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Research Roundup: Nov 22, 2022



Best of cannabinoid science this week...


In a study of long COVID, one month of a CBD-rich cannabis extract formulation improved their scores A Single-Blind, Randomized, Placebo Controlled Study to Evaluate the Benefits and Safety of Endourage Targeted Wellness Formula C Sublingual +Drops in People with Post-Acute Coronavirus Disease 2019 Syndrome https://pubmed.ncbi.nlm.nih.gov/36252151


In patients with multiple sclerosis & a spasticity resistant to treatment, a 1:1 THC:CBD spray caused 60% to have clinically relevant symptomatic effects Sativex® (nabiximols) cannabinoid oromucosal spray in patients with resistant multiple sclerosis spasticity: the Belgian experience https://pubmed.ncbi.nlm.nih.gov/34157999


In kids with autism, CBD-rich cannabis extracts for 6 months most showed improvement in repetitive behaviors & social communication abilities, especially those with more severe starting symptoms Children and adolescents with ASD treated with CBD-rich cannabis exhibit significant improvements particularly in social symptoms: an open label study https://pubmed.ncbi.nlm.nih.gov/36085294


In autism, a review of why the endocannabinoid control of lipid signaling helps to balance inflammation & oxidation & why this makes it a treatment target Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder https://pubmed.ncbi.nlm.nih.gov/36077195


A systematic study of CBD safety Cannabidiol Safety Data: A Systematic Mapping Study https://pubmed.ncbi.nlm.nih.gov/36251454


A survey of singers finds that they use CBD for stress, anxiety or chronic pain Alternative and Complimentary Medication Use in Singers: A Pilot Survey https://pubmed.ncbi.nlm.nih.gov/36270919


A look at how CBD promotes new brain cell growth via the Akt & Erk pathways & the CB1 receptor Cannabidiol Promotes Neuronal Differentiation Using Akt and Erk Pathways Triggered by Cb1 Signaling https://pubmed.ncbi.nlm.nih.gov/36080415


In a neuronal model of blood loss to the brain, CBD caused its benefits via lowering the amount of CB2/serotonin heteromer complexes (two receptors joined together) Regulation of Expression of Cannabinoid CB2 and Serotonin 5HT1A Receptor Complexes by Cannabinoids in Animal Models of Hypoxia and in Oxygen/Glucose-Deprived Neurons https://pubmed.ncbi.nlm.nih.gov/36077095


In a mouse model of stroke, CBD prevented neurological impairment, reduced neural deficits & protected against neurodegeneration Cannabidiol Exerts a Neuroprotective and Glia-Balancing Effect in the Subacute Phase of Stroke https://www.mdpi.com/1422-0067/23/21/12886


A review of the evidence for low doses of isolated CBD (below 400 mg per day) finds help for anxiety & anti-addiction as well as less strong evidence for insomnia, neurological disorders & chronic pain

The safety and efficacy of low oral doses of cannabidiol: An evaluation of the evidence

https://pubmed.ncbi.nlm.nih.gov/36259271


In a rat model of sciatic nerve damage, PEA decreased the intensity & duration of the pain, stabilized the microglia & astroglia (brain immune cells) & lowered neuroinflammation by several mechanisms Analgesic Activity of Palmitoylethanolamide on Neuropathic Pain in Rats https://link.springer.com/article/10.1134/S1819712422030047


In fat stem cells, treating them with CBD protected against oxidative stress by the reduction of inflammation, enhanced their proliferation & lowered apoptosis (cellular suicide) Cannabidiol (CBD) Protects Adipose-Derived Mesenchymal Stem Cells (ASCs) against Endoplasmic Reticulum Stress Development and Its Complications https://pubmed.ncbi.nlm.nih.gov/36078578