top of page

Research Roundup: June 20, 2022

Best of cannabinoid science this week...

In a survey of pediatric autism patients, the caregivers administered cannabis most frequently for repetitive behaviors & irritability & found high levels of CBD paired with low levels of THC tended to work best A natural history study of medical cannabis consumption in pediatric autism in the United States

A study of the effects of food on CBD absorption Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Interaction with Food, and Influence on Liver Function

In a review of all the meta-analyses, people with psychosis who used cannabis showed “showed better neurocognitive performances … for planning/reasoning and working memory”, smaller effects for processing speed & attention & “Individuals with lifetime use appeared to show better neurocognitive functions” The Potential Paradoxical Neurocognitive Effects of Cannabis Use in Patients with Psychotic Disorders: A Critical Meta-Review of Meta-Analytical Evidence

In humans with obesity, a CBDA analogue helped to improve metabolism, lose weight, reduce appetite, strengthen liver function & improved glycemic & lipid profiles The Metabolic Efficacy of a Cannabidiolic Acid (CBDA) Derivative in Treating Diet- and Genetic-Induced Obesity

A cool review looks at how eating polyunsaturated fatty acids (PUFAs – the building blocks of endocannabinoids) affect how exercise alters your endocannabinoid system for neural plasticity & neural inflammation Dietary PUFA and Exercise Dynamic Actions on Endocannabinoids in Brain - Consequences for Neural Plasticity and Neuroinflammation

In a model of endometriosis, CBD reduced lesions, caused antioxidant effects, lowered scar tissue formation, reduced inflammation & helped with pain Molecular and Biochemical Mechanism of Cannabidiol in the Management of the Inflammatory and Oxidative Processes Associated with Endometriosis

A review of using CBD for chronic pain Analysing the perspectives of health professionals and legal cannabis users on the treatment of chronic pain with cannabidiol (CBD): A scoping review

A review of using cannabis & CBD for treating animals: osteoarthritis, epilepsy aggressiveness Use of cannabis in the treatment of animals: a systematic review of randomized clinical trials

In human sodium channels (which help control electrical signals in epilepsy), CBD-rich hemp extracts inhibited the channel at much lower doses than isolated CBD A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function

In a mouse model of epilepsy, giving CBD extracts before inducing seizures caused the microglial cells (immune system guardians of the brain) to not move as much & not over accumulate in the hippocampus (memory center) causing a decrease in inflammation Prophylactic administration of cannabidiol reduces microglial inflammatory response to kainate-induced seizures and neurogenesis

In a model of Alzheimer’s disease, CBD worked on the microglial (immune) cells to improve digestion of the amyloid-β plaques via the TRPV2 receptors as well as reducing neuroinflammation & improved functioning of the mitochondria (powerhouse of the cell) Cannabidiol Enhances Microglial Beta-Amyloid Peptide Phagocytosis and Clearance via Vanilloid Family Type 2 Channel Activation

In microglial cells, treatment with CBD increased levels of the mitochondrial fusion protein Mitofusin 2 that deals with inflammation – and in mice, CBD lessened the anxiety response & cognitive deficits from an inflammatory challenge as well as helping in a mouse model of multiple sclerosis Mitofusin 2 confers the suppression of microglial activation by cannabidiol: Insights from in vitro and in vivo models


bottom of page