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Research Roundup: Oct 4, 2021



Best of the Week...


A computational approach explains the mechanisms by which CBD might be helpful for osteoarthritis

Computational Approach Reveals Pronociceptive Potential of Cannabidiol in Osteoarthritis: Role of Transient Receptor Potential Channels

https://www.mdpi.com/1424-8247/14/10/964

In mice with atopic dermatitis, the beneficial effects of a Baikal skullcap extract (found in CV Acute) is mediated by the endocannabinoid system

ECS Modulating Effect of Scutellaria baicalensis Extract on inflammation relief in atopic dermatitis-induced mice

https://www.koreascience.or.kr/article/JAKO202126758039533.pdf

This review looks at the possibility of the endocannabinoid system being the cause & the solution to food addiction

Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution?

https://www.mdpi.com/1424-8247/14/10/1002

This speaks to the importance of our clinical research on our products helping people with their metabolism.

In horses, 100 mg of pelleted CBD per day for 6 weeks caused them to become less reactive to novel objects

The Effects of Pelleted CBD Supplementation on Heart Rate and Reaction Scores in Horses

https://www.sciencedirect.com/science/article/abs/pii/S1558787821001258

The use of CBD for horses is becoming more widespread & veterinary researchers are racing to find more data about how it works for them.


ProjectCBD on MRSA & CBD honey

https://www.projectcbd.org/wellness/bug-true-story-about-cbd-mrsa

A cool review of the trichomes of cannabis - the petite factories producing all of the cannabinoids & terpenes

Cannabis Glandular Trichomes: A Cellular Metabolite Factory

https://www.frontiersin.org/articles/10.3389/fpls.2021.721986/full


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

This review looks at how CBD might help with cognition in epilepsy

Cannabidiol (CBD) and cognition in epilepsy

https://pubmed.ncbi.nlm.nih.gov/34563808/

In humans, 20 minutes of exercise helped with pain & increased the circulating levels of endocannabinoids & endorphins

Aerobic exercise with blood flow restriction causes local and systemic hypoalgesia and increases circulating opioid and endocannabinoid levels

https://pubmed.ncbi.nlm.nih.gov/34498944/

In humans recovered from COVID-19, this review suggests endocannabinoid biomarkers that might serve as aids to the prognosis of obstructive sleep apnea

The Endocannabinoid System as Prognostic Biomarker of the Obstructive Sleep Apnea Morbidity in COVID-19-Recovered Individuals

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475390/

There’s lots early phase research suggesting CBD for acute COVID – but I suspect that it might be even more helpful for long COVID.

This review looks at the toxicological properties of THC & CBD

Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol

https://pubmed.ncbi.nlm.nih.gov/32597140/

A review of the ECS in the liver, how it relates to alcohol-associated liver disease & what treatments we might use

Hepatic Cannabinoid Signaling in the Regulation of Alcohol-Associated Liver Disease

https://arcr.niaaa.nih.gov/recovery-aud-part-2/hepatic-cannabinoid-signaling-regulation-alcohol-associated-liver-disease



Preclinical Research & Cannabinoid Chemistry

In tissue studies of COVID-19, cannabis extracts targeted the messenger RNA to slow viral replication, assembly & release

Targeting of Protein's Messenger RNA for Viral Replication, Assembly and Release in SARS-CoV-2 Using Whole Genomic Data From South Africa: Therapeutic Potentials of Cannabis Sativa L

https://pubmed.ncbi.nlm.nih.gov/34539415/

In a mouse that has CB2 receptors that glow in the dark, the amount of receptors present in the skin led the researchers to view the CB2 receptor as a target for the neuropathic pain of chemotherapy

A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy

https://journals.lww.com/pain/Abstract/9000/A_peripheral_CB2_cannabinoid_receptor_mechanism.97875.aspx

In a rat model of migraines, inhibiting both the FAAH enzyme (which breaks down anandamide) & the MAGL enzyme (that breaks down 2-AG) leads to less pain-associated behavior as well as gene activation related to inflammatory cytokines

Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine

https://www.mdpi.com/2073-4409/10/10/2543/htm

One important function of CBD is the inhibition of the FAAH enzyme, which raises levels of anandamide.

In this oldie but a goodie, a 1987 paper on how the cannabinoids activate the phospholipases

Activation of phospholipase A2 by cannabinoids. Lack of correlation with CNS effects

https://pubmed.ncbi.nlm.nih.gov/3803591/

In older mice, THC worked better alone for reversing spatial learning deficits than when combined with CBD because the presence of CBD caused more rapid clearance of the THC

Efficacy of Δ 9 -Tetrahydrocannabinol (THC) Alone or in Combination With a 1:1 Ratio of Cannabidiol (CBD) in Reversing the Spatial Learning Deficits in Old Mice

https://pubmed.ncbi.nlm.nih.gov/34526890/

Great molecular work looking at the CB1 receptor, how CBD binds to it & how that alters THC’s binding strength

Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol-A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling

https://pubmed.ncbi.nlm.nih.gov/33922473/