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Research Roundup: Oct 10, 2022



Best of cannabinoid science this week...


A review of 34 studies of using CBD (& equal levels of THC) for insomnia Use of Cannabidiol in the Management of Insomnia: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/36149724 & a review of CBD for sleep disorders caused by other illnesses Cannabidiol in the context of sleeping disorders-induced oxidative stress https://ojs.actamedicamarisiensis.ro/index.php/amm/article/view/182


A review of the neuroprotective effects of CBD against neurological disorders & neuroinflammation regulated by the microglia (the guardian immune cells of the brain) Neuroprotection of Cannabidiol, Its Synthetic Derivatives and Combination Preparations against Microglia-Mediated Neuroinflammation in Neurological Disorders https://pubmed.ncbi.nlm.nih.gov/35956911


On using CBD to treat Parkinson’s disease (Portuguese & English) Uso de Canabidiol como tratamento para a Doença de Parkinson https://brazilianjournals.com/ojs/index.php/BJHR/article/view/52267


In a mouse model of fibromyalgia, cannabis oil with low THC levels helped with pain & touch sensitivities as well as lessening depressive behaviors Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice https://pubmed.ncbi.nlm.nih.gov/35988425


In skin connective tissue cells, combining CBD with common nutrient treatments (such as resveratrol from wine) increased their viability & wound-healing functionality as well as reducing their metabolic dysfunction The Effects of Nutrient Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Phenotype in Human Dermal Fibroblasts https://pubmed.ncbi.nlm.nih.gov/35955938


In a mouse model of sickle cell anemia, CBD lowered their sensitivity to pain Cannabidiol attenuates hyperalgesia in a mouse model of sickle cell disease https://pubmed.ncbi.nlm.nih.gov/36122382 There’s not a ton of research on cannabinoids for sickle cell anemia, but there’s enough positive stuff like this out there that I think people should give it a try.


In a mouse model of neuropathic pain, a spinal cord pump of CBD & THC reduced their mechanical & cold sensitivities while causing no psychoactive effects Intrathecal Actions of the Cannabis Constituents Δ(9)-Tetrahydrocannabinol and Cannabidiol in a Mouse Neuropathic Pain Model https://pubmed.ncbi.nlm.nih.gov/35955774

In songbirds with brain damage, we already knew that CBD helped them to recovery their singing ability – and then this research demonstrates that a low dose of THC helps the CBD to work better while a high dose of THC slows down the CBD’s ability to cause recovery

Δ9-Tetrahydrocannabinol Differentially Alters Cannabidiol Efficacy in Recovery of Phonology and Syntax Following Damage to a Songbird Cortical-Like Brain Region

https://pubmed.ncbi.nlm.nih.gov/36125410


On using CBD/CBDA paste to treat seizures in dogs

Safety and efficacy of cannabidiol-cannabidiolic acid rich hemp extract in the treatment of refractory epileptic seizures in dogs

https://pubmed.ncbi.nlm.nih.gov/35967998


Cannabinoids from the plant have higher antioxidant power than the isolated synthetic cannabinoids Natural vs. artificial cannabinoid oils: the comparison of their antioxidant activities https://pubmed.ncbi.nlm.nih.gov/36164439


Computer modeling on why CBD helps with seizures Investigation of cannabidiol's potential targets in limbic seizures. In-silico approach https://pubmed.ncbi.nlm.nih.gov/36129109