Best of cannabinoid science this week...
In people with treatment resistant epilepsy, CBD lowered their brain temperature levels as well as their seizure severity
The longitudinal effects of cannabidiol on brain temperature in patients with treatment-resistant epilepsy
And in infants with epileptic spasms, CBD caused a more than 50% reduction with good tolerability
Purified cannabidiol as add-on therapy in children with treatment-resistant infantile epileptic spasms syndrome
A meta-analysis of PTSD studies found cannabis use associated with significant improvements
Cannabis use and trauma-focused treatment for co-occurring posttraumatic stress disorder and substance use disorders: A meta-analysis of individual patient data
In humans, topical CBD reached its peak blood concentration after 7 to 10 days of product use (with no positive urine tests, but some positive oral fluid tests)
Pharmacokinetics and Pharmacodynamics of Five Distinct Commercially Available Hemp-derived Topical Cannabidiol (CBD) Products
In public health data about heart failure hospitalizations, cannabis use was associated with decreased mortality & length of stay
Cannabis Use Is Associated With Decreased Mortality And Length Of Stay In Heart Failure Hospitalizations
Cannabis use is growing among adult MS patients with chronic pain
Growing cannabis use among Multiple Sclerosis adults with chronic pain; An analysis from the United States
A review on the neurotherapeutic arsenal of cannabis
The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effects
For ALS, a review of the dysregulated endocannabinoid system as a therapeutic target
Dysregulated expanded endocannabinoid system as therapeutic targets of amyotrophic lateral sclerosis
A meta-analysis of 10 studies of people with opioid use disorder, there is no association between their cannabis use & non-medical opioid use
The impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies
A review of your food intake regulation system & the role of the CB2 receptor
Role of the CB2 Cannabinoid Receptor in the Regulation of Food Intake: A Systematic Review
A review of the ECS & your glymphatic system (a recently discovered waste clearance system of the brain)
Interplay between the Glymphatic System and the Endocannabinoid System: Implications for Brain Health and Disease
In a mouse model of heart failure, CBD was protective via anti-inflammatory effects
Cannabidiol As A Potential Treatment For Heart Failure With Preserved Ejection Fraction
In a mouse model of osteoarthritis, CBD oil & CBG oil lowered pain & inflammation & helped to protect their local motor activity while the CBG oil reduced cartilage degeneration
Therapeutic Effects of Non-Euphorigenic Cannabis Extracts in Osteoarthritis
In a rat model of lung scarring, CBD reduced the symptoms via the gut microbiome
Integrating fecal metabolomics and intestinal microbiota to study the mechanism of cannabidiol in the treatment of idiopathic pulmonary fibrosis
In brain cells, a CBD rich extract caused anti-inflammatory & neuroprotective effects
Evaluation of the efficacy of a full-spectrum medicinal cannabis plant extract with less than 0.3% Δ9-tetrahydrocannabinol in in vitro models of inflammation and excitotoxicity
Even at nanomolar concentrations, CBD acts as a negative allosteric modulator of the adenosine A2A receptor (where caffeine binds)
Cannabidiol at Nanomolar Concentrations Negatively Affects Signaling through the Adenosine A2A Receptor
How CBD modulates the ion channels of the brain
Cannabidiol Modulates M-Type K+ and Hyperpolarization-Activated Cation Currents
In dental stem cells, cannabis extracts increased their proliferation & viability
In Vitro Assessment of Morphology, Proliferation, Apoptosis and Differential Potential of Dental Pulp Stem Cells, When Marijuana Is Added to Nutrients of Cell Culture Medium
In a mouse model of MS, the terpene eugenol lowered their neuroinflammatory response & clinical symptoms
Eugenol alleviates the symptoms of experimental autoimmune encephalomyelitis in mice by suppressing inflammatory responses