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Research Roundup: Nov 8, 2022



Best of cannabinoid science this week...


In people with moderate to severe anxiety, a sublingual CBD solution for four weeks improved anxiety, mood, sleep, quality of life & cognition (hattip to Col. Dr. Michael Lewis) Clinical and cognitive improvement following full-spectrum, high-cannabidiol treatment for anxiety: open-label data from a two-stage, phase 2 clinical trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628346

And in a mouse model of stress & depression caused by trauma, cannabis oil improved their symptoms related to anxiety & depression Broad-Spectrum Cannabis Oil Alleviates Behavioral Symptoms Associated with Stress-Related Anxiety and Depression in Mice https://ps.tbzmed.ac.ir/Article/ps-34488


A great study about your genetic variants for the ECS affect how effective cannabis is for treating your pain The Pharmacogenetics of Cannabis in the Treatment of Chronic Pain https://pubmed.ncbi.nlm.nih.gov/36292717


In a rat model of neuropathic pain, THC worked the best for reducing pain – but high-CBD cannabis extracts was more effective than CBD alone Combinations of Cannabidiol and Δ9-Tetrahydrocannabinol in Reducing Chemotherapeutic Induced Neuropathic Pain https://pubmed.ncbi.nlm.nih.gov/36289810


In mice, PEA combined well with melatonin & paracetamol to reduce pain Melatonin synergizes with the antinociceptive effect of N-palmitoylethanolamide and paracetamol https://pubmed.ncbi.nlm.nih.gov/36199181


In COVID patients, their smell & taste dysfunctions may be linked to a dysregulation of their endocannabinoid system Possible Role of Endocannabinoids in Olfactory and Taste Dysfunctions in COVID-19 Patients and Volumetric Changes in the Brain https://pubmed.ncbi.nlm.nih.gov/36247977


A review of using cannabinoids against microbes Antimicrobial and Cytotoxic Effects of Cannabinoids: An Updated Review with Future Perspectives and Current Challenges https://pubmed.ncbi.nlm.nih.gov/36297340 Using cannabinoids against our bacterial adversaries is one of the most important & under-utilized aspects of their nature!


A review of CBD & other non-psychoactive cannabinoids for GI tract disorders Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals? https://pubmed.ncbi.nlm.nih.gov/32357565


A big review of the gender differences in response to CBD

Sex Differences in the Neuropsychiatric Effects and Pharmacokinetics of Cannabidiol: A Scoping Review

https://pubmed.ncbi.nlm.nih.gov/36291671


A look at how anandamide & 2-AG cause long-term potentiation (a persistent increase in synaptic strength) in the hippocampus (memory center of the brain) via inhibition of the neurons using GABA 2-AG and anandamide enhance hippocampal long-term potentiation via suppression of inhibition https://pubmed.ncbi.nlm.nih.gov/36212685


How beta-caryophyllene (one of the most common terpenes in cannabis) functions as a brain anti-inflammatory via several different pathways Anti-Inflammatory Effect of Beta-Caryophyllene Mediated by the Involvement of TRPV1, BDNF and trkB in the Rat Cerebral Cortex after Hypoperfusion/Reperfusion https://pubmed.ncbi.nlm.nih.gov/35408995