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Research Roundup: Apr 3, 2024

Best of cannabinoid science this week...

In people with menstrual-related symptoms, CBD reduced symptoms, irritability, anxiety, stress & subjective severity scores

Examination of the Effects of Cannabidiol on Menstrual-Related Symptoms

In patients with temporomandibular disorders (pain issues of the face region), CBD reduced pain, muscle tension & bruxism (teeth grinding during sleep)

Cannabidiol Intervention for Muscular Tension, Pain, and Sleep Bruxism Intensity—A Randomized, Double-Blind Clinical Trial

In a survey of 1300+ people from a tertiary headache center, they reported using cannabis to treat their headaches & sleep concerns with the majority reporting improvements in migraine intensity, duration & frequency as well as nausea, sleep disturbances, anxiety & depression

Characterizing Cannabis Use and Perceived Benefit in a Tertiary Headache Center Patient Sample

In a survey of 267 CBD users, the top five reasons for using CBD were stress, sleep problems, improvement in well-being, improved mood & anxiety relief

Cannabidiol usage, efficacy, and side effects: analyzing the impact of health conditions, medications, and cannabis use in a cross-sectional online pilot study

In people with tuberous sclerosis complex (the growth of many non-cancerous tumors that often lead to seizures), a healthcare cost analysis found a benefit in adding CBD to usual standard of care treatment

A Cost-Utility Analysis of Add-On Cannabidiol Versus Usual Care Alone for the Treatment of Seizures Associated with Tuberous Sclerosis Complex in England and Wales

A long review of PEA for chronic neuropathic pain (great charts!)

A Decades-Long Journey of Palmitoylethanolamide (PEA), as a Cornerstone in Chronic Neuropathic Pain Management: A Comprehensive Narrative Review

A case report of using CBG for the anxiety of the COVID pandemic

Minor Cannabinoids for the Treatment of Anxiety During the COVID-19 Pandemic: A Case Report

For Alzheimer's disease, a positive review of 37 studies on the use of cannabinoids


And a molecular assessment of why cannabinoids make sense for treating Alzheimer's

Exploring Cannabis sativa L for Anti-Alzheimer Potential: An extensive Computational Study including Molecular Docking, Molecular Dynamics, and ADMET Assessments

A review on using cannabis oil for cancer related pain

Cannabinoids for Cancer-related Pain Management: An Update on Therapeutic Applications and Future Perspectives

And a review of cannabis for pain management

Cannabis in pain management

A big review of recent clinical THC trials

Δ9-Tetrahydrocannabinol (THC): A Critical Overview of Recent Clinical Trials and Suggested Guidelines for Future Research

A review of how exercise works with the endocannabinoids & our dopamine reward system (nice ECS & exercise charts)

Aerobic Exercise and Endocannabinoids: A Narrative Review of Stress Regulation and Brain Reward Systems

For exercise, cannabis users seem more sensitive to the positive effects

Prior acute exercise restores postprandial fat oxidation in active cannabis users

In rats with neuroinflammation, CBD improved their memory & decreased inflammatory cytokines

Cannabidiol improves memory and decreases IL-1β serum levels in rats with lipopolysaccharide-induced inflammation

In a rat model of traumatic brain injury, CBD caused neuroprotection & restored their synaptic remodeling via TNF-α in the astrocytes (a prominent brain immune cell)

Purinergic Astrocyte Signaling Driven by TNF-α After Cannabidiol Administration Restores Normal Synaptic Remodeling Following Traumatic Brain Injury

In a tissue & rat model of an inflamed prostate & chronic pelvic pain syndrome, CBD lowered pain & inflammation via CB2 & TRPV1 receptors as well as the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) pathway

Cannabidiol Alleviates Chronic Prostatitis and Chronic Pelvic Pain Syndrome via CB2 Receptor Activation and TRPV1 Desensitization

In a mouse model of epilepsy, CBD caused anticonvulsant effects alone but when combined with low levels of THC, they worked better than either cannabinoids alone, probably via a serotonin receptor

Cannabidiol Exerts Anticonvulsant Effects Alone and in Combination with Δ9-THC through the 5-HT1A Receptor in the Neocortex of Mice

In a mouse model of the toxicity from high doses of nicotine, CBD reduced anxiety behaviors via liver enzymes, protection of tissues, balancing of redox reactions & mitigating changes to the levels of BDNF (an important brain growth factor)

Cannabidiol Modulation of Nicotine-Induced Toxicity: Assessing Effects on Behavior, Brain-Derived Neu-Rotrophic Factor, and Oxidative Stress C57BL/6 Mice

In goldfish exposed to an insecticide, CBD protected the brain from oxidative stress

Antioxidant effects of the phytocannabinoid cannabidiol (CBD) in the brain of chlorpyrifos-exposed goldfish (Carassius auratus)

In a rat model of type 2 diabetes, the terpene beta-caryophyllene lowered oxidative stress as well as dysfunction of the liver cell’s mitochondria (powerhouse of the cell)

β-caryophyllene attenuates oxidative stress and hepatocellular mitochondrial dysfunction in type-2 diabetic rats induced with high fat and fructose diets

In a rat model of high blood pressure in the lungs, the terpene beta-caryophyllene lowered hypertension & reduced oxidative stress

Effect of free and nanoemulsified β-caryophyllene on monocrotaline-induced pulmonary arterial hypertension

The antimicrobial activity of two cannabis extracts

Chemical Characterization and Evaluation of the Antimicrobial Activity of Extracts from Two Cultivars of Cannabis sativa L. (Tisza and Kompolti) Grown in Sardinia

In spinal cord slices, anandamide lowered spinal pain transmission under both control & inflammatory conditions

Dual effect of anandamide on spinal nociceptive transmission in control and inflammatory conditions

On using marine bacteria to produce cannabinoids

Discovery of Latent Cannabichromene Cyclase Activity in Marine Bacterial Flavoenzymes


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