Best of cannabinoid science this week...
In a Florida survey of medical cannabis patients, 79% reported a reduction in their pain medication use Medical Cannabis Patients Report Improvements in Health Functioning and Reductions in Opiate Use https://pubmed.ncbi.nlm.nih.gov/36168127
In humans, a pilot study showed that THC helped to extinguish fear conditioning induced by visual stimuli & electric shocks
Facilitated extinction of conditioned fear responses by delta 9-tetrahyrdrocannabidol in humans: a pilot study
Targeting the ECS for the pain of irritable bowel syndrome Targeting the endocannabinoid system for the treatment of abdominal pain in irritable bowel syndrome https://pubmed.ncbi.nlm.nih.gov/36168049
A review found that across all trials they looked at for the nausea & vomiting of chemotherapy, cannabis worked better than conventional antiemetics
Pharmacotherapeutic Considerations for Use of Cannabinoids to Relieve Symptoms of Nausea and Vomiting Induced by Chemotherapy
In the treatment of fibromyalgia, a review of 10 studies found that cannabis may be beneficial to patients & that no serious adverse events occurred Safety and Efficacy of Medicinal Cannabis in the Treatment of Fibromyalgia: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/33337931
2021: In a mouse model of colitis, THC prevented the disease via the immune cells & colon cells while CBD, at the doses tested, did not Cannabinoid Receptor Activation on Haematopoietic Cells and Enterocytes Protects against Colitis https://pubmed.ncbi.nlm.nih.gov/33331878
In a rodent model of opioid use disorder, a negative allosteric modulator of the CB1 receptor (similar to CBD) blocked the rewarding effects of morphine & reduced consumption of oxycodone Negative allosteric modulation of CB1 cannabinoid receptor signaling suppresses opioid-mediated reward https://pubmed.ncbi.nlm.nih.gov/36179954
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