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Research Roundup: May 24, 2021




Best of the Week...

This survey of patients with fibromyalgia found that the majority used CBD products to discontinue their use of NSAIDs, opioids, gabapentanoids & benzos. They saw improvements in health, pain, memory & sleep

Substituting Cannabidiol for Opioids and Pain Medications Among Individuals with Fibromyalgia: a Large Online Survey https://pubmed.ncbi.nlm.nih.gov/33992787/ In humans, this cohort analysis found that the diversity of your gut microbiome was related to your happiness & motivation via the endocannabinoid system, especially via PEA - which they call the endogenous version of CBD Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort https://pubmed.ncbi.nlm.nih.gov/34002020/

In the brain immune cells of mice, CBD causes anti-inflammatory & neuroprotective effects

Studies of involvement of G-protein coupled receptor-3 in cannabidiol effects on inflammatory responses of mouse primary astrocytes and microglia https://pubmed.ncbi.nlm.nih.gov/33984046/

In intestinal cells, CBD was their most promising compound against inflammation & oxidative stress

Cannabidiol Isolated From Cannabis sativa L. Protects Intestinal Barrier From In Vitro Inflammation and Oxidative Stress https://pubmed.ncbi.nlm.nih.gov/33995048/


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

This review looks at how involved the endocannabinoid system is in our hippocampus (a key memory & cognition area of the brain)

Cannabinoid control of hippocampal functions: the where matters https://pubmed.ncbi.nlm.nih.gov/33977665/

A review of CBD for mental health

Cannabidiol and mental health: possibilities, uncertainties, and controversies for addiction treatment https://pubmed.ncbi.nlm.nih.gov/34008796/

This review looks at the benefits of CBD for the eye

Cannabidiol Signaling in the Eye and Its Potential as an Ocular Therapeutic Agent https://pubmed.ncbi.nlm.nih.gov/33984199/

In this review of aggression, they find that activating the CB1 receptor helps suppress impulsive aggression

Regulation of stress-provoked aggressive behavior using endocannabinoids https://www.sciencedirect.com/science/article/pii/S235228952100045X

A review of cannabis & the skin

Cannabis and the Skin https://www.sciencedirect.com/science/article/abs/pii/S0738081X21000705

A review of cannabinoids for healthy hair

Topical and nutricosmetic products for healthy hair and dermal anti-aging using ‘dual-acting’ (2 for 1) plant-based peptides, hormones, and cannabinoids https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fba.2021-00022

Preclinical Research & Cannabinoid Chemistry

In mice, the ability of CBD to methylate DNA (deactivate it) may underlie some of its antipsychotic effects for schizophrenia

Cannabidiol prevents disruptions in sensorimotor gating induced by psychotomimetic drugs that last for 24-h with probable involvement of epigenetic changes in the ventral striatum https://pubmed.ncbi.nlm.nih.gov/34015384/

In a mouse model of pain, three of the main cannabis terpenes helped to reduce pain, possibly via the cannabinoid receptors

Evaluation of the Terpenes β-caryophyllene, α-terpineol, and γ-terpinene in the Mouse Chronic Constriction Injury Model of Neuropathic Pain: Possible Cannabinoid Receptor Involvement https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2021.35.S1.01643

In kidney cells, inhibiting the FAAH enzyme (an action of CBD) may be a treatment for chronic kidney disease

Inactivation of Endocannabinoid-metabolizing Enzyme FAAH Represses TGF-β1-induced Epithelial-mesenchymal Transition in Renal Proximal Tubular Epithelial Cells https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2021.35.S1.04342 Two hemp extracts from Chinese cultivars found to have potent antibiotic & antioxidant properties Antioxidant and antimicrobial activity of two standardized extracts from a new Chinese accession of non-psychotropic Cannabis sativa L https://pubmed.ncbi.nlm.nih.gov/33034400/

In ovarian cancer cells, full spectrum hemp extract found to have anticancer effects

Hemp Extract with Specific Anti-Cancer Properties against Ovarian Cancer https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2021.35.S1.02877


In rats, CBD made anesthesia work faster & made the effects last longer when they woke up

The Impact of Cannabidiol on the Induction of Isoflurane Anesthesia and Recovery in Wistar Rats https://pubmed.ncbi.nlm.nih.gov/33998903/

In animals addicted to meth, CBD worked via dopamine in the hippocampus to lessen the rewards & addictive nature of the drug

Involvement of Hippocampal D1-Like Dopamine Receptors in the Inhibitory Effect of Cannabidiol on Acquisition and Expression of Methamphetamine-Induced Conditioned Place Preference

https://pubmed.ncbi.nlm.nih.gov/33993443/

In mice addicted to alcohol, treatment with PSNCBAM-1 (a negative allosteric modulator of CB1, something that CBD also does) reduced ethanol taking behavior

The CB1 Negative Allosteric Modulator PSNCBAM-1 Reduces Ethanol Self-Administration via a Nonspecific Hypophagic Effect https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2021.35.S1.02929


In a mouse model of ALS, inactivating the CB2 receptor worsened the disease progression

Inactivation of the CB 2 receptor accelerated the neuropathological deterioration in TDP-43 transgenic mice, a model of amyotrophic lateral sclerosis https://pubmed.ncbi.nlm.nih.gov/33983653/

In brain slices from rats, persistent inflammation lowers the number of CB1 receptors in the rostral ventromedial medulla (a brain region related to pain signaling)

Persistent Inflammation Reduces Cannabinoid 1 Receptor Function in the Ventrolateral Periaqueductal Gray https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2021.35.S1.02474

In bone cells, this study looks at the interplay of endocannabinoids on the differentiation & remodeling of bones

Modulation of Endocannabinoid Tone in Osteoblastic Differentiation of MC3T3-E1 Cells and in Mouse Bone Tissue over Time https://www.mdpi.com/2073-4409/10/5/1199


In eye cells & in tadpoles, the CB1 receptors help enhance your vision & visual signaling

Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells https://pubmed.ncbi.nlm.nih.gov/27501334/

In mice infected with the parasite that causes toxoplasmosis, they saw an increased synthesis of CB1 & MAGL (the enzyme that created 2-AG)

Modulation of mRNA Expression of Monoacylglycerol Lipase, Diacylglycerol Lipase and Cannabinoid Receptor-1 in Mice Experimentally Infected with T. gondii http://ijmcmed.org/browse.php?a_id=1564&sid=1&slc_lang=en&ftxt=0 For more on this very weird disease & parasite, here's the great science communicator Dr. Robert Sapolsky.