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Research Roundup: Dec 27, 2023

Best of cannabinoid science this week...

In a small study of people with PTSD, medical cannabis use improve their mental health & symptom severity scores, especially in reductions of nightmares & improved sleep quality

Improved Post-Traumatic Stress Disorder Symptoms and Related Sleep Disturbances after Initiation of Medical Marijuana Use: Evidence from a Prospective Single Arm Pilot Study

In a Thai study of neuropathic pain patients, cannabis caused almost half of them to have at least a 30% reduction of pain scores & many saw significant improvements in quality of life, especially sleep - but as always around 10% could not tolerate this side effects & had to stop using medical cannabis

Efficacy and Safety of Medical Cannabis in Neuropathic Pain Patients

And this review of how the cannabinoids & beta caryophyllene help with neuropathic pain

IUPHAR review- Preclinical models of neuropathic pain: Evaluating multifunctional properties of natural cannabinoid receptors ligands

In people using cannabis to cope with anxiety, they had better sleep on the days they used cannabis, but not after alcohol use

Daily diary study of associations between alcohol, cannabis, co-use and sleep quality in individuals with intentions to use cannabis to cope with anxiety

A genome association study & public health data do not support an association between cannabis use & developing glaucoma

Cannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization study

In dogs, the tolerability of 36 weeks of CBD

Tolerability of long-term cannabidiol supplementation to healthy adult dogs

A dose of 5 mg/kd/day was well tolerated. At 10 mg/kg/day, this group had a higher frequency of soft feces. And in all treatment groups, they had high ALP liver enzyme activity, but that was the only difference found in the blood work.

In horse’s trigeminal ganglions (the nerve that gathers sensory stimuli from the head), they had CB1, CB2, TRPV1 & PPAR receptors

Expression of Cannabinoid Receptors in the Trigeminal Ganglion of the Horse

A review of cannabinoids for stress responses & coping (with some great charts on the diversity of their effects & binding)

Anxiety Modulation by Cannabinoids-The Role of Stress Responses and Coping

For the cognitive dysfunction of Alzheimer's disease, the role of the endocannabinoid system in the brain’s astrocytes (key support cells that make up the majority of cells in the CNS)

Interplay Between Astroglial Endocannabinoid System and the Cognitive Dysfunction in Alzheimer's Disease

In rats, cannabis extracts protected the kidneys from a drug that causes nephrotoxicity

Therapeutic Effect of Lebanese Cannabis Oil Extract in the Management of Sodium Orthovanadate-Induced Nephrotoxicity in Rats

A thesis project in roundworms finds that the pain fighting activity of CBD & THC are mediated by distinct receptors

Cannabidiol and tetrahydrocannabinol antinociceptive activity is mediated by distinct receptors in caenorhabditis elegans

A computer study of CBD analogs for treating Alzheimer's disease

An In Silico Study for Expanding the Utility of Cannabidiol in Alzheimer's Disease Therapeutic Development

A cannabinoid secreting trichrome found in the Jamaican nettletree (Trema micranthum)

The putative cannabinoid-secreting trichome of Trema micrantha (L.) Blume (Cannabaceae)


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