Best of cannabinoid science this week...
In a survey of pediatric autism patients, the caregivers administered cannabis most frequently for repetitive behaviors & irritability & found high levels of CBD paired with low levels of THC tended to work best A natural history study of medical cannabis consumption in pediatric autism in the United States https://www.sciencedirect.com/science/article/abs/pii/S1750946722000812
A study of the effects of food on CBD absorption
Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Interaction with Food, and Influence on Liver Function
https://pubmed.ncbi.nlm.nih.gov/35631293
In a review of all the meta-analyses, people with psychosis who used cannabis showed “showed better neurocognitive performances … for planning/reasoning and working memory”, smaller effects for processing speed & attention & “Individuals with lifetime use appeared to show better neurocognitive functions”
The Potential Paradoxical Neurocognitive Effects of Cannabis Use in Patients with Psychotic Disorders: A Critical Meta-Review of Meta-Analytical Evidence
https://pubmed.ncbi.nlm.nih.gov/35666226
In humans with obesity, a CBDA analogue helped to improve metabolism, lose weight, reduce appetite, strengthen liver function & improved glycemic & lipid profiles The Metabolic Efficacy of a Cannabidiolic Acid (CBDA) Derivative in Treating Diet- and Genetic-Induced Obesity https://pubmed.ncbi.nlm.nih.gov/35628417
A cool review looks at how eating polyunsaturated fatty acids (PUFAs – the building blocks of endocannabinoids) affect how exercise alters your endocannabinoid system for neural plasticity & neural inflammation Dietary PUFA and Exercise Dynamic Actions on Endocannabinoids in Brain - Consequences for Neural Plasticity and Neuroinflammation https://pubmed.ncbi.nlm.nih.gov/35675221
In a model of endometriosis, CBD reduced lesions, caused antioxidant effects, lowered scar tissue formation, reduced inflammation & helped with pain Molecular and Biochemical Mechanism of Cannabidiol in the Management of the Inflammatory and Oxidative Processes Associated with Endometriosis https://pubmed.ncbi.nlm.nih.gov/35628240
A review of using CBD for chronic pain Analysing the perspectives of health professionals and legal cannabis users on the treatment of chronic pain with cannabidiol (CBD): A scoping review https://www.researchgate.net/publication/360972217_Analysing_the_perspectives_of_health_professionals_and_legal_cannabis_users_on_the_treatment_of_chronic_pain_with_cannabidiol_CBD_A_scoping_review
A review of using cannabis & CBD for treating animals: osteoarthritis, epilepsy aggressiveness Use of cannabis in the treatment of animals: a systematic review of randomized clinical trials https://pubmed.ncbi.nlm.nih.gov/35703023
In human sodium channels (which help control electrical signals in epilepsy), CBD-rich hemp extracts inhibited the channel at much lower doses than isolated CBD A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function https://pubmed.ncbi.nlm.nih.gov/35689251
In a mouse model of epilepsy, giving CBD extracts before inducing seizures caused the microglial cells (immune system guardians of the brain) to not move as much & not over accumulate in the hippocampus (memory center) causing a decrease in inflammation Prophylactic administration of cannabidiol reduces microglial inflammatory response to kainate-induced seizures and neurogenesis https://pubmed.ncbi.nlm.nih.gov/35700815
In a model of Alzheimer’s disease, CBD worked on the microglial (immune) cells to improve digestion of the amyloid-β plaques via the TRPV2 receptors as well as reducing neuroinflammation & improved functioning of the mitochondria (powerhouse of the cell) Cannabidiol Enhances Microglial Beta-Amyloid Peptide Phagocytosis and Clearance via Vanilloid Family Type 2 Channel Activation https://pubmed.ncbi.nlm.nih.gov/35628181
In microglial cells, treatment with CBD increased levels of the mitochondrial fusion protein Mitofusin 2 that deals with inflammation – and in mice, CBD lessened the anxiety response & cognitive deficits from an inflammatory challenge as well as helping in a mouse model of multiple sclerosis Mitofusin 2 confers the suppression of microglial activation by cannabidiol: Insights from in vitro and in vivo models https://pubmed.ncbi.nlm.nih.gov/35688339