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Research Roundup: Feb 28, 2022




Best of the Week...


This observational study looks at 20 patients using a combination of melatonin & CBD extracts for insomnia

Insomnia treatment: a new multitasking natural compound based on melatonin and cannabis extracts

https://pubmed.ncbi.nlm.nih.gov/35147654/

This review looks at CBD for inflammation & autoimmune disorders

Efficacy of utilizing cannabidiol in reduction of inflammation and autoimmunity manifestation

https://www.researchgate.net/publication/358517813_Efficacy_of_utilizing_cannabidiol_in_reduction_of_inflammation_and_autoimmunity_manifestation

An analysis of the patients in the UK’s Medical Cannabis Registry, they found “treatment to be associated with a relatively low incidence of severe adverse events” & “positive changes following treatment were observed in general, as well as anxiety and sleep-specific, HRQoL [health-related quality of life] outcomes”

An Updated Analysis of Clinical Outcome Measures Across Patients From the UK Medical Cannabis Registry

https://pubmed.ncbi.nlm.nih.gov/35073160/

Jazz Pharmaceuticals started enrolling patients in their PTSD clinical trial for JZP150 – a FAAH inhibitor

Jazz Pharmaceuticals Announces First Patient Enrolled in Phase 2 Clinical Trial Evaluating JZP150 for Once-Daily Treatment of Adults with Post-Traumatic Stress Disorder

https://www.finanzen.net/nachricht/aktien/jazz-pharmaceuticals-announces-first-patient-enrolled-in-phase-2-clinical-trial-evaluating-jzp150-for-once-daily-treatment-of-adults-with-post-traumatic-stress-disorder-10884115

Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)

In brain wave scans of pediatric epilepsy patients, the use of CBD saw 70% improve in their EEGs

Electroencephalographic changes in purified pharmaceutical cannabidiol therapy

https://pubmed.ncbi.nlm.nih.gov/35078115/

A study of anxiety in humans finds that 2-AG levels change in response to stress

Endocannabinoid system reactivity during stress processing in healthy humans

https://pubmed.ncbi.nlm.nih.gov/35090896/

A survey finds that cannabis helped with sleep quality

Cannabis Use and Sleep Quality in Daily Life: a Daily Diary Study of Adults Starting Cannabis for Health Concerns

https://www.medrxiv.org/content/10.1101/2022.01.19.22269565v2.full.pdf

In humans with osteoarthritis, the use of medical cannabis reduced prescriptions for opioids

Medical Cannabis Use Reduces Opioid Prescriptions in Patients With Osteoarthritis

https://www.cureus.com/articles/83416-medical-cannabis-use-reduces-opioid-prescriptions-in-patients-with-osteoarthritis

In humans with blepharospasm (uncontrolled blinking or eyelid twitching), medical cannabis oil was a safe & effective treatment

Medical cannabis oil for benign essential blepharospasm: a prospective, randomized controlled pilot study

https://pubmed.ncbi.nlm.nih.gov/35067772/

This editorial suggests blocking the CB1 receptor for the treatment of cholangitis (inflammation of the bile duct)

Cannabinoid Receptor 1 Antagonism Demonstrates High Therapeutic Potential for the Treatment of Primary Sclerosing Cholangitis

https://pubmed.ncbi.nlm.nih.gov/35131175/



Recent Reviews


This review of the literature suggests that the combination of spinal cord stimulation & cannabinoids work for chronic pain

Dorsal Column Stimulation and Cannabinoids in the Treatment of Chronic Nociceptive and Neuropathic Pain: a Review of the Clinical and Pre-clinical Data

https://pubmed.ncbi.nlm.nih.gov/35119602/

A review of the therapeutic use of the cannabinoids

Cannabinoids As A Potential Therapeutic Agent: A Comprehensive Review

https://www.nveo.org/index.php/journal/article/view/4105

A review of pharmaceutical versions of THC find them to be safe & with just the usual side effects of dizziness, drowsiness & dry mouth

The Safety of Dronabinol and Nabilone: A Systematic Review and Meta-Analysis of Clinical Trials

https://pubmed.ncbi.nlm.nih.gov/35056154/

Technically, dronabinol is a synthetic form of THC while nabilone is a mimic of THC.

A review on how the Mediterranean diet improves the endocannabinoid system

The Mediterranean Diet as a Source of Bioactive Molecules with Cannabinomimetic Activity in Prevention and Therapy Strategy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839035/

A review of CBG

Cannabigerol: a bibliometric overview and review of research on an important phytocannabinoid

https://link.springer.com/article/10.1007/s11101-021-09794-w

A review of the challenging biotechnology around cannabis biochemistry

Evolution, genetics and biochemistry of plant cannabinoid synthesis: a challenge for biotechnology in the years ahead

https://pubmed.ncbi.nlm.nih.gov/35085909/



Preclinical Research & Cannabinoid Chemistry


In a worm model of Alzheimer’s, CBD prevented disease progression via the scavenging of reactive oxygen species

Cannabidiol protects against Alzheimer's disease in C. elegans via ROS scavenging activity of its phenolic hydroxyl groups

https://pubmed.ncbi.nlm.nih.gov/35181336/

A study of what effects the absorption of CBD into human skin

In vitro percutaneous absorption studies of cannabidiol using human skin: Exploring the effect of drug concentration, chemical enhancers, and essential oils

https://pubmed.ncbi.nlm.nih.gov/35124116/

In a rat model of epilepsy, allosteric modulators of the CB1 receptor reduced seizures & spike-and-wave discharges in the brain

The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

https://pubmed.ncbi.nlm.nih.gov/35128516/

In a mouse model of pain, the ability of a black pepper extract seemed to control pain via the CB2 receptor, a PPAR nuclear receptor that controls genetic transcription & the TRPV1 vanilloid receptor

Viphyllin TM, a Standardized Black Pepper Seed Extract Exerts Antinociceptive Effects in Murine Pain Models via Activation of Cannabinoid Receptor CB2, Peroxisome Proliferator-Activated Receptor-Alpha and TRPV1 Ion Channels

https://pubmed.ncbi.nlm.nih.gov/35153513/

For osteoporosis, several types of tests show the efficacy of targeting the CB2 receptor

Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects

https://pubmed.ncbi.nlm.nih.gov/35163968/

In a rat model of Parkinson’s, this research looks at how the endocannabinoidome is altered by the α-synuclein of the disease

Time-Course of Alterations in the Endocannabinoid System after Viral-Mediated Overexpression of α-Synuclein in the Rat Brain

https://pubmed.ncbi.nlm.nih.gov/35056822/

In rats addicted to cocaine, they saw alterations in the CB1 receptors of their hippocampus (memory area of the brain)

Hippocampal Cannabinoid 1 Receptors Are Modulated Following Cocaine Self-administration in Male Rats

https://pubmed.ncbi.nlm.nih.gov/35032317/

In a comparison of specialized white blood cells in mice & humans, they process endocannabinoids differently

Human and Mouse Eosinophils Differ in Their Ability to Biosynthesize Eicosanoids, Docosanoids, the Endocannabinoid 2-Arachidonoyl-glycerol and Its Congeners

https://pubmed.ncbi.nlm.nih.gov/35011703/

This team was curious why a treatment for asthma that worked in mice did not work as well in humans. Well, it turns out that we’re not always the same.

It’s always a tough problem in research. Even something as highly conserved as the endocannabinoid system – which far predates the existence of mammals – there’s still differences between us & our other friends with spinal cords.

In aging rats, researchers look at the levels of CB1 receptors & the altered binding as they age

Age-related changes in CB1 receptor expression and function and the behavioral effects of cannabinoid receptor ligands

https://pubmed.ncbi.nlm.nih.gov/35077729/

A version of CBG produced in yeast is a helpful anti-inflammatory for the skin

In Vitro and Clinical Evaluation of Cannabigerol (CBG) Produced via Yeast Biosynthesis: A Cannabinoid with a Broad Range of Anti-Inflammatory and Skin Health-Boosting Properties

https://pubmed.ncbi.nlm.nih.gov/35056807/

A new synthetic cannabinoid is created that activates the CB2 receptor, crosses the blood-brain barrier & is orally bioavailable

Identification of an Orally Bioavailable, Brain-Penetrant Compound with Selectivity for the Cannabinoid Type 2 Receptor

https://pubmed.ncbi.nlm.nih.gov/35056824/