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Research Roundup: Sep 26, 2022



Best of cannabinoid science this week...


In a small open-label study of people with opioid use disorder already using buprenorphine, 600 mg of CBD for 3 days significantly lowered cue-induced craving Cannabidiol Effect on Cue-Induced Craving for Individuals with Opioid Use Disorder Treated with Buprenorphine: A Small Proof-of-Concept Open-Label Study https://pubmed.ncbi.nlm.nih.gov/36105269

Wound-healing with a CBD hydrogel: antioxidant effects, reduced inflammatory response, facilitated wound healing & increased blood vessel formation A cannabidiol-containing alginate based hydrogel as novel multifunctional wound dressing for promoting wound healing https://pubmed.ncbi.nlm.nih.gov/35523648

In patients with MS, nabiximols (1:1 THC:CBD spray) reduced spasticity as well as a range of spasticity-associated symptoms

A real-world evidence study of nabiximols in multiple sclerosis patients with resistant spasticity: Analysis in relation to the newly described 'spasticity-plus syndrome'

https://pubmed.ncbi.nlm.nih.gov/35590453


In mice being fed high-carb ultra-processed food, CBD lowered the anxiety-inducing nature & compulsive behaviors caused by that diet Cannabidiol ameliorates the anxiogenic and compulsive-like behaviors induced by chronic consumption of a high-carbohydrate diet in male mice https://pubmed.ncbi.nlm.nih.gov/36040711


In a rat model of Parkinson’s disease, injection of CBD into the brain improved their fine motor skills via the GPR55 receptor & GABA Intrapallidal injection of cannabidiol or a selective GPR55 antagonist decreases motor asymmetry and improves fine motor skills in hemiparkinsonian rats https://pubmed.ncbi.nlm.nih.gov/36120297


In female rats, CBD helped to block them from storing fearful memories via the CB1 receptor Cannabidiol impairs fear memory reconsolidation in female rats through dorsal hippocampus CB1 but not CB2 receptor interaction https://pubmed.ncbi.nlm.nih.gov/36049316


In a mouse model of chemotherapy, CBD lowered neuropathic pain & inflammatory cytokines via the CB2 & Toll-like receptors (TLR4) in the spinal cord’s microglia (immune cells) Cannabidiol Prevents Chemotherapy-Induced Neuropathic Pain by Modulating Spinal TLR4 Via Endocannabinoid System Activation https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4199529


In a rat model of meth addiction, CBD seems to help lower the potential to relapse via a dopamine receptor

Intra-Accumbal D1- But not D2-Like Dopamine Receptor Antagonism Reverses the Inhibitory Effects of Cannabidiol on Extinction and Reinstatement of Methamphetamine Seeking Behavior in Rats

https://pubmed.ncbi.nlm.nih.gov/36048545


A review of insomnia & CBD suggests a little bit helps to quicken sleep & a lot can keep it away

Cannabidiol (CBD) and Insomnia : Literature review

https://www.cambridge.org/core/journals/european-psychiatry/article/cannabidiol-cbd-and-insomnia-literature-review/14E2AE95EF840BCAA0074D244E81B457