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Research Roundup: May 28, 2024



Best of cannabinoid science this week...


In people with multiple sclerosis, those using medical cannabis improved on the scales of cognitive function, mental health, sexual function & general health-related quality of life

Clinical outcome analysis of patients with multiple sclerosis - Analysis from the UK Medical Cannabis Registry

 

In females with challenges in achieving orgasm, cannabis use before partner sex increased orgasm frequency & orgasm satisfaction

Assessment of the effect of cannabis use before partnered sex on women with and without orgasm difficulty


In people with toothache, CBD an effective painkiller

Cannabidiol - an effective analgesic for toothache?https://pubmed.ncbi.nlm.nih.gov/38649735/

 

For people with osteoarthritis, cannabis-based medicines improved their pain

Assessment of Clinical Outcomes in Patients With Osteoarthritis: Analysis From the UK Medical Cannabis Registry

 

A survey of families using cannabis for their autistic children found a high adherence rate to treatment & substantial reported benefits

Characteristics for Medical Cannabis Treatment Adherence among Autistic Children and Their Families: A Mixed-Methods Analysis


In German people using cannabinoid medicines, the most frequent reasons for use were pain, sleep disturbance, stress/tension, inner restlessness, depressive mood & muscle tension with 84% reporting a significant improvement to quality of life

Patient-reported outcomes in chronic diseases under treatment with cannabis medicines : Analysis of the results of the Copeia survey

 

A case study of five patients where cannabis extracts reduced their pain, spasticity & inflammation

The effect of full-spectrum cannabis leaf extract on pain, inflammation, and quality of sleep: Case series


For fibromyalgia symptoms, a review of the evidence for medical cannabis

Is Medical Cannabis a Solution for Controlling Fibromyalgia Symptoms?https://pubmed.ncbi.nlm.nih.gov/38569807/

 


A review of using cannabinoids for lung infections including COVID, flu, pneumonia, respiratory syncytial virus & haemophilus influenza type b (Hib)

Cannabis effectiveness on immunologic potency of pulmonary contagion

 

For ulcerative colitis, a review of four studies found cannabinoids improved disease activity

Therapeutic Effects of Cannabinoids on Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

 

Two reviews of CBD for heart problems

Therapeutic potential of cannabidiol (CBD) in the treatment of cardiovascular diseases

A Systematic Review of Cannabidiol Effects in Coronary Syndromes: Challenges to Clinical Translation

 

A review of the targets of CBD, THC, anandamide & 2AG

A review of the direct targets of the cannabinoids cannabidiol, Δ9-tetrahydrocannabinol, N-arachidonoylethanolamine and 2-arachidonoylglycerol


A review of using hemp extracts against arthritis & diabetes

Tapping the nutraceutical potential of industrial hemp against arthritis and diabetes - A comprehensive review

 

For opioid use disorder, a review of treating it with medical cannabis

The Role of Medicinal Cannabis as an Emerging Therapy for Opioid Use Disorder


In mice, moderate doses of cannabis improved their learning & memory in neurobehavioral tests

Cannabis sativa Boosts Brain Functions and Ameliorate Anxiety, when used Sensibly and not Abusively

 

In a mouse model of autism, CBD lessened their repetitive self-grooming & hyperlocomotion behaviors as well as their social deficits

Cannabidiol is a behavioral modulator in BTBR mouse model of idiopathic autism

 

In a mouse model of neuropathic pain from diabetes, the combination of CBD & the terpene beta caryophyllene prevented deterioration of the mitochondria (powerhouse of the cell) & reduced pain hypersensitivity

Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/SIRT3/Nrf2 Axis

 

In a mouse model of methamphetamine use disorder, CBD helped to make behavioral changes via RNA networks

Identification of the circRNA-miRNA-mRNA network for treating methamphetamine-induced relapse and behavioral sensitization with cannabidiol

 

In a rat model of spinal fusion surgery, CBD & THC had no adverse effect on bone healing or spinal fusion rates & may have even enhanced bone healing

The effect of cannabinoids on single-level lumbar arthrodesis outcomes in a rat model


In a mouse model of PTSD, CBD alleviated their PTSD-like behaviors via changes to the expression of over 60 genes

Single-Nucleus Transcriptome Profiling from the Hippocampus of a PTSD Mouse Model and CBD-Treated Cohorts

"A total of 63 overlapping genes in InNs were identified as key genes for CBD in the treatment of PTSD. Subsequent Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed that the anti-PTSD effect of CBD was related to the regulation of protein synthesis, oxidative phosphorylation, oxidative stress response, and fear response.”

 

In a mouse model of cocaine use disorder, CBD reduced interest in cocaine & improved the lost gut microbial diversity

Cannabidiol (CBD) facilitates cocaine extinction and ameliorates cocaine-induced changes to the gut microbiome in male C57BL/6JArc mice


In a rat safety study of oleoylethanolamide, large acute doses or chronic administration cause no significant adverse alterations except for increased liver weight & ALT levels

A Comprehensive Safety Profile of Oleoylethanolamide

https://www.scivisionpub.com/pdfs/a-comprehensive-safety-profile-of-oleoylethanolamide-3241.pdf“Based on the above results, OEA is considered to be safe up to dosage at 2500 mg/kg b.wt./day body weight and can be further developed for future applications.”

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