Best of the Week...
This observational study looks at 20 patients using a combination of melatonin & CBD extracts for insomnia
Insomnia treatment: a new multitasking natural compound based on melatonin and cannabis extracts
This review looks at CBD for inflammation & autoimmune disorders
Efficacy of utilizing cannabidiol in reduction of inflammation and autoimmunity manifestation
An analysis of the patients in the UK’s Medical Cannabis Registry, they found “treatment to be associated with a relatively low incidence of severe adverse events” & “positive changes following treatment were observed in general, as well as anxiety and sleep-specific, HRQoL [health-related quality of life] outcomes”
An Updated Analysis of Clinical Outcome Measures Across Patients From the UK Medical Cannabis Registry
Jazz Pharmaceuticals started enrolling patients in their PTSD clinical trial for JZP150 – a FAAH inhibitor
Jazz Pharmaceuticals Announces First Patient Enrolled in Phase 2 Clinical Trial Evaluating JZP150 for Once-Daily Treatment of Adults with Post-Traumatic Stress Disorder
Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)
In brain wave scans of pediatric epilepsy patients, the use of CBD saw 70% improve in their EEGs
Electroencephalographic changes in purified pharmaceutical cannabidiol therapy
A study of anxiety in humans finds that 2-AG levels change in response to stress
Endocannabinoid system reactivity during stress processing in healthy humans
A survey finds that cannabis helped with sleep quality
Cannabis Use and Sleep Quality in Daily Life: a Daily Diary Study of Adults Starting Cannabis for Health Concerns
In humans with osteoarthritis, the use of medical cannabis reduced prescriptions for opioids
Medical Cannabis Use Reduces Opioid Prescriptions in Patients With Osteoarthritis
In humans with blepharospasm (uncontrolled blinking or eyelid twitching), medical cannabis oil was a safe & effective treatment
Medical cannabis oil for benign essential blepharospasm: a prospective, randomized controlled pilot study
This editorial suggests blocking the CB1 receptor for the treatment of cholangitis (inflammation of the bile duct)
Cannabinoid Receptor 1 Antagonism Demonstrates High Therapeutic Potential for the Treatment of Primary Sclerosing Cholangitis
Recent Reviews
This review of the literature suggests that the combination of spinal cord stimulation & cannabinoids work for chronic pain
Dorsal Column Stimulation and Cannabinoids in the Treatment of Chronic Nociceptive and Neuropathic Pain: a Review of the Clinical and Pre-clinical Data
A review of the therapeutic use of the cannabinoids
Cannabinoids As A Potential Therapeutic Agent: A Comprehensive Review
A review of pharmaceutical versions of THC find them to be safe & with just the usual side effects of dizziness, drowsiness & dry mouth
The Safety of Dronabinol and Nabilone: A Systematic Review and Meta-Analysis of Clinical Trials
Technically, dronabinol is a synthetic form of THC while nabilone is a mimic of THC.
A review on how the Mediterranean diet improves the endocannabinoid system
The Mediterranean Diet as a Source of Bioactive Molecules with Cannabinomimetic Activity in Prevention and Therapy Strategy
A review of CBG
Cannabigerol: a bibliometric overview and review of research on an important phytocannabinoid
A review of the challenging biotechnology around cannabis biochemistry
Evolution, genetics and biochemistry of plant cannabinoid synthesis: a challenge for biotechnology in the years ahead
Preclinical Research & Cannabinoid Chemistry
In a worm model of Alzheimer’s, CBD prevented disease progression via the scavenging of reactive oxygen species
Cannabidiol protects against Alzheimer's disease in C. elegans via ROS scavenging activity of its phenolic hydroxyl groups
A study of what effects the absorption of CBD into human skin
In vitro percutaneous absorption studies of cannabidiol using human skin: Exploring the effect of drug concentration, chemical enhancers, and essential oils
In a rat model of epilepsy, allosteric modulators of the CB1 receptor reduced seizures & spike-and-wave discharges in the brain
The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg
In a mouse model of pain, the ability of a black pepper extract seemed to control pain via the CB2 receptor, a PPAR nuclear receptor that controls genetic transcription & the TRPV1 vanilloid receptor
Viphyllin TM, a Standardized Black Pepper Seed Extract Exerts Antinociceptive Effects in Murine Pain Models via Activation of Cannabinoid Receptor CB2, Peroxisome Proliferator-Activated Receptor-Alpha and TRPV1 Ion Channels
For osteoporosis, several types of tests show the efficacy of targeting the CB2 receptor
Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects
In a rat model of Parkinson’s, this research looks at how the endocannabinoidome is altered by the α-synuclein of the disease
Time-Course of Alterations in the Endocannabinoid System after Viral-Mediated Overexpression of α-Synuclein in the Rat Brain
In rats addicted to cocaine, they saw alterations in the CB1 receptors of their hippocampus (memory area of the brain)
Hippocampal Cannabinoid 1 Receptors Are Modulated Following Cocaine Self-administration in Male Rats
In a comparison of specialized white blood cells in mice & humans, they process endocannabinoids differently
Human and Mouse Eosinophils Differ in Their Ability to Biosynthesize Eicosanoids, Docosanoids, the Endocannabinoid 2-Arachidonoyl-glycerol and Its Congeners
This team was curious why a treatment for asthma that worked in mice did not work as well in humans. Well, it turns out that we’re not always the same.
It’s always a tough problem in research. Even something as highly conserved as the endocannabinoid system – which far predates the existence of mammals – there’s still differences between us & our other friends with spinal cords.
In aging rats, researchers look at the levels of CB1 receptors & the altered binding as they age
Age-related changes in CB1 receptor expression and function and the behavioral effects of cannabinoid receptor ligands
A version of CBG produced in yeast is a helpful anti-inflammatory for the skin
In Vitro and Clinical Evaluation of Cannabigerol (CBG) Produced via Yeast Biosynthesis: A Cannabinoid with a Broad Range of Anti-Inflammatory and Skin Health-Boosting Properties
A new synthetic cannabinoid is created that activates the CB2 receptor, crosses the blood-brain barrier & is orally bioavailable
Identification of an Orally Bioavailable, Brain-Penetrant Compound with Selectivity for the Cannabinoid Type 2 Receptor