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Research Roundup: Sep 5, 2023



Best of cannabinoid science this week...


In autistic patients using full spectrum cannabis extracts for six months, detailed surveys found improvements in most core & comorbid symptoms as well as increased quality of life with mild & and frequent side effects Individually tailored dosage regimen of full-spectrum Cannabis extracts for autistic core and comorbid symptoms: a real-life report of multi-symptomatic benefits https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1210155/full


A survey of sports medicine orthopedic surgeons found that a majority believe CBD has a role in post operative pain management & for managing acute pain & inflammation after an injury Perceptions & Opinions on Cannabidiol Among Sports Medicine Orthopaedic Surgeons https://journals.sagepub.com/doi/abs/10.1177/2325967123S00336


In cancer patients with taste alterations from chemotherapy, 8 days of 300 milligrams of CBD helped to improve their ability to differentiate between various taste strengths Prevention of Taste Alterations in Patients with Cancer Receiving Paclitaxel- or Oxaliplatin-Based Chemotherapy-A Pilot Trial of Cannabidiol https://pubmed.ncbi.nlm.nih.gov/37447339/


In people with drug-resistant frontal lobe epilepsy, CBD improved their seizures & quality of life The effect of cannabidiol on seizure features and quality of life in drug-resistant frontal lobe epilepsy patients: a triple-blind controlled trial https://pubmed.ncbi.nlm.nih.gov/37470002/ And in people with epilepsy from Rett syndrome, CBD reduced their number of seizures as well as improving spasticity, agitation & anxiety attacks Efficacy and tolerance of cannabidiol in the treatment of epilepsy in patients with Rett syndrome https://pubmed.ncbi.nlm.nih.gov/37485779/


In people with dystonia (involuntary muscle contractions), medical cannabis use caused significant subjective improvements in symptoms, pain & quality of life

A single-center real-life study on the use of medical cannabis in patients with dystonia


In brain scans of people at risk for psychosis, the lower levels of glutamate in their hippocampus were partially normalized by treatment with 600 milligrams of CBD Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk https://www.medrxiv.org/content/10.1101/2023.03.02.23286709v1


In post-menopausal women with knee osteoarthritis, on how Tai Chi alters their endocannabinoids & oxylipins & what this means for their pain Tai Chi exercise reduces circulating levels of inflammatory oxylipins in postmenopausal women with knee osteoarthritis: results from a pilot study https://pubmed.ncbi.nlm.nih.gov/37654656/


In horses, an analysis of how CBD moves through their body Pharmacokinetic modelling of orally administered cannabidiol and implications for medication control in horses https://pubmed.ncbi.nlm.nih.gov/37621871/


A review of using CBD for treating skin diseases Cannabidiol as a Novel Therapeutic for Skin Treatments https://www.cientperiodique.com/article/CPQME-15-1-438.pdf And a review of the application of cannabinoids to skin diseases The Skin and Natural Cannabinoids-Topical and Transdermal Applications https://pubmed.ncbi.nlm.nih.gov/37513960/


For migraines, a review of using the cannabinoids The Exploration of Cannabis and Cannabinoid Therapies for Migraine https://pubmed.ncbi.nlm.nih.gov/37515745/ And a review of 64 studies on using them for chronic headaches Chronic headache and cannabinoids use: myths and truths https://www.scielo.br/j/brjp/a/h9zH8fRP6JM33JVJnkwhdCd/?lang=en


A review of using cannabinoids for pain management Neuropharmacology of endogenous, synthetic and phytocannabinoids for pain management https://pubmed.ncbi.nlm.nih.gov/37283484/


A review of how cannabinoids regulate anxiety, fear & trauma Cannabinoid Regulation of Fear and Anxiety: an Update https://pubmed.ncbi.nlm.nih.gov/31030284/


A review of CBD for Alzheimer's disease

CANNABIDIOL AS A NOVEL THERAPY FOR ALZHEIMER’S DISEASE


A glorious review of how the CB1 receptors manage the brain energy processes (with great charts) Type-1 cannabinoid receptors and their ever-expanding roles in brain energy processes https://pubmed.ncbi.nlm.nih.gov/37515372/

Another toxicity report on hemp extracts found no genetic toxicity & nothing considered toxicologically relevant An evaluation of the genotoxicity and 90-day repeated-dose toxicity of a CBD-rich hemp oil https://pubmed.ncbi.nlm.nih.gov/37501578/


In a mouse model of diabetes, CBD lowered the inflammatory response via the control of genetic transcription Cannabidiol ameliorates inflammatory response partly by AGE-RAGE pathway in diabetic mice https://pubmed.ncbi.nlm.nih.gov/37486107/ And in a rat model of diabetes, cannabis seeds caused significant improvements to all metabolic factors measured Biochemical Changes Induced by the Administration of Cannabis sativa Seeds in Diabetic Wistar Rats https://pubmed.ncbi.nlm.nih.gov/37447270/


In a mouse model of diabetes causing heart problems, the terpene beta caryophyllene inhibited oxidative stress & inflammation with “remarkable protective effects” via the CB2 receptors & the TLR4/NF-κB/MAPK pathway β-Caryophyllene, a Dietary Phytocannabinoid, Alleviates Diabetic Cardiomyopathy in Mice by Inhibiting Oxidative Stress and Inflammation Activating Cannabinoid Type-2 Receptors https://pubmed.ncbi.nlm.nih.gov/37588762/


In a tissue model of Parkinson's disease, CBN caused changes to gene expression that helped to protect the mitochondria (powerhouse of the cell) Transcriptome Highlights Cannabinol Modulation of Mitophagy in a Parkinson's Disease In Vitro Model https://pubmed.ncbi.nlm.nih.gov/37627228/


Under resting conditions, the endocannabinoid restricts the stress response via lowering activation of the HPA axis through the control of hormone releasing neurons in the hypothalamus Disruption of tonic endocannabinoid signalling triggers cellular, behavioural and neuroendocrine responses consistent with a stress response https://pubmed.ncbi.nlm.nih.gov/37482931/

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