Best of cannabinoid science this week...
In 12 adults with multiple sclerosis, a nabiximol (1:1 THC:CBD spray) reduced spasticity, pain, sleep disorders, bladder dysfunction & improved walking distance
Effect of nabiximols oromucosal spray (Sativex®) on symptoms associated with multiple sclerosis-related spasticity: a case series
For chronic pain, a cohort study found overall long-term improvement from THC & CBD oils
Cannabis oil extracts for chronic pain: what else can be learned from another structured prospective cohort?
In a case study of someone with ADHD, tremors & irritable bowel syndrome, CBD improved all three conditions
IMPROVEMENT OF IRRITABLE BOWEL SYNDROME AND ESSENTIAL TREMOR WITH CANNABIDIOL DESPITE USE OF METHYLPHENIDATE
In dogs with separation anxiety, two weeks of 2 mg CBD/kg /day led to significantly less vocalization during separations
Possible effects of cannabidiol (CBD) administration on the vocal activity of healthy domestic dogs upon their temporary separation from caregivers
Best practices for medical cannabis vaporization
Clinical Application of Cannabis Vaporization: Examining Safety and Best Practices
Cannabis & e-cigarette users more likely to be walking for exercise than non-users
The association between marijuana and e-cigarette use and exercise behavior among adults
In older Americans, 10% have now used cannabis in the last year & 80% hold a favorable attitude towards our favorite plant
Unrelenting Growth and Diversification: Using the Health and Retirement Study to Illuminate Cannabis Use among Aging Americans
In Pennsylvania patients, 90 days of observation saw significant improvements from medical cannabis
Observational Analysis of the Influence of Medical Marijuana Use on Quality of Life in Patients
“Of the 103 participants who completed the study, significant improvements were observed in physical and social functioning, emotional well-being, and energy levels within the first 30 days. Participants reported significant decreases in emotional limitations, fatigue, and pain levels.”
For pediatric patients, on removing barriers to access medical cannabis
Removing barriers to accessing medical cannabis for paediatric patients
A review of cannabinoids improving wound healing
The effect of cannabinoids on wound healing: A review
For the neurocognition problems of HIV (HAND), a chapter on the benefits of targeting the endocannabinoid system
Targeting the endocannabinoid system in HAND
A review on the potential of CBD for schizophrenia
Cannabidiol, cognition and schizophrenia: a narrative review
For Crohn's disease, a review of four studies on the use of cannabinoids finds moderate help
Effect of cannabinoids in mild-to-moderate cases of Crohn’s disease as compared to placebo: a systematic review and meta-analysis of randomised controlled trials
For lower back pain, a review of targeting the endocannabinoid system
Targeting the endocannabinoid system for the management of low back pain
A review on protection from neurodegeneration via the cannabinoid, Nrf2 (antioxidant) & ubiquitin (protein degradation) pathways (great chart)
Interactions Between the Ubiquitin-Proteasome System, Nrf2, and the Cannabinoidome as Protective Strategies to Combat Neurodegeneration: Review on Experimental Evidence
In a rat model of depression, seven days of CBD treatment changed synaptic plasticity & decreased symptoms of depression
Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression
In a rat model of a heart attack, CBD protected the brain against injury via its antioxidant, anti-inflammatory & anti-cellular death mechanisms
Investigation of neuroprotective and therapeutic effects of cannabidiol in an acute coronary syndrome model
In a mouse model of neuropathic pain, CBD reduced systemic pain via the activation of the PI3Kγ/nNOS/NO/KATP signaling pathway
Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation-dependent mechanism
In a mouse model of sleep deprivation leading to a heightened pain sensitivity, CBD significantly improved their thresholds for thermal & mechanical pain via dopamine receptors in the medium spiny neurons of the nucleus accumbens (neural interface between motivation & action)
Exploring the therapeutic potential of cannabidiol for sleep deprivation-induced hyperalgesia
In a rat model of lungs damaged by the cancer treatment methotrexate, CBD reduced many of the negatives
The effects of cannabidiol against Methotrexate-induced lung damage
In a tissue model of the muscle wasting caused by chemotherapy treatment, CBD protected from atrophy via the promotion of protein homeostasis & the reduction of oxidative stress
Cannabidiol protects C2C12 myotubes against cisplatin-induced atrophy by regulating oxidative stress
In human liver cells exposed to lead, CBD reduced the cellular uptake of lead & reversed the oxidative stress & inflammation it induced
Evaluation of the effect of cannabidiol on the THLE-2 liver cell line exposed to lead
In human skin cells, the ability of CBD to act as an antioxidant [Korean]
Antioxidant Activity of Cannabidiol (CBD) and Effect on Its Proliferation in Human Dermal Papilla Cells