Best of cannabinoid science this week...
In a clinical sleep trial using 200 mg of CBD & 10 mg of THC, people got to sleep faster, spent less time in REM sleep (that’s why weed steals dreams) & did not impair next-day cognitive performance Acute effects of combined cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC) in insomnia disorder: A randomised, placebo-controlled trial using high-density EEG https://academic.oup.com/sleepadvances/article/3/Supplement_1/A3/6811668
In a survey of humans with Tourette’s syndrome, while THC & CBD did not help with tics, it did help to improve several other areas such as OCD, anxiety, employment status & general quality of life
Use of Medical Cannabis in Patients with Gilles de la Tourette's Syndrome in a Real-World Setting
In humans taking THC capsules, their biomarkers indicated that they had less bone resorption (ie: more bone growth) Serum Markers of Bone Turnover Following Controlled Administration of Two Medical Cannabis Products in Healthy Adults https://pubmed.ncbi.nlm.nih.gov/36346322
In this review, 31 studies on CBD for chronic facial pain & disorders of the jaw muscles & joints CBD in orofacial pain and TMD - a literature review https://assets.researchsquare.com/files/rs-2184263/v1_covered.pdf
A review of using CBD to treat cannabis use disorder Cannabidiol pharmacotherapy for delta-9-tetrahidrocannabinol dependence https://pubmed.ncbi.nlm.nih.gov/36219190
For anxiety, a review of 58 studies on the use of THC & CBD found an inverted U-shaped dose relationship: as usual, a moderate amount is good & a lot is not helpful Cannabinoid treatments for anxiety: A systematic review and consideration of the impact of sleep disturbance https://pubmed.ncbi.nlm.nih.gov/36370842
A review of 5 studies using cannabinoids for gut problems in young patients Therapeutic Effects of Medicinal Cannabinoids on the Gastrointestinal System in Pediatric Patients: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/36219741
A review of cannabis for treating metabolic syndrome (the cluster of factors leading to heart disease, atherosclerosis, type 2 diabetes) Cannabis and cannabinoids as an alternative remedy in metabolic syndrome https://www.scielo.br/j/bjps/a/TK3d386LXg3HbxvT7zZpJzM
A nice review of the endocannabinoid system with good charts
Endocannabinoid System: Chemical Characteristics and Biological Activity
In healthy dogs, CBD capsules for 6 months was well-tolerated & saw no biochemistry or liver changes asides from a passing elevation in ALP liver levels in half the dogs Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs https://pubmed.ncbi.nlm.nih.gov/36213402
In female rats exposed to fear conditioning, CBD reduced their anxiety responses via the dopamine/serotonin axis in the hippocampus (memory center) Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT1A but not CB1 or CB2 receptors https://pubmed.ncbi.nlm.nih.gov/36334768
In a rat model of rheumatic arthritis, a nano-CBD water caused an improvement in their clinical symptoms Application of Oil-in-Water Cannabidiol Emulsion for the Treatment of Rheumatoid Arthritis https://pubmed.ncbi.nlm.nih.gov/36342775