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Research Roundup: Nov 22, 2022

Best of cannabinoid science this week...

In a study of long COVID, one month of a CBD-rich cannabis extract formulation improved their scores A Single-Blind, Randomized, Placebo Controlled Study to Evaluate the Benefits and Safety of Endourage Targeted Wellness Formula C Sublingual +Drops in People with Post-Acute Coronavirus Disease 2019 Syndrome

In patients with multiple sclerosis & a spasticity resistant to treatment, a 1:1 THC:CBD spray caused 60% to have clinically relevant symptomatic effects Sativex® (nabiximols) cannabinoid oromucosal spray in patients with resistant multiple sclerosis spasticity: the Belgian experience

In kids with autism, CBD-rich cannabis extracts for 6 months most showed improvement in repetitive behaviors & social communication abilities, especially those with more severe starting symptoms Children and adolescents with ASD treated with CBD-rich cannabis exhibit significant improvements particularly in social symptoms: an open label study

In autism, a review of why the endocannabinoid control of lipid signaling helps to balance inflammation & oxidation & why this makes it a treatment target Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder

A systematic study of CBD safety Cannabidiol Safety Data: A Systematic Mapping Study

A survey of singers finds that they use CBD for stress, anxiety or chronic pain Alternative and Complimentary Medication Use in Singers: A Pilot Survey

A look at how CBD promotes new brain cell growth via the Akt & Erk pathways & the CB1 receptor Cannabidiol Promotes Neuronal Differentiation Using Akt and Erk Pathways Triggered by Cb1 Signaling

In a neuronal model of blood loss to the brain, CBD caused its benefits via lowering the amount of CB2/serotonin heteromer complexes (two receptors joined together) Regulation of Expression of Cannabinoid CB2 and Serotonin 5HT1A Receptor Complexes by Cannabinoids in Animal Models of Hypoxia and in Oxygen/Glucose-Deprived Neurons

In a mouse model of stroke, CBD prevented neurological impairment, reduced neural deficits & protected against neurodegeneration Cannabidiol Exerts a Neuroprotective and Glia-Balancing Effect in the Subacute Phase of Stroke

A review of the evidence for low doses of isolated CBD (below 400 mg per day) finds help for anxiety & anti-addiction as well as less strong evidence for insomnia, neurological disorders & chronic pain

The safety and efficacy of low oral doses of cannabidiol: An evaluation of the evidence

In a rat model of sciatic nerve damage, PEA decreased the intensity & duration of the pain, stabilized the microglia & astroglia (brain immune cells) & lowered neuroinflammation by several mechanisms Analgesic Activity of Palmitoylethanolamide on Neuropathic Pain in Rats

In fat stem cells, treating them with CBD protected against oxidative stress by the reduction of inflammation, enhanced their proliferation & lowered apoptosis (cellular suicide) Cannabidiol (CBD) Protects Adipose-Derived Mesenchymal Stem Cells (ASCs) against Endoplasmic Reticulum Stress Development and Its Complications


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