Best of the Week...
In lung cells exposed to the spike protein of SARS-CoV-2, ultramicronized PEA reduced all inflammatory markers
Ultramicronized Palmitoylethanolamide Inhibits NLRP3 Inflammasome Expression and Pro-Inflammatory Response Activated by SARS-CoV-2 Spike Protein in Cultured Murine Alveolar Macrophages
This review gives a physician’s perspective on the cannabinoids for pain with an emphasis on CBD
The Role of Cannabis, Cannabidiol and Other Cannabinoids in Chronic Pain. The Perspective of Physicians
In mice, treatment with topical CBD led their skin to produce more aquaporin-3 (important in skin water retention) & to be more moisturized
Cannabidiol Application Increases Cutaneous Aquaporin-3 and Exerts a Skin Moisturizing Effect
In healthy young humans, this randomized clinical trial showed that CBD enhanced their verbal episodic memory
Cannabidiol enhances verbal episodic memory in healthy young participants: A randomized clinical trial
This review looks at using PEA to treat cognitive dysfunction syndrome in pets (a model of Alzheimer’s)
Successful and Unsuccessful Brain Aging in Pets: Pathophysiological Mechanisms behind Clinical Signs and Potential Benefits from Palmitoylethanolamide Nutritional Intervention
A pharmacist’s take on CBD & drug-drug interactions (a helpful one to bookmark)
The Safety and Efficacy of CBD—A Pharmacist’s Perspective
Our medical adviser Dr. Jamie Corroon publishes on the lack of data behind the idea of using CBN for sleep
Cannabinol and Sleep: Separating Fact from Fiction
This review looks at targeting the ECS for social anxiety disorder – with a focus on CBD
The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics
Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)
In the blood of dogs, they measured the effects of CBD & found it to be anti-inflammatory & immuno-modulating
Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood
A review of the effects of the cannabino
nabis and cannabinoids on the endocrine system
In a study of the genetics of those with treatment resistant-epilepsy taking CBD, they found genetic pathways related to cholesterol metabolism & glutathione conjugation
Pharmacogenetic predictors of cannabidiol (CBD) response and tolerability in treatment-resistant epilepsy
A review of using CBD to treat rare epilepsies
Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain
In children with rare epilepsies, a CBD gel was safe, well-tolerated & lessened seizures & disease burden
Safety and Tolerability of Transdermal Cannabidiol Gel in Children With Developmental and Epileptic Encephalopathies: A Nonrandomized Controlled Trial
In humans with arthritis, 30 mg of synthetic CBD not helpful for the pain
Cannabidiol treatment in hand osteoarthritis and psoriatic arthritis: a randomized, double-blind placebo-controlled trial
A review of how the cannabinoids relate to our fear & anxiety systems
Cannabinoids: revealing their complexity and role in central networks of fear and anxiety
This review looks at how the endocannabinoid system forms a bridge between Alzheimer’s disease & the gut microbiome
The Endocannabinoid System: A Bridge between Alzheimer’s Disease and Gut Microbiota
This review looks at how lowering the activation of endocannabinoid signaling in the brain’s microglia (immune cells) lessens the neuroinflammation of Alzheimer’s disease
Potentiation of microglial endocannabinoid signaling alleviates neuroinflammation in Alzheimer's disease
A review of targeting the CB2 receptor for Alzheimer’s disease
Cannabinoid receptor 2 selective agonists and Alzheimer's disease: An insight into the therapeutic potentials
Preclinical Research & Cannabinoid Chemistry
In cells, CBD binds to a sodium channel (relevant to epilepsy)
Cannabidiol Selectively Binds to the Voltage-Gated Sodium Channel Nav1.4 in Its Slow-Inactivated State and Inhibits Sodium Current
A study of how CBD & other cannabinoids alter the liver enzyme CYP2D6 - a possible role in CBD’s regulation of anandamide levels
Differential Interactions of Selected Phytocannabinoids with Human CYP2D6 Polymorphisms
In bladder cancer cells, CBD promoted cell death
Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment
In male rats, CBD treatment when they are teenagers leads to later changes in metabolism
Juvenile cannabidiol chronic treatments produce robust changes in metabolic markers in adult male Wistar rats
In female rats exposed to the smell of a predator, they had lower levels of 2-AG & higher levels of AEA in the amygdala (fear center of the brain) versus male rats who showed none of these alterations
Amygdalar endocannabinoids are affected by predator odor stress in a sex-specific manner and modulate acoustic startle reactivity in female rats
In male rats allowed to copulate until satiety, activation of the CB1 receptors & the release of endocannabinoids modulated dopamine & glutamate levels, possibly leading to “the long-lasting physiological changes that characterize sexually satiated rats”
Endocannabinoids Released in the Ventral Tegmental Area During Copulation to Satiety Modulate Changes in Glutamate Receptors Associated With Synaptic Plasticity Processes
In rats given ZnO nanoparticles (a treatment for cancer & diabetes), it modified the response of their hearts to the cannabinoid receptors
ZnO Nanoparticles Induce Dyslipidemia and Atherosclerotic Lesions Leading to Changes in Vascular Contractility and Cannabinoid Receptors Expression as Well as Increased Blood Pressure
In mice with no Alpha/Beta-Hydrolase Domain 6 (ABHD6 – an enzyme that degrades 2-AG), they had to urinate more frequently & were more sensitive to mechanical pain
Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6 Knockout Rat