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Research Roundup: Mar 5, 2024



Best of cannabinoid science this week...



In a double-blind study of patients with periodontitis (gum disease), CBD improved gingival bleeding & gingival scores as well as reducing inflammation in human gingival cells

Phytocannabinoids and gingival inflammation: Preclinical findings and a placebo-controlled double-blind randomized clinical trial with cannabidiol


In patients with plasma cell disorders such as the cancer myeloma, a survey found that they used cannabinoids for pain, sleep, depression & stress reduction

Cannabis and Cannabinoid Use and Perceptions in Patients with Plasma Cell Disorders: A National Healthtree Foundation for Multiple Myeloma Survey

In older adult cancer survivors, a survey found they used cannabis for pain & insomnia

Cannabis Perceptions and Patterns of Use Among Older Adult Cancer Survivors


For spasticity, 2 case reports of using cannabinoids [Portuguese]

USO DOS FITOCANABINÓIDES PARA TRATAMENTO DE ESPASTICIDADE MUSCULAR: RELATO DE CASO


In asthmatics, no association between cannabis use & an asthma attack

Asthma episode/attack risk by smoking status, self-reported gender, educational attainment, e-cigarette usage and exposure to marijuana smoke


In rotator cuff surgery patients, the use of CBD caused no deficits after a year of follow-up

Cannabidiol for Postoperative Pain Control After Arthroscopic Rotator Cuff Repair Demonstrates No Deficits in Patient-Reported Outcomes Versus Placebo: 1-Year Follow-up of a Randomized Controlled Trial


In cats, CBD seemed effective for easing separation anxiety

Is cannabidiol (CBD) effective to ease separation anxiety?

Also in canine blood immune cells, CBD or THC combined well with the commonly used dug dexamethasone & may be used to lower its dosage & side effects

Potential to use cannabinoids as adjunct therapy for dexamethasone: An in vitro study with canine peripheral blood mononuclear cells


For CBD, a review of the many mechanisms it uses for its therapeutic effects

A systematic review of molecular mechanism and therapeutic effect of Cannabidiol (CBD)


For head & neck conditions, CBD is suggested for obstructive sleep apnea, chronic pain, nausea & coughing

Cannabidiol (CBD): Potential Use in Otorhinolaryngology

In a rat model of obsessive-compulsive disorder resulting from epilepsy, CBD improved their symptoms in a gender-dependent manner

CBD treatment following early life seizures alters orbitofrontal-striatal signaling during adulthood

 

In a pig model of skin burns, a full spectrum cannabis oil with low THC & CBD decreased inflammation & reduced burn wound progression

Topical Noneuphoric Phytocannabinoid Elixir 14 Reduces Inflammation and Mitigates Burn Progression


In young rats, CBD lessened damage from brain hemorrhages via protection of the blood brain barrier & lowering of inflammation, excitotoxicity & oxidative stress

Cannabidiol reduces intraventricular hemorrhage brain damage, preserving myelination and preventing blood brain barrier dysfunction in immature rats


In a mouse model of bleeding around the brain, CBD lowered mortality rates & brain immune cell activation

Cannabidiol as a Therapy for Experimental Subarachnoid Hemorrhage


In a rat model of neuroinflammation from a high-fat diet, CBD lowered inflammation in the cerebral cortex via the reduction of lipid inflammation

Anti-inflammatory effects of cannabidiol in early stages of neuroinflammation induced by high-fat diet in cerebral cortex of rats


In a tissue model of food allergies, THC decreased the associated IgE antibodies

Inhibition of IgE production in Plasma Cell Line by Cannabinoid-Containing Product Associated with Regulation of XBP-1 and IgE heavy chain expression



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