Best of cannabinoid science this week...
In fibromyalgia patients, THC caused significant improvements in pain intensity, depression & quality of life as well as a reduction in painkiller usage Tetrahydrocannabinol (THC) in patients with fibromyalgia syndrome (FMS) : A retrospective study of changes in pain, psychometric variables, and analgesic consumption during inpatient interdisciplinary multimodal pain therapy (IMPT) https://pubmed.ncbi.nlm.nih.gov/37289246/
In a person with chronic pain of the jaw bone & muscles, full-spectrum CBD produced excellent results & remarkable improvements in quality of life Full-Spectrum Cannabidiol for Treating Chronic Temporomandibular Arthralgia: A Case Report https://www.liebertpub.com/doi/pdf/10.1089/imr.2023.0002
Hair growth in alopecia patients with full-spectrum hemp extracts Hair Regrowth with Novel Hemp Extract: A Case Series https://pubmed.ncbi.nlm.nih.gov/37305187/
For long COVID, a small safety study on using CBD found no problems Feasibility of a cannabidiol (CBD)-dominant cannabis based medicinal product (CBMP) for the treatment of Long COVID symptoms: A single arm open label feasibility trial https://europepmc.org/article/ppr/ppr686531
In interviews of Canadian veterans using cannabis, most reported improvements in their overall quality of life, sleep, relationships, mood & pain cViews on and experiences with medicinal cannabis among Canadian Veterans who live with pain: A qualitative study https://www.tandfonline.com/doi/pdf/10.1080/24740527.2023.2232838 And an editorial on the use of cannabinoids for pain & PTSD by military personnel & veterans Cannabis and Cannabinoids for Pain and Posttraumatic Stress Disorder in Military Personnel and Veterans https://pubmed.ncbi.nlm.nih.gov/37436761/
In healthy cats, the bioavailability of CBD increased 10 times when administered with a meal Disposition of a single oral dose of a cannabidiol medication in healthy cats https://pubmed.ncbi.nlm.nih.gov/37303724/
On CBD for aging The role of cannabidiol in aging https://pubmed.ncbi.nlm.nih.gov/37418976/
In binge eating disorders, a review of the role of the endocannabinoid system (good charts) The Role of the Endocannabinoid System in Binge Eating Disorder https://pubmed.ncbi.nlm.nih.gov/37298525/
On Alzheimer's disease & the related depression, a review of using the cannabinoids Under the umbrella of depression and Alzheimer's disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy? https://pubmed.ncbi.nlm.nih.gov/37414155/
In a male mouse model of autism, CBD enhanced their social interactions Acute cannabidiol treatment enhances social interaction in adult male mice https://pubmed.ncbi.nlm.nih.gov/37273836/
In a mouse model of inflammation from acute stress, pretreatment with full spectrum hemp extracts lowered the inflammation & stress hormone response, though less effectively in females Oral CBD-rich hemp extract modulates sterile inflammation in female and male rats https://pubmed.ncbi.nlm.nih.gov/37275221/
In a mouse model of peripheral nerve injuries (one of the most complex medical conditions with no effective first line treatment), the ability of cannabis leaf extract to restore muscle function & speed up recovery Comparative evaluation of ethyl acetate and n-Hexane extracts of Cannabis sativa L. leaves for muscle function restoration after peripheral nerve lesion https://pubmed.ncbi.nlm.nih.gov/37324902/
In mouse models of several types of pain, encapsulated CBD rich hemp extracts lowered pain with increased bioavailability Evaluation of the Analgesic Effect of High-Cannabidiol-Content Cannabis Extracts in Different Pain Models by Using Polymeric Micelles as Vehicles https://pubmed.ncbi.nlm.nih.gov/37298776/
In rats that had been using methamphetamine for 10 days & were now abstinent, injections of CBD enhanced levels of brain growth factors Cannabidiol Modulating the Expression of Neurotrophin Signaling Pathways in Chronic Exposure to Methamphetamine in Rats During Abstinence Period https://pubmed.ncbi.nlm.nih.gov/37313028/
A mouse safety study of a full spectrum hemp extract found no negative changes
Toxicological safety assessment of HempChoice® hemp oil extract; a proprietary extract consisting of a high concentration of cannabidiol (CBD) in addition to other phytocannabinoids and terpenes derived from Cannabissativa L
In a fruit fly model of Fragile X syndrome, early administration of CBDV lower is the newer inflammation & prevents the neurobehavioral abnormalities Early Administration of the Phytocannabinoid Cannabidivarin Prevents the Neurobehavioral Abnormalities Associated With the Fmr1-Ko Mouse Model of Fragile X Syndrome https://www.preprints.org/manuscript/202307.0140/v1
A structural study of how CBD is a negative modulator of a key opioid receptor Structure-Activity Relationship Study of Cannabidiol-Based Analogs as Negative Allosteric Modulators of the μ-Opioid Receptor https://pubmed.ncbi.nlm.nih.gov/37437224/