Best of cannabinoid science this week...
In patients with chronic pain & chronic cancer pain, a survey found that cannabis lowered their pain levels as well as improved appetite, anxiety & enjoyment of life, with only the common side effects of dry mouth, drowsiness & headache
Prevalence and Characteristics of Medicinal Cannabis Use among Chronic Pain Patients; A Post- Legalization Study in a Tertiary Care Setting in Thailand
In people using commercially available cannabis during aerobic exercise, they reported more positive affect, enjoyment & runners high symptoms as well as more exertion
Acute Effects of Ad Libitum Use of Commercially Available Cannabis Products on the Subjective Experience of Aerobic Exercise: A Crossover Study
In a survey of German patients on their CBD usage, the primary reason was for pain as well as improved spasticity & well-being
Patients' perspectives on prescription cannabinoid therapies: a cross-sectional, exploratory, anonymous, one-time web-based survey among German patients
“Most participants experienced their therapy with cannabinoids as more effective than their previous therapy… Effect sizes observed for pain reduction, quality of life, social participation, and other outcomes suggest a therapeutic potential, particularly in the treatment of chronic pain.”
On the cost efficacy of treating rare seizure disorders with CBD
Cost-Effectiveness of Cannabidiol (CBD) for the Treatment of Seizures in Patients with Treatment-Resistant Lennox-Gastaut Syndrome or Dravet Syndrome in the Netherlands
A large twins study found few persistent effects on mental health from lifetime exposure to cannabis except for small increases in cannabis use disorder, tobacco frequency & illicit drug use
Limited psychological and social effects of lifetime cannabis use frequency: Evidence from a 30-year community study of 4,078 twins
In patients with inflammatory bowel disorder, six months of medical cannabis increased their appetite
Medical Cannabis Increases Appetite but Not Body Weight in Patients with Inflammatory Bowel Diseases
In Alzheimer's disease, a review of how the cannabinoid receptors interact with the microglia (guardian immune cells of the brain)
The Interplay between Cannabinoid Receptors and Microglia in the Pathophysiology of Alzheimer's Disease
And a review of cannabinoids for brain diseases like epilepsy & Alzheimer's
Comprehensive review of cannabis including cannabinoid brain function
For Alzheimer's disease, an analysis of how CBD prevented & alleviated the neurodegeneration
Assessing Cannabidiol as a Therapeutic Agent for Preventing and Alleviating Alzheimer's Disease Neurodegeneration
A preclinical study on the bioactive compounds in cannabis oil that lower neuroinflammation of Alzheimer’s via the microglia
Identification of Anti-Neuroinflammatory Bioactive Compounds in Essential Oils and Aqueous Distillation Residues Obtained from Commercial Varieties of Cannabis sativa L
A review of the biochemical evidence on why it makes sense to use cannabinoids for Alzheimer's disease
Potential Therapeutic Role of Cannabinoid System in Alzheimer’s Disease: A Review
For Parkinson's disease, a review of targeting the CB2 receptor
Research progress on the cannabinoid type-2 receptor and Parkinson's disease
A review of the potential of cannabinoids for GI tract diseases, especially via activation of the CB2 receptor
Cannabinoids and the Gastrointestinal Tract
In stroke recovery, the importance of the CB1 & CB2 receptors for neuroprotection
Neuroprotection and Beyond: The Central Role of CB1 and CB2 Receptors in Stroke Recovery
For neuropathic pain, an overview of clinical trials from the last 10 years
Phytocannabinoids for the Treatment of Neuropathic Pain: A Scoping Review of Randomised Controlled Trials Published Between 2012 and 2023
For inflammation, a review of 30k+ studies found anti-inflammatory effects from cannabis roots, stems, bark & leaf
Experimental Studies on the Anti-inflammatory Effect of Cannabis sativa based on a Scientometric Analysis
In rats with neuroinflammation, CBD improved their memory & decreased inflammatory cytokines
Cannabidiol improves memory and decreases IL-1β serum levels in rats with lipopolysaccharide-induced inflammation
In a rat model of traumatic brain injury, CBD caused anticonvulsant effects
Anticonvulsant effect of cannabidiol after lateral fluid percussion brain injury in rats
In rodents, cannabis increased appetite by targeting the hypothalamus (brain center of homeostasis) via the CB1 receptors
Cannabis Sativa targets mediobasal hypothalamic neurons to stimulate appetite
In a rat model of diabetes, when blood flows stopped to the heart, THC pretreatment reduced oxidative stress & the size of the dead area as well as improving cardiac function
Impacts of delta 9-tetrahydrocannabinol against myocardial ischemia/reperfusion injury in diabetic rats: Role of PTEN/PI3K/Akt signaling pathway
In mice, the ability of CBC to lower pain
Antinociceptive Effects of Cannabichromene (CBC) in Mice: Insights from von Frey, Tail-Flick, Formalin, and Acetone Tests
The anti-inflammatory potential of CBC
In Vitro and In Vivo Anti-Inflammatory Potential of Cannabichromene Isolated from Hemp