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Research Roundup: Oct 10, 2022



Best of cannabinoid science this week...


A review of 34 studies of using CBD (& equal levels of THC) for insomnia Use of Cannabidiol in the Management of Insomnia: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/36149724 & a review of CBD for sleep disorders caused by other illnesses Cannabidiol in the context of sleeping disorders-induced oxidative stress https://ojs.actamedicamarisiensis.ro/index.php/amm/article/view/182


A review of the neuroprotective effects of CBD against neurological disorders & neuroinflammation regulated by the microglia (the guardian immune cells of the brain) Neuroprotection of Cannabidiol, Its Synthetic Derivatives and Combination Preparations against Microglia-Mediated Neuroinflammation in Neurological Disorders https://pubmed.ncbi.nlm.nih.gov/35956911


On using CBD to treat Parkinson’s disease (Portuguese & English) Uso de Canabidiol como tratamento para a Doença de Parkinson https://brazilianjournals.com/ojs/index.php/BJHR/article/view/52267


In a mouse model of fibromyalgia, cannabis oil with low THC levels helped with pain & touch sensitivities as well as lessening depressive behaviors Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice https://pubmed.ncbi.nlm.nih.gov/35988425


In skin connective tissue cells, combining CBD with common nutrient treatments (such as resveratrol from wine) increased their viability & wound-healing functionality as well as reducing their metabolic dysfunction The Effects of Nutrient Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Phenotype in Human Dermal Fibroblasts https://pubmed.ncbi.nlm.nih.gov/35955938


In a mouse model of sickle cell anemia, CBD lowered their sensitivity to pain Cannabidiol attenuates hyperalgesia in a mouse model of sickle cell disease https://pubmed.ncbi.nlm.nih.gov/36122382 There’s not a ton of research on cannabinoids for sickle cell anemia, but there’s enough positive stuff like this out there that I think people should give it a try.


In a mouse model of neuropathic pain, a spinal cord pump of CBD & THC reduced their mechanical & cold sensitivities while causing no psychoactive effects Intrathecal Actions of the Cannabis Constituents Δ(9)-Tetrahydrocannabinol and Cannabidiol in a Mouse Neuropathic Pain Model https://pubmed.ncbi.nlm.nih.gov/35955774

In songbirds with brain damage, we already knew that CBD helped them to recovery their singing ability – and then this research demonstrates that a low dose of THC helps the CBD to work better while a high dose of THC slows down the CBD’s ability to cause recovery

Δ9-Tetrahydrocannabinol Differentially Alters Cannabidiol Efficacy in Recovery of Phonology and Syntax Following Damage to a Songbird Cortical-Like Brain Region


On using CBD/CBDA paste to treat seizures in dogs

Safety and efficacy of cannabidiol-cannabidiolic acid rich hemp extract in the treatment of refractory epileptic seizures in dogs


Cannabinoids from the plant have higher antioxidant power than the isolated synthetic cannabinoids Natural vs. artificial cannabinoid oils: the comparison of their antioxidant activities https://pubmed.ncbi.nlm.nih.gov/36164439


Computer modeling on why CBD helps with seizures Investigation of cannabidiol's potential targets in limbic seizures. In-silico approach https://pubmed.ncbi.nlm.nih.gov/36129109

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