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Research Roundup: Aug 29, 2023



Best of cannabinoid science this week...


In patients with gastroparesis (slowed or stopped movement of food from the stomach to the intestines), a double-blind trial of CBD found that it improved their gastroparesis scores & symptom severity as well as lowering the number of vomiting episodes A Randomized, Controlled Trial of Efficacy and Safety of Cannabidiol in Idiopathic and Diabetic Gastroparesis https://pubmed.ncbi.nlm.nih.gov/37482172/ Plus a review on CBD & intestinal motility as well as the help for diseases such as colitis Cannabidiol and Intestinal Motility: a Systematic Review https://www.sciencedirect.com/science/article/pii/S2475299123247952


A survey of ALS patients on how they find cannabis & CBD to be helpful Cannabis for the treatment of amyotrophic lateral sclerosis: What is the patients' view? https://pubmed.ncbi.nlm.nih.gov/37460332/ “Participants mostly reported the use of cannabidiol (CBD) oil and cannabis weed and declared benefits both on motor (rigidity, cramps, fasciculations) and non-motor (sleep quality, pain, emotional state, quality of life, depression) symptoms and only eight reported minor adverse reactions (drowsiness, euphoria and dry mouth).”


Interviews of caregivers for childhood epilepsies find CBD to have a wide range of beneficial effects beyond seizure control Caregivers' Perspectives on the Impact of Cannabidiol (CBD) Treatment for Dravet and Lennox-Gastaut Syndromes: A Multinational Qualitative Study https://pubmed.ncbi.nlm.nih.gov/37455396/


A survey of 500+ US veterans finds that the most common uses are for chronic pain, PTSD, anxiety & depression, that it allows them to reduce their medication usage (including opioids) & over 90% report that cannabis gives them a greater quality of life Self-reported Medicinal Cannabis Use as an Alternative to Prescription and Over-the-counter Medication Use Among US Military Veterans https://pubmed.ncbi.nlm.nih.gov/37414507/


A survey of people who use opioids find that they feel cannabis is helpful for reducing their opioid usage Cannabis use to manage opioid cravings among people who use unregulated opioids during a drug toxicity crisis https://pubmed.ncbi.nlm.nih.gov/37481875/


A review of why CBD seems to help for hair loss & alopecia CBD: A Potential Lead against Hair Loss, Alopecia, and its Potential Mechanisms https://pubmed.ncbi.nlm.nih.gov/37475557/


In diabetes, a review of the therapeutic potential of CBD The pharmacology and therapeutic role of cannabidiol in diabetes https://onlinelibrary.wiley.com/doi/pdf/10.1002/EXP.20230047


In multiple sclerosis, a review of 25 studies on the effects of the cannabinoids

Cannabis and cannabinoids for symptomatic treatment for people with multiple sclerosis


A review of the role of the CB1 receptors in the neurodegeneration of Alzheimer's, Parkinson's & Huntington's disease An enquiry to the role of CB1 receptors in neurodegeneration https://pubmed.ncbi.nlm.nih.gov/37481040/


A review of the crosstalk between the neuroendocrine system & bone homeostasis Crosstalk between the neuroendocrine system and bone homeostasis https://pubmed.ncbi.nlm.nih.gov/37459436/


In a thesis project using a mouse model of autism, CBD helped to lessen the social deficits Pharmacotherapeutic effects of cannabidiol in autism spectrum disorders https://repository.library.carleton.ca/concern/etds/2z10wr268


A commentary on how CBD lowers hyperactivity in the hippocampus, perhaps by the LPI-GPR55 signaling pathway (an understudied component of the endocannabinoid system) Cannabidiol Keeps Hippocampal Hyperactivity in Check https://journals.sagepub.com/doi/full/10.1177/15357597231186917


In a study of acne, they highlight CBD as an effective drug for restoring lipid balance as well as lowering oxidative stress & inflammation In vitro acne disease model from inertial focusing effect for studying the interactions between sebocyte glands and macrophages https://pubmed.ncbi.nlm.nih.gov/37477791/


In adolescent rats prenatally exposed to THC, CBD enhanced their cognitive scores & fine-tuned the plasticity in their hippocampus (memory center of the brain) CBD enhances the cognitive score of adolescent rats prenatally exposed to THC and fine-tunes relevant effectors of hippocampal plasticity https://pubmed.ncbi.nlm.nih.gov/37583903/


In rats with chronic nerve pain, CBD reduce hyperactivity of the pain neurons & reduced activation in the corticolimbic system Cannabidiol modulates chronic neuropathic pain aversion behavior by attenuation of neuroinflammation markers and neuronal activity in the corticolimbic circuit in male Wistar rats https://pubmed.ncbi.nlm.nih.gov/37474023/

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