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Research Roundup: Feb 13, 2024



Best of cannabinoid science this week...


In people with treatment resistant epilepsy, CBD lowered their brain temperature levels as well as their seizure severity

The longitudinal effects of cannabidiol on brain temperature in patients with treatment-resistant epilepsy

And in infants with epileptic spasms, CBD caused a more than 50% reduction with good tolerability

Purified cannabidiol as add-on therapy in children with treatment-resistant infantile epileptic spasms syndrome


A meta-analysis of PTSD studies found cannabis use associated with significant improvements

Cannabis use and trauma-focused treatment for co-occurring posttraumatic stress disorder and substance use disorders: A meta-analysis of individual patient data


In humans, topical CBD reached its peak blood concentration after 7 to 10 days of product use (with no positive urine tests, but some positive oral fluid tests)

Pharmacokinetics and Pharmacodynamics of Five Distinct Commercially Available Hemp-derived Topical Cannabidiol (CBD) Products


In public health data about heart failure hospitalizations, cannabis use was associated with decreased mortality & length of stay

Cannabis Use Is Associated With Decreased Mortality And Length Of Stay In Heart Failure Hospitalizations


Cannabis use is growing among adult MS patients with chronic pain

Growing cannabis use among Multiple Sclerosis adults with chronic pain; An analysis from the United States


A review on the neurotherapeutic arsenal of cannabis

The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effects


For ALS, a review of the dysregulated endocannabinoid system as a therapeutic target

Dysregulated expanded endocannabinoid system as therapeutic targets of amyotrophic lateral sclerosis


A meta-analysis of 10 studies of people with opioid use disorder, there is no association between their cannabis use & non-medical opioid use

The impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies


A review of your food intake regulation system & the role of the CB2 receptor

Role of the CB2 Cannabinoid Receptor in the Regulation of Food Intake: A Systematic Review


A review of the ECS & your glymphatic system (a recently discovered waste clearance system of the brain)

Interplay between the Glymphatic System and the Endocannabinoid System: Implications for Brain Health and Disease


In a mouse model of heart failure, CBD was protective via anti-inflammatory effects

Cannabidiol As A Potential Treatment For Heart Failure With Preserved Ejection Fraction


In a mouse model of osteoarthritis, CBD oil & CBG oil lowered pain & inflammation & helped to protect their local motor activity while the CBG oil reduced cartilage degeneration

Therapeutic Effects of Non-Euphorigenic Cannabis Extracts in Osteoarthritis


In a rat model of lung scarring, CBD reduced the symptoms via the gut microbiome

Integrating fecal metabolomics and intestinal microbiota to study the mechanism of cannabidiol in the treatment of idiopathic pulmonary fibrosis


In brain cells, a CBD rich extract caused anti-inflammatory & neuroprotective effects

Evaluation of the efficacy of a full-spectrum medicinal cannabis plant extract with less than 0.3% Δ9-tetrahydrocannabinol in in vitro models of inflammation and excitotoxicity


Even at nanomolar concentrations, CBD acts as a negative allosteric modulator of the adenosine A2A receptor (where caffeine binds)

Cannabidiol at Nanomolar Concentrations Negatively Affects Signaling through the Adenosine A2A Receptor


How CBD modulates the ion channels of the brain

Cannabidiol Modulates M-Type K+ and Hyperpolarization-Activated Cation Currents


In dental stem cells, cannabis extracts increased their proliferation & viability

In Vitro Assessment of Morphology, Proliferation, Apoptosis and Differential Potential of Dental Pulp Stem Cells, When Marijuana Is Added to Nutrients of Cell Culture Medium


In a mouse model of MS, the terpene eugenol lowered their neuroinflammatory response & clinical symptoms

Eugenol alleviates the symptoms of experimental autoimmune encephalomyelitis in mice by suppressing inflammatory responses


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