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Research Roundup: Aug 9, 2021



Best of the Week...


A paper looking at the lifestyle interventions that might improve your endocannabinoid tone during a pandemic

Lifestyle Interventions Improving Cannabinoid Tone During COVID-19 Lockdowns May Enhance Compliance With Preventive Regulations and Decrease Psychophysical Health Complications

https://pubmed.ncbi.nlm.nih.gov/34335317/


In humans with cocaine use disorder, CBD caused anti-inflammatory effects

Exploring cannabidiol effects on inflammatory markers in individuals with cocaine use disorder: a randomized controlled trial

https://pubmed.ncbi.nlm.nih.gov/34331010/


A survey of spinal patients found that many of them found CBD helpful for treating their pain, improving their sleep & reducing their anxiety

Prevalence of Cannabidiol Use in Patients With Spine Complaints: Results of an Anonymous Survey

https://pubmed.ncbi.nlm.nih.gov/34285125/


In diabetic humans with painful neuropathy in their feet, 20 mg of water solubilized CBD reduced pain, improved sleep & reduced anxiety

Cannabidiol (CBD) For the Treatment of Painful Diabetic Peripheral Neuropathy of the Feet: A Placebo-Controlled, Double-Blind, Randomized Trial

https://www.longdom.org/abstract/cannabidiol-cbd-for-the-treatment-of-painful-diabetic-peripheral-neuropathy-of-the-feet-a-placebocontrolled-doubleblind--77161.html


In honey bees, hemp extracts improved their immune systems

Cannabis Extract Has a Positive–Immunostimulating Effect through Proteolytic System and Metabolic Compounds of Honey Bee (Apis mellifera) Workers

https://www.mdpi.com/2076-2615/11/8/2190

“The busy bee has no time for sorrow.” - Blake


In a rat model of a traumatic brain injury, CBD improved the integrity of the blood-brain barrier & reduced edema (brain swelling from excess fluids)

Effects of cannabinoid (CBD) on blood brain barrier permeability after brain injury in rats

https://pubmed.ncbi.nlm.nih.gov/34289379/


A review of using the cannabinoids to treat autoimmune disorders with a focus on their epigenetic control of genes regulating inflammation (nice chart)

Epigenetic Regulation of Cannabinoid-Mediated Attenuation of Inflammation and Its Impact on the Use of Cannabinoids to Treat Autoimmune Diseases

https://pubmed.ncbi.nlm.nih.gov/34298921/


New research from Di Marzo presents the first evidence that CBD acts an antagonist at an orexin receptor (a key neurotransmitter that regulates in arousal, the sleep/wake cycle & in the motivation and reward processes involved in addiction)

Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation

https://www.mdpi.com/2218-273X/11/8/1134/htm


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

A review of the studies on the use of CBD in sports

The role of cannabidiol in professional sports: A scoping review

https://sportsmedicine.co.nz/wp-content/uploads/2021/02/NZ-Journal-of-Sports-Medicine-2020-Vol-47-2.pdf#page=13


This survey of epilepsy patients shows several improvements for users of “artisanal CBD products” including “higher quality of life, lower psychiatric symptom severity, and improved sleep”

Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy

https://pubmed.ncbi.nlm.nih.gov/34311183/


A long-term study of patients with Lennox-Gastaut Syndrome found CBD to be a safe & effective add-on to current treatments

Long-term safety and efficacy of add-on cannabidiol in patients with Lennox-Gastaut syndrome: Results of a long-term open-label extension trial

https://pubmed.ncbi.nlm.nih.gov/34287833/


A survey of why people are using CBD

The emerging role of cannabidiol (CBD) products; a survey exploring the public's use and perceptions of CBD

https://pubmed.ncbi.nlm.nih.gov/34350641/


In humans with Tourette’s, initial promise was seen with a combination of 10 mg of THC + 800 mg of PEA

A Phase-2 Pilot Study of a Therapeutic Combination of Δ 9-Tetrahydracannabinol and Palmitoylethanolamide for Adults With Tourette's Syndrome

https://pubmed.ncbi.nlm.nih.gov/34340527/


In canines, the researchers looked at how 3 weeks of CBD treats altered the dog’s metabolomics

Alteration of the Canine Metabolome After a 3-Week Supplementation of Cannabidiol (CBD) Containing Treats: An Exploratory Study of Healthy Animals

https://pubmed.ncbi.nlm.nih.gov/34336977/


This review looks at the use of cannabinoids for the treatment of endometriosis and chronic pelvic pain in women

Cannabinoids and chronic pelvic pain in women: Focus on endometriosis

https://journals.sagepub.com/doi/abs/10.1177/22840265211011277


An overview of how the cannabinoids may help with heart diseases

An overview on plants cannabinoids endorsed with cardiovascular effects

https://pubmed.ncbi.nlm.nih.gov/34332376/


A review of how the endocannabinoids regulate synaptic plasticity

Mechanisms of endocannabinoid control of synaptic plasticity

https://pubmed.ncbi.nlm.nih.gov/34343612/

Preclinical Research & Cannabinoid Chemistry

In a rat model of tonic pain, the injection of CBD into the brain’s nucleus accumbens (a major mediating center of analgesics for pain) lessened the pain response

Cannabidiol microinjection into the nucleus accumbens attenuated nociceptive behaviors in an animal model of tonic pain

https://pubmed.ncbi.nlm.nih.gov/34324957/


In mouse neurons, the repeated use of cocaine (but not heroin) increased CB2 receptors in the dopamine neurons of the midbrain as well as the brain’s cortex & striatum (primarily the nucleus accumbens) as well as the spleen

Repeated cocaine administration upregulates CB 2 receptor expression in striatal medium-spiny neurons that express dopamine D 1 receptors in mice

https://pubmed.ncbi.nlm.nih.gov/34316031/


Research in mice shows 2-AG to be the endocannabinoid neurotransmitter most associated with the control of neurotransmitter release & neuronal signaling

In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity

https://pubmed.ncbi.nlm.nih.gov/34352214/


In stem cells of the soft tissue connecting the teeth, the endocannabinoids regulate their genes & expression using a pathway other than the cannabinoid or TRPV1 receptors

Endocannabinoids Regulate Stem Cells of The Apical Papilla in A Cannabinoid Receptors and TRPV1-Independent Pathway

https://pubmed.ncbi.nlm.nih.gov/34293356/


In the mouse brain, THC promotes remyelination

Δ9-Tetrahydrocannabinol promotes functional remyelination in the mouse brain

https://www.researchgate.net/profile/Javier-Palazuelos/publication/352967337_D_9_-Tetrahydrocannabinol_promotes_functional_remyelination_in_the_mouse_brain/links/6108e552169a1a0103d459ef/D-9-Tetrahydrocannabinol-promotes-functional-remyelination-in-the-mouse-brain.pdf