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Research Roundup: Dec 12, 2023



Best of cannabinoid science this week...


In a study of people using CBD for a month, they saw significant changes in their measures for pain, mental health & sleep with the greatest improvements for pain & with many stopping their use of over the counter or prescription drugs Long-Term, Self-Dosing CBD Users: Indications, Dosage, and Self-Perceptions on General Health/Symptoms and Drug Use

 

For chronic pain patients, a survey of the forms of cannabis they used

Comparing Cannabis Use for Pain to Use for Other Reasons in Primary Care Patients

 

Brain scans show regular cannabis users have higher empathy related differences in their brain’s anterior cingulate cortex

Empathy-related differences in the anterior cingulate functional connectivity of regular cannabis users when compared to controls

In seasonal allergies, Gencor sponsored a study that shows PEA (350 mg for 2 weeks) reduced their symptoms & inflammatory markers

 

In a small trial of people with irritable bowel syndrome, a mix of CBD & CBG reduced abdominal pain

Proof of Concept Open Label Trial of CBD/CBG Oral Tincture in the Management of Symptoms in Adult Patients With Irritable Bowel Syndrome

And similar positive results with CBD for gastroparesis (delayed gastric emptying)

Cannabidiol: A Potential Therapeutic Option for Idiopathic and Diabetic Gastroparesis

 

For obesity, a meta-analysis found that cannabis use reduced weight & waist circumference

Effect of cannabis and subproducts on anthropometric measures: a systematic review and meta-analysis

And in patients with metabolic syndrome, an inverse agonist of the CB1 receptor caused significant weight loss as well as reduction of waist circumference & body mass index

Effects of CB1R inverse agonist, INV-202, in patients with features of metabolic syndrome. A randomized, placebo-controlled, double-blind phase 1b study

 

In a double-blind trial for exercise, beverages of CBD & CBG improved soreness & stiffness

A randomized, double-blind, placebo-controlled, repeated-dose pilot study of the safety, tolerability, and preliminary effects of a cannabidiol (CBD)- and cannabigerol (CBG)-based beverage powder to support recovery from delayed onset muscle soreness (DOMS)

 

A case report of a fibromyalgia patient successfully using a homeopathic preparation of cannabis

Successful Treatment of a Fibromyalgia Patient Using a Homeopathic Preparation of Cannabis sativa


A Canadian program about alcohol misuse about the potential for cannabis as a substitute

Translating the lived experience of illicit drinkers into program guidance for cannabis substitution: Experiences from the Canadian Managed Alcohol Program Study

 

In people with gambling disorders, they had higher fasting levels of anandamide & the levels of their anandamide & 2AG were related to gambling disorder severity, suggesting the ECS as a treatment target

Anandamide and 2-arachidonoylglycerol baseline plasma concentrations and their clinical correlates in gambling disorder


A series on many uses of CBD & medical cannabis

Editorial: Medicinal Cannabis: evolution of therapeutic use, future approaches and other implications, volume II


For people with intellectual disability, on using medical cannabis to help manage challenging behaviors

The potential for medicinal cannabis to help manage challenging behaviour in people with intellectual disability: A perspective review


For chronic pain, a review of 15 studies

Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic Review


A review of cannabis for rheumatoid arthritis

Cannabis and Rheumatoid Arthritis: A Scoping Review Evaluating the Benefits, Risks, and Future Research Directions

 

A review of using CBD for mucosal diseases of the gut & lungs

Cannabidiol - Help and hype in targeting mucosal diseases


In middle-aged female rats exposed to social isolation, CBD protected from measures of anxiety & depression as well as causing increased levels of the brain growth factor BDNF

Cannabidiol Modulates Emotional Function and Brain-Derived Neurotrophic Factor Expression in Middle-Aged Female Rats Exposed to Social Isolation

 

In an animal model of an incisional wound, cannabis essential oil accelerated healing as well as lowering cortisol (a stressor that slows the healing process)

Wound healing efficacy of Cannabis sativa L. essential oil in a mouse incisional wound model: A possible link with stress and anxiety

 

In rats being treated with the anti-cancer agent methotrexate, CBD lowered neuroinflammation & neuronal apoptosis (cellular suicide) via the mitochondria & endoplasmic reticulum

The ameliorative effects of cannabidiol on methotrexate-induced neuroinflammation and neuronal apoptosis via inhibiting endoplasmic reticulum and mitochondrial stress


For endometriosis, mouse models showed that the endocannabinoid system modulated disease progression & immune response

Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response


In an animal model of chronic inflammatory pain, electroacupuncture reduced pain via the CB1 receptor in the anterior cingulate cortex (a brain are of emotional regulation, pain perception & cognitive control)

Electroacupuncture Exerts Analgesic Effects by Restoring Hyperactivity via Cannabinoid Type 1 Receptors in the Anterior Cingulate Cortex in Chronic Inflammatory Pain


A study of how CBD alters the ionic currents of the brain, specifically potassium

Cannabidiol Modulates M-Type K+ and Hyperpolarization-Activated Cation Currents

 

In a tissue model of brain cells, the terpene beta-caryophyllene protected from the toxicity of the heavy metal cadmium

Beta-Caryophyllene, a Plant-Derived CB2 Receptor Agonist, Protects SH-SY5Y Cells from Cadmium-Induced Toxicity


In cow gut cells, CBD reduced inflammation via modulation of the immune system

Effects of Cannabidiol on Viability and Inflammatory Response in Bovine Primary Ruminal Epithelial Cells


In a rat model of insulin resistance, CBG modulated the metabolism of sphingolipid (an important class of lipids) & potentially protected the liver against metabolic disorders

How Does CBG Administration Affect Sphingolipid Deposition in the Liver of Insulin-Resistant Rats?

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