Best of cannabinoid science this week...
In public health data from Pennsylvania, people using medical cannabis for anxiety or PTSD after three months had lessened anxiety & reported reduction in medication usage, especially benzodiazepines Anxiety severity and prescription medication utilization in first-time medical marijuana users https://www.sciencedirect.com/science/article/pii/S2666915323002093
On PEA as an anti-inflammatory & immune system modulator Therapeutic Use of Palmitoylethanolamide as an Anti-inflammatory and Immunomodulator https://www.preprints.org/manuscript/202310.0675/v1
During the recent outbreak of nipah virus in India, the use of cannabis oil as an antiviral mouthwash & oral treatment as well as the consumption of hemp seeds & oil as functional foods Cannabis sativa: 2023-Outbreak and Re-emergence of Nipah virus (NiV) in India: Role of Hemp oil https://www.researchgate.net/profile/Ravindra-Malabadi/publication/374581589_Cannabis_sativa_2023-Outbreak_and_Re-emergence_of_Nipah_virus_NiV_in_India_Role_of_Hemp_oil/links/65256018c64260390bde8897/Cannabis-sativa-2023-Outbreak-and-Re-emergence-of-Nipah-virus-NiV-in-India-Role-of-Hemp-oil.pdf
For gynecological pain, a review of using the cannabinoids with 50% reporting a reduction or cessation of painkiller usage The Place of Cannabinoids in the Treatment of Gynecological Pain https://link.springer.com/article/10.1007/s40265-023-01951-z “Cannabis consumers report substantial reductions in pelvic pain, as well as common comorbid symptoms such as gastrointestinal disturbances, mood disorders such as anxiety and depression, and poor sleep. Substitution effects were reported, with >50% reduction or cessation in opioid and/or non-opioid analgesics being the most common.”
For neurological disorders, a review of the therapeutic potential of CBD Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review https://pubmed.ncbi.nlm.nih.gov/37868743/
A review of 62 articles using CBD for improving sports performance & metabolic modulation Effects of cannabidiol on metabolic modulation and improving sports performance: a systematic review
For the acute respiratory distress of COVID-19, a review on the potential of using CBD as an early-intervention immunomodulator with anti-inflammatory properties The Potential of Cannabidiol for Acute Respiratory Distress Syndrome in COVID-19 https://pubmed.ncbi.nlm.nih.gov/37818584/
A guide to CBD for mental health professionals Easy as CBD: A cannabidiol primer for mental health professionals https://psycnet.apa.org/record/2024-17861-001
In infectious diseases, a big free book on many aspects of cannabinoids CANNABINOIDS IN INFECTIOUS DISEASES https://www.researchgate.net/publication/370714168_CANNABINOIDS_IN_INFECTIOUS_DISEASES
For oralfacial pain, a review of targeting the endocannabinoid system The endocannabinoid system and orofacial pains: updates and perspectives https://www.scielo.br/j/brjp/a/FrgwcM5LJ4xnvYkBPZggc8g/
On social anxiety disorder, a review of 18 studies find that while CBD & THC can be helpful at certain doses, they can increase anxiety at other doses Subjective, behavioral and neurobiological effects of cannabis and cannabinoids in social anxiety https://pubmed.ncbi.nlm.nih.gov/37812748/
A review on the use of CBD for pediatric epilepsy Cannabidiol for the Treatment of Pediatric Epilepsy https://pubmed.ncbi.nlm.nih.gov/37820705/
CBD seemed to protect from neonatal brain damage via protein carbonylation Protein Carbonylation as a Biomarker of Oxidative Stress and a Therapeutic Target in Neonatal Brain Damage https://www.mdpi.com/2076-3921/12/10/1839
In a rat model of aging, chronic treatment with CBD protected the lungs & liver by reducing mediators of inflammation, oxidation & apoptosis (programmed cellular suicide) Protective Actions of Cannabidiol on Aging-Related Inflammation, Oxidative Stress and Apoptosis Alterations in Liver and Lung of Long Evans Rats https://pubmed.ncbi.nlm.nih.gov/37891916/
In a rat model of memory loss from topiramate (a drug to treat brain diseases), CBD protected memory via the hippocampus & frontal cortex glutamate receptors & CREB/BDNF signaling Ameliorative Effect of Cannabidiol on Topiramate-Induced Memory Loss: The Role of Hippocampal and Prefrontal Cortical NMDA Receptors and CREB/BDNF Signaling Pathways in Rats https://pubmed.ncbi.nlm.nih.gov/37814133/
In a mouse model of acute lung injury, CBD reduced systemic & pulmonary inflammation but did cause a slightly higher acute lung injury score Cannabidiol Reduces Systemic Immune Activation in Experimental Acute Lung Injury https://www.liebertpub.com/doi/abs/10.1089/can.2023.0039
In a mouse model of neuropathic pain from chemotherapy, two weeks of CBG significantly reduced pain hypersensitivity without the formation of tolerance Chronic Cannabigerol as an Effective Therapeutic for Cisplatin-Induced Neuropathic Pain https://pubmed.ncbi.nlm.nih.gov/37895913/
In a rat model of liver toxicity, cannabis extracts protected against damage HISTOPATHOLOGICAL, ANTIOXIDANTS, BIOCHEMICAL EXAMINATION AND HEPATOPROTECTIVE EFFECTS OF CANNABIS SATIVA AGAINST CCL4 INDUCED TOXICITY IN RATS https://jptcp.com/index.php/jptcp/article/view/3073
In a tissue model of non alcoholic fatty liver disease, CBD reduced fatty acid accumulation & inhibited the differentiation of fat stem cells Cannabidiol and Indole-3-carbinol Reduce Intracellular Lipid Droplet Accumulation in HepaRG, A Human Liver Cell Line, as well as in Human Adipocytes https://www.ingentaconnect.com/content/ben/npj/2024/00000014/00000002/art00006
In livestock guts, CBD helped to lower inflammation Immunomodulation by cannabidiol in bovine primary ruminal epithelial cells https://pubmed.ncbi.nlm.nih.gov/37845710/