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Research Roundup: June 18, 2024



Best of cannabinoid science this week...


In a 5-week study of CBD for blood pressure, the CBD lowered the body’s blood pressure while not causing any changes to brain blood flow

EFFECTS OF CHRONIC CANNABIDIOL DOSING ON BRAIN BLOOD FLOW: INSIGHTS FROM THE HYPER-H21-4 TRIAL

 

In people with osteoarthritis of the hand, a CBD transdermal gel three times a day for four weeks reduced pain ratings, increased grip strength & improved fatigue, stiffness & anxiety

An open-label feasibility trial of transdermal cannabidiol for hand osteoarthritis

 

A survey found that ~20% of pregnant people used CBD, most commonly for anxiety, depression, PTSD, pain, headache & nausea or vomiting

Cannabidiol-Only Product Use in Pregnancy in the United States and Canada: Findings From the International Cannabis Policy Study

 

In women with polycystic ovary syndrome, supplements of oleoylethanolamide significantly decreased glycemic status & inflammatory factors as well as a “remarkable” increase in total antioxidant capacity

Examining the oleoylethanolamide supplement effects on glycemic status, oxidative stress, inflammation, and anti-mullerian hormone in polycystic ovary syndrome

 

A case report of someone with KCNB1-related epilepsy responding to CBD

Continuous spike-wave of slow sleep in a patient with KCNB1-related epilepsy responsive to highly purified cannabidiol: a case report and comparison with literature

 

Preliminary data on CBD for familial hemiplegic migraine (migraine with aura & motor weakness)

Cannabidiol as a Potential Treatment for Familial Hemiplegic Migraines


For Alzheimer's disease, a review of the neuroprotective effects of the cannabinoids (in-depth chart)

A Comprehensive Exploration of the Multifaceted Neuroprotective Role of Cannabinoids in Alzheimer's Disease Across a Decade of Research

 

For postoperative pain, a review of using the cannabinoids

Use of cannabinoids for acute postoperative pain

 

For bariatric surgery, a review of the data on the effects of cannabis use on anesthetic considerations, weight loss, complications, mortality & psychiatric outcomes

Perioperative Cannabis Use in Bariatric Patients: A Review of Outcomes and Proposed Clinical Pathway for Management

 

For oral diseases, a review of using CBD

Cannabidiol and its application in the treatment of oral diseases: therapeutic potentials, routes of administration and prospects


For bacterial infections, a review of targeting the endocannabinoid system

Exploring the versatile roles of the endocannabinoid system and phytocannabinoids in modulating bacterial infections


In a rat model of Parkinson's disease, CBD improved memory & depression-like symptoms, lessened neuroinflammation & reduced the loss of dopamine-producing neurons

Cannabidiol improves nonmotor symptoms, attenuates neuroinflammation and favors hippocampal newborn neuronal maturation in a rat model of Parkinsonism

 

In a tissue model of multiple sclerosis, cannabis cultivars lowered neuroinflammation via the glial cells (guardian immune cells of the brain)

Selected cannabis cultivars modulate glial activation: in vitro and in vivo studies

 

In a mouse model of neuropathic pain from chemotherapy, the combination of CBD & CBG lowered mechanical sensitivity & behavioral signs of opioid withdrawal

Single and Combined Effects of Cannabigerol (CBG) and Cannabidiol (CBD) in Mouse Models of Oxaliplatin-Associated Mechanical Sensitivity, Opioid Antinociception, and Naloxone-Precipitated Opioid Withdrawal

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