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Research Roundup: Feb 20, 2024



Best of cannabinoid science this week...


In humans with anxiety, CBD-rich cannabis reduced acute tension while the THC-rich cannabis did not increase anxiety

Acute and Extended Anxiolytic Effects of Cannabidiol in Cannabis Flower: A Quasi-Experimental ad libitum Use Study


In children with autism, four weeks of treatment with a low-THC full-spectrum extract caused significant overall improvements in symptoms

Safety and efficacy of orally administered full-spectrum medicinal cannabis plant extract 0.08% THC (NTI-164) in children with autism spectrum disorder: An open-label study


In a survey of people with arthritic joint pain, CBD caused high rates of symptomatic relief & reductions in pharmacological treatments (opioids, acetaminophen & anti-inflammatories)

An Exploratory Cross-Sectional Analysis of Cannabidiol use for Arthritic Joint Pain


In men with HIV on antiretroviral therapy, cannabis use was associated with reduced viral loads & reduced inflammation

Cannabis Use Associates With Reduced Proviral Burden and Inflammatory Cytokine in Tissues From Men With Clade C HIV-1 on Suppressive Antiretroviral Therapy

And in people living with HIV, CBD treatment is associated with the expression of anti-inflammatory genes

Oral Cannabidiol Treatment Is Associated with an Anti-Inflammatory Gene Expression Signature in Myeloid Cells of People Living with HIV


In people with strokes, a combination of PEA & luteolin (a flavonoid commonly paired with PEA) for 90 days improved their neurological scores & cognitive function

PEALut in the Dietary Management of Patients with Acute Ischemic Stroke: A Prospective Randomized Controlled Clinical Trial


A case report of using CBD to treat a type of epilepsy associated with the SYNGAP1 mutation

Epileptic and neurodevelopmental encephalopathy associated to SYNGAP1 mutation: Description of a case and treatment response to cannabidiol


In dogs exposed to the stress of repeated car travel, CBD lowered their cortisol, whining, lip licking & measures of stressful behaviors

Daily dosing of cannabidiol (CBD) demonstrates a positive effect on measures of stress in dogs during repeated exposure to car travel


A case study of reducing the harms from alcohol & other drugs by donating cannabis to people

Cannabis donation as a harm reduction strategy: A case study


For acne, the potential of the cannabinoids

Treatment Advances for Acne Vulgaris: The Scientific Role of Cannabinoids


A review on how the benefits of acupuncture may be mediated via the endocannabinoid receptors

Advances in the study of endocannabinoid receptors in experimental acupuncture analgesia


A nice review of the many pathways used by CBD (cool charts)

An Overview of Cannabidiol as a Multifunctional Drug: Pharmacokinetics and Cellular Effects

And a review of 68 studies on the many aspects of CBD

Pharmacological and morphological features and socioeconomic aspects of cannabidiol: A literature review


For autism, a review of using the cannabinoids

Cannabinoid treatment for the symptoms of autism spectrum disorder


For Alzheimer's disease & aging, a review of CBD treatment

Alzheimer's disease, aging, and cannabidiol treatment: a promising path to promote brain health and delay aging

And a case report & literature review of CBD for neuromotor disorders [Portuguese]

The impact of cannabidiol on neuromotor disorders: a case report and literature review


For treating psychosomatic disorders (characterized by activation of the HPA axis), a review on targeting the endocannabinoid system

The endocannabinoid system: A new frontier in addressing psychosomatic challenges


For chronic pain, a review of using cannabinoids as well as alternative therapies

The use of cannabinoids and alternative therapies in chronic pain management: a narrative review

And a review on using CBD for chronic pain conditions involving the trigeminal nerve

Trigeminal Neuralgia and Cannabidiol Approach


Against corona & influenza viruses, CBD & the terpenes caused anti-inflammatory & antiviral activity

Terpenes and cannabidiol against human corona and influenza viruses-Anti-inflammatory and antiviral in vitro evaluation


For the bacteria of tuberculosis, the antibacterial effects of CBD

Antimicrobial Effect of Cannabidiol on Intracellular Mycobacterium tuberculosis


In a mouse model of multiple sclerosis, CBD decreased biomarkers associated with neuroinflammation via the reduction of M1 polarization & decreased TNF-α secretion

The mechanism by which cannabidiol (CBD) suppresses TNF-α secretion involves inappropriate localization of TNF-α converting enzyme (TACE)


In a rat model of sepsis, CBD protected from cognitive impairment, restored brain growth factor BDNF & reduced neuroinflammation & oxidative stress via the PPAR nuclear receptors (that control genetic transcription)

Cannabidiol effect on long-term brain alterations in septic rats: Involvement of PPARγ activation


In a mouse model of colitis, nano-CBD protected the colon from damage, improved the gut microbiome & restored the intestinal mucosal barrier function & intestinal mucosal permeability

Multi-targeting inulin-based nanoparticles with cannabidiol for effective prevention of ulcerative colitis


A study in piglets finds that intravenous CBD is rapidly distributed to the peripheral tissue & slowly released into the bloodstream

An Intravenous Pharmacokinetic Study of Cannabidiol Solutions in Piglets through the Application of a Validated Ultra-High-Pressure Liquid Chromatography Coupled to Tandem Mass Spectrometry Method for the Simultaneous Quantification of CBD and Its Carboxylated Metabolite in Plasma

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