Best of cannabinoid science this week...
In a double-blind trial of people living with dementia, a 3:2 THC:CBD medicine was safe & well tolerated with a decrease in agitation & an increase in sleep Examining the use of cannabidiol and delta-9-tetrahydrocannabinol-based medicine among individuals diagnosed with dementia living within residential aged care facilities: Results of a double-blind randomised crossover trial https://pubmed.ncbi.nlm.nih.gov/37321847/
For athletes, a review about how CBD maybe helping via the microRNA (regulators of gene expression)
Major aspects of cannabidiol in the interaction with microRNAs and exosomes in the modulation of inflammatory and immunological processes in athletes: a systematic review
A review of depression & its relation to the endocannabinoid system as well as potential treatments POSSIBLE EFFECTS OF THE ENDOCANNABINOID SYSTEM ON THE PATHOPHYSIOLOGY OF DEPRESSION: MEDICAL TREATMENT APPROACHES BASED ON THIS SYSTEM https://cms.turkmedstudj.com/Uploads/Article_60707/tmsj-10-86-En.pdf
A review on treating Parkinson's disease by using cannabinoids on the inflammasome NLRP3 pathway
Neuromodulation in Parkinson's disease targeting opioid and cannabinoid receptors, understanding the role of NLRP3 pathway: a novel therapeutic approach
In rats, the oral bioavailability of CBD was superior when coming from a full spectrum product versus isolate or broad spectrum Comparative Pharmacokinetics of Commercially Available Cannabidiol Isolate, Broad-Spectrum, and Full-Spectrum Products https://pubmed.ncbi.nlm.nih.gov/37337087/
A solid review on the use of CBD in dogs Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge https://pubmed.ncbi.nlm.nih.gov/37456953/
In rats, the anti-inflammatory effects of oral CBD were stronger than the anti-inflammatory drug diclofenac (an NSAID sold under the brand name Voltaren) Anti-inflammatory effects of oral cannabidiol in rat models https://f1000research.com/articles/12-680
In older mice, microdoses of THC caused remarkable long lasting improvements in cognitive functions, especially in the hippocampus (memory center) Hippocampal differential expression underlying the neuroprotective effect of delta-9-tetrahydrocannabinol microdose on old mice https://www.frontiersin.org/articles/10.3389/fnins.2023.1182932/full
Thesis project of the week: in a mouse model of social anxiety, CBD vapor improved their social interactions Cannabidiol Administered via Vapor Inhalation Restores Social Interaction Deficits in a Mouse Model of Social Anxiety https://cedar.wwu.edu/cgi/viewcontent.cgi?article=2221&context=wwuet
In a rat model of endotoxemia (dead bacteria causing toxic inflammatory effects), THC protected the heart from inflammatory stress Delta 9-tetrahydrocannabinol conserves cardiovascular functions in a rat model of endotoxemia: Involvement of endothelial molecular mechanisms and oxidative-nitrative stress https://pubmed.ncbi.nlm.nih.gov/37327228/
In a zebrafish model of neurotoxicity from aluminum, CBD & THC oils activated the chlorogenic nervous system for neuroprotection resulting in positive behavioral biomarker changes Cannabis sativa-based oils against aluminum-induced neurotoxicity https://pubmed.ncbi.nlm.nih.gov/37330587/
A binding study of how CBD is inhibiting sodium channels (important for brain health & neuronal excitability) Cannabidiol inhibits Nav channels through two distinct binding sites https://pubmed.ncbi.nlm.nih.gov/37330538/
A hemopressin peptide that promotes NREM sleep works via the CB1 receptor An α-hemoglobin-derived peptide (m)VD-hemopressin (α) promotes NREM sleep via the CB1 cannabinoid receptor https://pubmed.ncbi.nlm.nih.gov/37456761/