Best of cannabinoid science this week...
In a teenager with untreatable chronic pain from sickle cell disease, the dramatic efficacy of CBD to completely remove their pain Dramatic efficacy of cannabidiol on refractory chronic pain in an adolescent with sickle cell disease https://pubmed.ncbi.nlm.nih.gov/37540761/ And a case report of using THC to treat chronic pain Dronabinol Useful for Chronic Pain- A Case Report https://ideas.repec.org/a/abf/journl/v49y2023i2p40376-40379.html
A large case series of fibromyalgia patients showed cannabis to cause significant reductions in illness severity Self-Reported Effects of Medical Cannabis on Illness Severity, Depression and Anxiety in Fibromyalgia Patients: A Large Retrospective Case Series https://www.endocannabinoidmedicine.com/academicarticle/self-reported-effects-of-medical-cannabis-on-illness-severity-depression-and-anxiety-in-fibromyalgia-patients-a-large-retrospective-case-series/
A survey of those who exercise find that many consider cannabis & CBD to be helpful for the exercise recovery Cannabis use for exercise recovery in trained individuals: a survey study https://pubmed.ncbi.nlm.nih.gov/37542349/
In dementia patients, on cannabis reducing restlessness Cannabis dämpft die Unruhe bei Demenz [Cannabis reduces restlessness in dementia] https://pubmed.ncbi.nlm.nih.gov/37537470/
In adults with treatment resistant epilepsy, adding CBD hemp extracts for six months improved their quality of life & decreased their anxiety symptoms & adverse events An Observational Study of Adjunctive Artisanal Cannabidiol Use by Adults with Treatment Resistant Epilepsies: Behavioral and Urinalysis Data https://assets.researchsquare.com/files/rs-3214013/v1/65dd0f43-fa8b-4b9d-8988-24a54478ef6e.pdf?c=1691417815
A survey of chronic pain patients on how cannabis may be an off-ramp from prescription opioids Offering an Alternative to Persons with Chronic Pain: How Access to Cannabis May Provide an Off-Ramp from Undesired Prescription Opioid Use https://pubmed.ncbi.nlm.nih.gov/37484046/
In people using methadone for opioid use disorder, THC provided pain relief Delta-9-tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within-subject, randomized, placebo-controlled laboratory study https://pubmed.ncbi.nlm.nih.gov/37644897/
In a one year study of people with rotator cuff surgery, the use of CBD for pain control caused no functional deficits Cannabidiol for Post-Operative Pain Control after Arthroscopic Rotator Cuff Repair Demonstrates No Functional Deficits at 1-Year https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392481/
In public health data of middle-aged adults, a history of monthly cannabis use for more than one year was not associated with either increased blood pressure or hypertension Trends in Cannabis Use, Blood Pressure and Hypertension in Middle-Aged Adults: Findings from NHANES, 2009-2018, Corroon, et al https://pubmed.ncbi.nlm.nih.gov/37479221/
For multiple sclerosis, a review of clinical trials shows nabiximols (1:1 THC:CBD oil) to be a helpful add on for controlling spasticity Nabiximols is Efficient as Add-On Treatment for Patients with Multiple Sclerosis Spasticity Refractory to Standard Treatment: A Systematic Review and Meta-Analysis of Randomised Clinical Trials https://pubmed.ncbi.nlm.nih.gov/37519000/
A review on CBD's effect on metabolic syndrome The Use of Cannabidiol in Metabolic Syndrome-An Opportunity to Improve the Patient's Health or Much Ado about Nothing? https://pubmed.ncbi.nlm.nih.gov/37510734/
For neurodevelopmental disorders, a review of seven studies using CBD A systematic review of cannabidiol trials in neurodevelopmental disorders https://pubmed.ncbi.nlm.nih.gov/37543051/
For post-COVID olfactory dysfunction, a review of five studies finds the combination of PEA & luteolin (a flavonoid) to be an effective addition to conventional therapy Efficacy of Palmitoylethanolamide and Luteolin Association on Post-Covid Olfactory Dysfunction: A Systematic Review and Meta-Analysis of Clinical Studies https://pubmed.ncbi.nlm.nih.gov/37626685/
For cancer treatments, a review of using cannabinoids to treat the anorexia & cachexia Cannabinoids in the treatment of cancer anorexia and cachexia: Where have we been, where are we going? https://www.sciencedirect.com/science/article/pii/S2347562523001105 And a clinical trial showing that CBD can help with the side effects of tamoxifen without reducing its cancer fighting efficacy CBD-oil as a potential solution in case of severe tamoxifen-related side effects https://pubmed.ncbi.nlm.nih.gov/37543688/
In adolescent rats, long term CBD hemp extracts protected their hippocampus (a memory center of the brain) Long-Term Treatment with Cannabidiol-Enriched Cannabis Extract Induces Synaptic Changes in the Adolescent Rat Hippocampus https://pubmed.ncbi.nlm.nih.gov/37511537/
In older mice, a microdose of THC induced remarkably long lasting improvements in a wide range of cognitive functions
Hippocampal differential expression underlying the neuroprotective effect of delta-9-tetrahydrocannabinol microdose on old mice
In a rat model of obesity, CBD caused anti-inflammatory & antioxidative effects it appears to be a safe treatment for obesity- induced heart disease Therapeutic effect of cannabidiol on myocardial arachidonic acid content in various lipid fractions in a rat model of obesity https://pubmed.ncbi.nlm.nih.gov/37541613/
And in human small intestine cells, high CBD extracts inhibited levels of pro inflammatory factors via miRNA silencing High-CBD cannabis extracts inhibit the expression of proinflammatory factors via miRNA-mediated silencing in human small intestinal epithelial cells https://pubmed.ncbi.nlm.nih.gov/37664748/
In human skin cells, CBD helped to shift them to a more anti-inflammatory immune response The dual role of cannabidiol on monocyte-derived dendritic cell differentiation and maturation https://pubmed.ncbi.nlm.nih.gov/37680639/
In a rat model of adolescent binge drinking, CBD lowered their alcohol intake via CGRP & neuroendocrine signaling Cannabidiol tempers alcohol intake and neuroendocrine and behavioural correlates in alcohol binge drinking adolescent rats. Focus on calcitonin gene-related peptide's brain levels https://pubmed.ncbi.nlm.nih.gov/37525534/ And in mice, signaling by 2AG alters the effects of ethanol on synaptic transmission & behavior Striatonigral direct pathway 2-arachidonoylglycerol contributes to ethanol effects on synaptic transmission and behavior https://pubmed.ncbi.nlm.nih.gov/37528221/
In support of Dr. Raphael Mechoulam's pet theory on the endocannabinoids as a basis for personality, this study in mice suggests that “the endocannabinoid system may play a role in the regulation of dominance and submissiveness, functional elements of social behavior and personality” Endocannabinoid basis of personality-Insights from animal model of social behavior https://pubmed.ncbi.nlm.nih.gov/37663250/