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Research Roundup: Sep 26, 2023



Best of cannabinoid science this week...


A recommendation guideline for CBD recommends a potential “Acceptable Daily Intake (ADI) value of 0.43 mg/kg-bw/d (e.g., 30 mg/d for 70-kg adult)”, but for those with healthy livers, 160mg/day

Cannabidiol safety considerations: Development of a potential acceptable daily intake value and recommended upper intake limits for dietary supplement use


In daily cannabis users, 10 weeks of CBD (200 mg per day) helped to restore the functional connectivity differences seen in their hippocampus (memory center of the brain), precentral gyrus (motor cortex), lingual gyrus (vision processing center) & amygdala (emotional processing center) Daily Cannabidiol Administration for 10 Weeks Modulates Hippocampal and Amygdalar Resting-State Functional Connectivity in Cannabis Users: A Functional Magnetic Resonance Imaging Open-Label Clinical Trial https://pubmed.ncbi.nlm.nih.gov/37603080/


In adults with blepharospasm (uncontrolled blinking & eyelid twitching), CBD combined well with the type of treatment of botulinum toxin to improve several different measures Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm - A Randomized Pilot Study https://pubmed.ncbi.nlm.nih.gov/37606606/


Among middle-aged adults using medical cannabis, the frequent & non frequent users had no differences in cognitive outcomes but those with problematic cannabis use scored significantly worse on one cognitive domain Longitudinal Associations Between Cannabis Use and Cognitive Impairment in a Clinical Sample of Middle-Aged Adults Using Cannabis for Medical Symptoms https://pubmed.ncbi.nlm.nih.gov/37625034/


A survey of 100 people using medical cannabis found the majority were using it for their neurological disorders & reported a decrease in symptoms as well as an increase in energy, vitality, ability to perform their professional duties, appetite & leap Quality of Life in Patients Receiving Medical Cannabis https://pubmed.ncbi.nlm.nih.gov/37581814/


Public health data shows that cannabis users are less likely to get kidney stones Association between marijuana use and kidney stone: a cross-sectional study of NHANES 2009 to 2018 https://www.frontiersin.org/articles/10.3389/fphar.2023.1214647/full


On the entourage effect, a solid review of what we know & what we don't know Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn't https://pubmed.ncbi.nlm.nih.gov/37626819/


A big review on using cannabinoids for neurological disorders Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies https://journals.lww.com/nrronline/fulltext/2024/04000/cannabinoids_and_endocannabinoids_as_therapeutics.22.aspx


For children with cancer, a meta-analysis of 19 studies on using cannabinoids for their symptoms Cannabinoids for symptom management in children with cancer: A systematic review and meta-analysis https://pubmed.ncbi.nlm.nih.gov/37635461/


A review of cannabis use in intensive care (22 articles) Cannabis use in the intensive care setting: A scoping review https://pubmed.ncbi.nlm.nih.gov/37544047/


A review of the many cannabinoids for pain management Neuropharmacology of endogenous, synthetic and phytocannabinoids for pain management https://www.magiran.com/paper/2592686/neuropharmacology-of-endogenous-synthetic-and-phytocannabinoids-for-pain-management


A review of using cannabis compounds against parasites Cannabis sativa- A Source of Antiparasitic Compounds? https://ideas.repec.org/a/abf/journl/v50y2023i3p41701-41707.html


In skin stem cells exposed to UV radiation, CBD & CBG protected them from damage Cannabidiol and Cannabigerol Modify the Composition and Physicochemical Properties of Keratinocyte Membranes Exposed to UVA https://pubmed.ncbi.nlm.nih.gov/37569799/


In an animal model of spinal fusion surgery, CBD & THC upregulated bone growth factors & may enhance bone healing (a poster from the North American Spine Society Conference) Gene expression changes with short- and long-term cannabinoid treatments in a spinal fusion model https://www.sciencedirect.com/science/article/abs/pii/S1529943023029765


In a rat model of neuropathic pain, the CB1 receptors of the stem cells contributed significantly to their pain relieving & tissue repairing capabilities by stimulating growth factor secretion & suppressing proinflammatory cytokine release The role of cannabinoid CB1 receptors in the antinociceptive and reparative actions of mesenchymal stem cells in rats with peripheral neuropathic pain https://onlinelibrary.wiley.com/doi/pdf/10.1002/ibra.12129

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