Best of cannabinoid science this week...
In an observational study, people taking CBD for long periods of time had significant decreases in daytime drowsiness & in older men, higher testosterone levels The Effects of Long-Term Self-Dosing of Cannabidiol on Drowsiness, Testosterone Levels, and Liver Function https://pubmed.ncbi.nlm.nih.gov/36968131/ And in a clinical study of people with worry & anxiety, an acute dose of 300 milligrams of CBD did not lower their symptoms but taking it for two weeks reduce their anxiety The effects of cannabidiol on worry and anxiety among high trait worriers: a double-blind, randomized placebo controlled trial https://pubmed.ncbi.nlm.nih.gov/37552290/
In 99 patients with chronic neuropathic pain, medical cannabis caused significant decreases of severe pain & sleep disturbances with no severe adverse events Medical Cannabis Alleviates Chronic Neuropathic Pain Effectively and Sustainably without Severe Adverse Effect: A Retrospective Study on 99 Cases https://karger.com/mca/article/6/1/89/860557
In patients with gynecological cancer, 1:1 THC:CBD oil reduced the nausea effects of chemotherapy Oral Tetrahydrocannabinol (THC):Cannabinoid (CBD) Cannabis Extract Adjuvant for Reducing Chemotherapy-Induced Nausea and Vomiting (CINV): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial https://pubmed.ncbi.nlm.nih.gov/37608911/
A survey finds parents giving unlicensed CBD products to their kids with ADHD, autism & especially generalized anxiety disorder Parental Perceptions and Usage of Unlicensed Cannabidiol Products in Children With Anxiety and Neurodevelopmental Disorders https://meridian.allenpress.com/jppt/article/28/4/323/494868
A review of how CBD may be causing its painkilling effect Can cannabidiol have an analgesic effect? https://pubmed.ncbi.nlm.nih.gov/37584368/ And a book chapter on the painkilling effects of cannabis The Analgesic Effects of Cannabis https://link.springer.com/chapter/10.1007/978-3-031-35155-6_7
A review of cannabis for endometriosis Overview of Medicinal Cannabis as a treatment for Endometriosis associated symptoms https://c2852a77-6c61-4e7b-8813-b350941ce4c2.usrfiles.com/ugd/c2852a_a16e652aac064fbab5169ce0504ee0d9.pdf
For fibromyalgia, a review of medicinal cannabis Medicinal Cannabis for Patients with Fibromyalgia: A Review https://ideas.repec.org/a/adm/journl/v12y2023i8p1-4.html
For glaucoma, a review of the therapeutic potential of the cannabinoids Therapeutic Potential of Cannabinoids in Glaucoma https://pubmed.ncbi.nlm.nih.gov/37631064/
In a mouse model of bone fracture, CBD & CBG reduced pain comparable to NSAIDs & promoted bone healing via multiple mechanisms Cannabidiol and cannabigerol, non-psychotropic cannabinoids, as analgesics that effectively manage bone fracture pain and promote healing in mice https://pubmed.ncbi.nlm.nih.gov/37597163/
In mice, CBD lowered nicotine self-administration Cannabidiol Attenuates Nicotine Self-Administration in Mice https://escholarship.org/uc/item/8g4825wx
In mice with liver injuries from an organic pollutant, 30 days of CBD protected the liver Cannabidiol alleviates perfluorooctane sulfonate-induced macrophage extracellular trap mediate inflammation and fibrosis in mice liver https://pubmed.ncbi.nlm.nih.gov/37591127/
In a mouse model of heart damage from diabetes, the terpene beta caryophyllene cause remarkable protective effects by lowering oxidative stress & inflammation via the CB2 receptor & the TLR4/NF-κB/MAPK signaling pathways β-Caryophyllene, a Dietary Phytocannabinoid, Alleviates Diabetic Cardiomyopathy in Mice by Inhibiting Oxidative Stress and Inflammation Activating Cannabinoid Type-2 Receptors https://pubmed.ncbi.nlm.nih.gov/37588762/