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Research Roundup: June 18, 2024

Best of cannabinoid science this week...

In a 5-week study of CBD for blood pressure, the CBD lowered the body’s blood pressure while not causing any changes to brain blood flow



In people with osteoarthritis of the hand, a CBD transdermal gel three times a day for four weeks reduced pain ratings, increased grip strength & improved fatigue, stiffness & anxiety

An open-label feasibility trial of transdermal cannabidiol for hand osteoarthritis


A survey found that ~20% of pregnant people used CBD, most commonly for anxiety, depression, PTSD, pain, headache & nausea or vomiting

Cannabidiol-Only Product Use in Pregnancy in the United States and Canada: Findings From the International Cannabis Policy Study


In women with polycystic ovary syndrome, supplements of oleoylethanolamide significantly decreased glycemic status & inflammatory factors as well as a “remarkable” increase in total antioxidant capacity

Examining the oleoylethanolamide supplement effects on glycemic status, oxidative stress, inflammation, and anti-mullerian hormone in polycystic ovary syndrome


A case report of someone with KCNB1-related epilepsy responding to CBD

Continuous spike-wave of slow sleep in a patient with KCNB1-related epilepsy responsive to highly purified cannabidiol: a case report and comparison with literature


Preliminary data on CBD for familial hemiplegic migraine (migraine with aura & motor weakness)

Cannabidiol as a Potential Treatment for Familial Hemiplegic Migraines

For Alzheimer's disease, a review of the neuroprotective effects of the cannabinoids (in-depth chart)

A Comprehensive Exploration of the Multifaceted Neuroprotective Role of Cannabinoids in Alzheimer's Disease Across a Decade of Research


For postoperative pain, a review of using the cannabinoids

Use of cannabinoids for acute postoperative pain


For bariatric surgery, a review of the data on the effects of cannabis use on anesthetic considerations, weight loss, complications, mortality & psychiatric outcomes

Perioperative Cannabis Use in Bariatric Patients: A Review of Outcomes and Proposed Clinical Pathway for Management


For oral diseases, a review of using CBD

Cannabidiol and its application in the treatment of oral diseases: therapeutic potentials, routes of administration and prospects

For bacterial infections, a review of targeting the endocannabinoid system

Exploring the versatile roles of the endocannabinoid system and phytocannabinoids in modulating bacterial infections

In a rat model of Parkinson's disease, CBD improved memory & depression-like symptoms, lessened neuroinflammation & reduced the loss of dopamine-producing neurons

Cannabidiol improves nonmotor symptoms, attenuates neuroinflammation and favors hippocampal newborn neuronal maturation in a rat model of Parkinsonism


In a tissue model of multiple sclerosis, cannabis cultivars lowered neuroinflammation via the glial cells (guardian immune cells of the brain)

Selected cannabis cultivars modulate glial activation: in vitro and in vivo studies


In a mouse model of neuropathic pain from chemotherapy, the combination of CBD & CBG lowered mechanical sensitivity & behavioral signs of opioid withdrawal

Single and Combined Effects of Cannabigerol (CBG) and Cannabidiol (CBD) in Mouse Models of Oxaliplatin-Associated Mechanical Sensitivity, Opioid Antinociception, and Naloxone-Precipitated Opioid Withdrawal


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