative%20Care%2010.pdf



Preclinical Research & Cannabinoid Chemistry

The CB2 receptor is a key pathway to control homeostasis of our brain’s microglia (immune cells that respond to potential threats) Cannabinoid receptor 2 is necessary to induce toll-like receptor-mediated microglial activation https://pubmed.ncbi.nlm.nih.gov/34499767/ In a mouse model of inflammatory pain, treatment with JNK (a novel pain inhibitor) works via the CB2 receptor in females & by both the CB1 & CB2 receptor in males Sex and dose-dependent antinociceptive effects of the JNK (c-Jun N-terminal kinase) inhibitor SU 3327 are mediated by CB2 receptors in female, and CB1/CB2 receptors in male mice in an inflammatory pain model https://www.sciencedirect.com/science/article/abs/pii/S0361923021002677 In mice with no CB1 receptors in their liver cells, they saw no difference in their response to a high fat diet & concluded that the CB1 receptors had no direct role in the development of nonalcoholic fatty liver disease or liver fibrosis Cannabinoid receptor-1 signaling in hepatocytes and stellate cells does not contribute to NAFLD https://pubmed.ncbi.nlm.nih.gov/34499619/ In a fruit fly model of depression, an extract made from hemp seeds alleviated depression symptoms & modulated the circadian rhythm (hattip to Stuart Tomc, who somehow found this 3 months before it’s publication date)

Anti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model https://pubmed.ncbi.nlm.nih.gov/34362287/