top of page

Research Roundup: Mar 26, 2024

Best of cannabinoid science this week...

In 12 adults with multiple sclerosis, a nabiximol (1:1 THC:CBD spray) reduced spasticity, pain, sleep disorders, bladder dysfunction & improved walking distance

Effect of nabiximols oromucosal spray (Sativex®) on symptoms associated with multiple sclerosis-related spasticity: a case series

For chronic pain, a cohort study found overall long-term improvement from THC & CBD oils

Cannabis oil extracts for chronic pain: what else can be learned from another structured prospective cohort?

In a case study of someone with ADHD, tremors & irritable bowel syndrome, CBD improved all three conditions


In dogs with separation anxiety, two weeks of 2 mg CBD/kg /day led to significantly less vocalization during separations

Possible effects of cannabidiol (CBD) administration on the vocal activity of healthy domestic dogs upon their temporary separation from caregivers

Best practices for medical cannabis vaporization

Clinical Application of Cannabis Vaporization: Examining Safety and Best Practices

Cannabis & e-cigarette users more likely to be walking for exercise than non-users

The association between marijuana and e-cigarette use and exercise behavior among adults

In older Americans, 10% have now used cannabis in the last year & 80% hold a favorable attitude towards our favorite plant

Unrelenting Growth and Diversification: Using the Health and Retirement Study to Illuminate Cannabis Use among Aging Americans

In Pennsylvania patients, 90 days of observation saw significant improvements from medical cannabis

Observational Analysis of the Influence of Medical Marijuana Use on Quality of Life in Patients

“Of the 103 participants who completed the study, significant improvements were observed in physical and social functioning, emotional well-being, and energy levels within the first 30 days. Participants reported significant decreases in emotional limitations, fatigue, and pain levels.”

For pediatric patients, on removing barriers to access medical cannabis

Removing barriers to accessing medical cannabis for paediatric patients

A review of cannabinoids improving wound healing

The effect of cannabinoids on wound healing: A review

For the neurocognition problems of HIV (HAND), a chapter on the benefits of targeting the endocannabinoid system

Targeting the endocannabinoid system in HAND

A review on the potential of CBD for schizophrenia

Cannabidiol, cognition and schizophrenia: a narrative review

For Crohn's disease, a review of four studies on the use of cannabinoids finds moderate help

Effect of cannabinoids in mild-to-moderate cases of Crohn’s disease as compared to placebo: a systematic review and meta-analysis of randomised controlled trials

For lower back pain, a review of targeting the endocannabinoid system

Targeting the endocannabinoid system for the management of low back pain

A review on protection from neurodegeneration via the cannabinoid, Nrf2 (antioxidant) & ubiquitin (protein degradation) pathways (great chart)

Interactions Between the Ubiquitin-Proteasome System, Nrf2, and the Cannabinoidome as Protective Strategies to Combat Neurodegeneration: Review on Experimental Evidence

In a rat model of depression, seven days of CBD treatment changed synaptic plasticity & decreased symptoms of depression

Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression

In a rat model of a heart attack, CBD protected the brain against injury via its antioxidant, anti-inflammatory & anti-cellular death mechanisms

Investigation of neuroprotective and therapeutic effects of cannabidiol in an acute coronary syndrome model

In a mouse model of neuropathic pain, CBD reduced systemic pain via the activation of the PI3Kγ/nNOS/NO/KATP signaling pathway

Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation-dependent mechanism

In a mouse model of sleep deprivation leading to a heightened pain sensitivity, CBD significantly improved their thresholds for thermal & mechanical pain via dopamine receptors in the medium spiny neurons of the nucleus accumbens (neural interface between motivation & action)

Exploring the therapeutic potential of cannabidiol for sleep deprivation-induced hyperalgesia

In a rat model of lungs damaged by the cancer treatment methotrexate, CBD reduced many of the negatives

The effects of cannabidiol against Methotrexate-induced lung damage

In a tissue model of the muscle wasting caused by chemotherapy treatment, CBD protected from atrophy via the promotion of protein homeostasis & the reduction of oxidative stress

Cannabidiol protects C2C12 myotubes against cisplatin-induced atrophy by regulating oxidative stress

In human liver cells exposed to lead, CBD reduced the cellular uptake of lead & reversed the oxidative stress & inflammation it induced

Evaluation of the effect of cannabidiol on the THLE-2 liver cell line exposed to lead

In human skin cells, the ability of CBD to act as an antioxidant [Korean]

Antioxidant Activity of Cannabidiol (CBD) and Effect on Its Proliferation in Human Dermal Papilla Cells


bottom of page