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Research Roundup: Oct 17, 2023



Best of cannabinoid science this week...


In two postmenopausal women with osteopenia (bone loss), 12 weeks of CBD reduced measured markers of bone turnover Oral Cannabidiol Treatment in Two Postmenopausal Women with Osteopenia: A Case Series https://pubmed.ncbi.nlm.nih.gov/37721991/#


In people at clinical high risk for psychosis, even one dose of CBD helped to normalize their hippocampal blood flow Increased Hippocampal Blood Flow in People at Clinical High Risk for Psychosis and Effects of Cannabidiol https://kclpure.kcl.ac.uk/portal/en/publications/increased-hippocampal-blood-flow-in-people-at-clinical-high-risk-


For dementia, THC from the dispensary improved symptoms for 80% of patients including agitation, aggression, irritability, lability, anxiety & insomnia as well as allowing half of them taking antipsychotics to lower or discontinue those medications The Use of Dispensary-Obtained Tetrahydrocannabinol as a Treatment for Neuropsychiatric Symptoms of Dementia https://pubmed.ncbi.nlm.nih.gov/37728481/


A survey of intensive care physicians finds the benefits of cannabinoids for critically ill patients “to reduce metabolic and psychological distress and to save medication”

Therapeutic Use of Cannabinoids in Critically Ill Patients: A Survey of Intensive Care Physicians in Germany


A clinical study on the efficacy of CBD for drug resistant epilepsy, regardless of its underlying cause or specific syndrome

Real-world evidence on the use of cannabidiol for the treatment of drug resistant epilepsy not related to Lennox-Gastaut syndrome, Dravet syndrome or Tuberous Sclerosis Complex


A survey finds that many people with cystic fibrosis are using cannabis & CBD Time To Be Blunt: Substance Use In Cystic Fibrosis https://europepmc.org/article/ppr/ppr727603


In dogs with osteoarthritis, 6 weeks of liposomal CBD reduced pain & increased well-being Therapeutic efficacy and pharmacokinetics of liposomal-cannabidiol injection: a pilot clinical study in dogs with naturally-occurring osteoarthritis https://pubmed.ncbi.nlm.nih.gov/37680386/ And here’s a study of how CBD moves through healthy dogs that shows how giving CBD twice a day lessens variations in CBD blood levels Cannabidiol plasma determination and pharmacokinetics conducted at beginning, middle and end of long-term supplementation of a broad-spectrum hemp oil to healthy adult dogs https://www.frontiersin.org/articles/10.3389/fvets.2023.1279926/full


A review of 18 studies on the topical use of cannabinoids for atopic dermatitis (eczema), dermatomyositis (muscle weakness & skin rash), psoriasis & systemic sclerosis (autoimmune connective tissue disorder) plus lower quality evidence for alopecia areata (hair loss from autoimmune attack against hair follicles), epidermolysis bullosa (fragile blistery skin), hyperhidrosis (excessive sweating), seborrheic dermatitis (scaly skin patches) & pruritus (itchiness) Cannabinoids for the Treatment of Hair, Scalp, and Skin Disorders: A Systematic Review https://www.mdpi.com/2079-9284/10/5/129


A summary of how acupuncture works via the endocannabinoid system Research progress of acupuncture mediated analgesia via regulating the function of endocannabinoid system https://pubmed.ncbi.nlm.nih.gov/37730267/


In β-cells (the synthesizers of insulin in the pancreas), the damaging exposure to high glucose & lipid levels were reduced by CBD, THCV, CBC & CBN, with CBD being the most effective Effect of THC, CBD, THCV, CBC and CBN Cannabinoids on β-Cells Exposed to High Glucose—High Lipids https://www.preprints.org/manuscript/202309.0973/v1


In a mouse model of neurodevelopmental disorders, CBD helped to restore the balance of excitation & inhibition in the prefrontal cortex via glutamate, GABA & the GPR55 receptors Restoring prefrontal cortical excitation-inhibition balance with cannabidiol ameliorates neurobehavioral abnormalities in a mouse model of neurodevelopmental disorders https://pubmed.ncbi.nlm.nih.gov/37716533/


In 2 mouse models of a mitochondrial diseases (the powerhouse of the cell), CBD delayed their motor decline & neurodegenerative signs, improved social deficits & breathing abnormalities, decreased thermally induced seizures & improved neuropathology Cannabidiol ameliorates mitochondrial disease via PPARγ activation https://assets.researchsquare.com/files/rs-3231021/v1_covered_e0002203-4440-4ae9-9067-f52a2363c44f.pdf?c=1695142938


In rats who had a heart attack, eight weeks of CBD oil & swimming increased the anandamide levels in their heart & reduced heart damage The effect of eight weeks of cannabidiol oil consumption and swimming training on the expression of the anandamide (AEA) gene in heart tissue of rats suffering from myocardial infarction https://journals.iau.ir/article_705955_126ad7c12ccf2686fbc2884cfc133c31.pdf


A 90-day rat toxicity study of a CBD isolate

Subchronic oral toxicity assessment of a cannabis extract


In a rat model of anxiety, some of the terpenes & minor cannabinoids showed anti-anxiety effects

Evaluating Potential Anxiolytic Effects of Minor Cannabinoids and Terpenes After Acute and Chronic Oral Administration in Rats


In a young zebrafish model of seizures, CBD, CBC & CBN reduced seizures at low doses via the GPR55 receptors as well as regulating the expression of endocannabinoids Phytocannabinoids Reduce Seizures in Larval Zebrafish and Affect Endocannabinoid Gene Expression https://pubmed.ncbi.nlm.nih.gov/37759798/


In intestinal cells, CBD lowered inflammation & protected the intestinal barrier Cannabidiol attenuates inflammatory impairment of intestinal cells expanding biomaterial-based therapeutic approaches https://pubmed.ncbi.nlm.nih.gov/37779918/


In animal models, the efficacy of topical 1% CBD gel for painkilling & anti-inflammation Analgesic and Anti-Inflammatory Effects of 1% Topical Cannabidiol Gel in Animal Models https://pubmed.ncbi.nlm.nih.gov/37669453/


Using a CBD sponge for wound healing Fabrication and characterization of new levan@CBD biocomposite sponges as potential materials in natural, non-toxic wound dressing applications https://pubmed.ncbi.nlm.nih.gov/37722631/

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