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Research Roundup: Nov 7, 2023



Best of cannabinoid science this week...


A survey of why people are using CBD listed neurological disorders, pulmonary conditions, gastrointestinal disorders & chronic pain Consumer perception, knowledge, and uses of cannabidiol https://meridian.allenpress.com/mhc/article/13/5/217/496172


A double-blind placebo sleep study finds CBN to be helpful for improving overall sleep disturbance A Double-Blind, Randomized, Placebo-Controlled Study of the Safety and Effects of CBN With and Without CBD on Sleep Quality https://psycnet.apa.org/fulltext/2024-14146-001.pdf


In older adults, medical cannabis use was not associated with a decrease in daily living activities Medical Cannabis Is Not Associated with a Decrease in Activities of Daily Living in Older Adults https://www.mdpi.com/2227-9059/11/10/2697


A personal case report on using cannabis for anxiety An Individual's Lived Experiences of Taking Cannabis-Based Medicinal Products (CBMPs) to Treat Anxiety https://pubmed.ncbi.nlm.nih.gov/37754635/


In a survey, caregivers endorsed CBD as helpful for Angelman syndrome (a genetic disorder that leads to developmental delays as well as happy, excitable personalities) Quality of Life in Angelman Syndrome: A Caregivers' Survey https://pubmed.ncbi.nlm.nih.gov/37757661/


In a case report of a person with Fabry disease (a genetic neurological disorder that causes pain & a variety of symptoms), cannabis helped to relieve their nocturnal neuropathic pain when nothing else would Relief of nocturnal neuropathic pain with the use of cannabis in a patient with Fabry disease https://www.sciencedirect.com/science/article/pii/S2214426923000563


In adults with drug-resistant epilepsies, the safety & efficacy of CBD High-purified cannabidiol efficacy and safety in a cohort of adult patients with various types of drug-resistant epilepsies https://pubmed.ncbi.nlm.nih.gov/37806886/


In dogs with osteoarthritis, an analysis of the endocannabinoid system at their joints indicates a therapeutic use for cannabinoid medicines Endocannabinoid System Receptors at the Hip and Stifle Joints of Middle-Aged Dogs: A Novel Target for the Therapeutic Use of Cannabis sativa Extract in Canine Arthropathies https://pubmed.ncbi.nlm.nih.gov/37760233/


A big review of 59 studies on CBD & cognition find no impairment Effects of the Acute and Chronic Administration of Cannabidiol on Cognition in Humans and Animals: A Systematic Review https://www.liebertpub.com/doi/abs/10.1089/can.2023.0086


A collection of the data on CBD & inflammation

Effects of Cannabidiol in Inflammation: A Review of Pre-clinical and Clinical Findings


A review of the history & chemistry of cannabis From ancient Asian relics to contemporaneity: A review of historical and chemical aspects of Cannabis https://www.eurjchem.com/index.php/eurjchem/article/view/2442


On how exercise interacts with your endocannabinoid system & kynurenine pathway as well as the potential relevance for depression & obesity Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms https://pubmed.ncbi.nlm.nih.gov/37895892/


On cannabinoids for kidney & liver toxicity Cannabinoids as Potential Therapeutic Agents for Kidney and Liver Toxicity https://journals.ekb.eg/article_319056_c86b5a72e96ad3102413426b637cc48d.pdf

And in rat liver cells, the presence of CBG lowered fibrosis (scar tissue) Concentration-Dependent Attenuation of Pro-Fibrotic Responses after Cannabigerol Exposure in Primary Rat Hepatocytes Cultured in Palmitate and Fructose Media https://pubmed.ncbi.nlm.nih.gov/37759466/


In a mouse model of obesity, five weeks of THC lessened weight gain & improved their glucose tolerance while five weeks of CBD increased lipid metabolism in fat & liver tissues as well as improving glucose tolerance The Effect of Orally Administered Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) on Obesity Parameters in Mice https://pubmed.ncbi.nlm.nih.gov/37762099/


In human microglial cells (white blood cells that eat invaders), the anti-inflammatory effects of the minor cannabinoids

Anti-Inflammatory Effects of Minor Cannabinoids CBC, THCV, and CBN in Human Macrophages


In a new hemp cultivar called Pink Pepper, the CBD from it has anti-inflammatory effects In Vitro and In Vivo Anti-Inflammatory Effects of Cannabidiol Isolated from Novel Hemp ( Cannabis sativa L.) Cultivar Pink Pepper https://pubmed.ncbi.nlm.nih.gov/37764215/


In tilapia fish, CBD lowered stress biomarkers Effects of CBD (Cannabidiol) on the physiology of Nile tilapia (Oreochromisn niloticus) as a chronic stress mitigating agent In-vivo https://pubmed.ncbi.nlm.nih.gov/37713426/

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