Best of cannabinoid science this week...
In patients with PTSD who have an anxiety disorder, formulas of CBD & THC significantly improved anxiety, depression, fatigue & social abilities The Effectiveness and Adverse Events of Cannabidiol and Tetrahydrocannabinol Used in the Treatment of Anxiety Disorders in a PTSD Subpopulation: An Interim Analysis of an Observational Study https://journals.sagepub.com/doi/pdf/10.1177/87551225231180796
In COVID patients with olfactory dysfunction, a combination of PEA & luteolin (an anti-inflammatory flavonoid frequently combined with PEA) paired with olfactory training improved their olfactory recovery Treatment of COVID-19 olfactory dysfunction with olfactory training, palmitoylethanolamide with luteolin, or combined therapy: a blinded controlled multicenter randomized trial https://pubmed.ncbi.nlm.nih.gov/37380908/
In chronic pain patients, cannabis use lowered painkiller usage, and in female patients, reduced levels of pro inflammatory cytokines & cortisol
Self-Reported Medical Cannabis Use and Inflammatory Cytokines and Chemokines in Chronic Pain Patients
In fibromyalgia, the standard treatment of pregabalin & duloxetine was enhanced by the addition of PEA & acetyl-L-carnitine with significant improvements in disease severity & pain Palmitoylethanolamide and acetyl-L-carnitine act synergistically with duloxetine and pregabalin in fibromyalgia: results of a randomised controlled study https://pubmed.ncbi.nlm.nih.gov/37378482/
For cancer patients in South Carolina (a state with no medical cannabis), those using it illegally endorsed it for pain, anxiety & depression, difficulty sleeping & loss of appetite Cannabis use prevalence, patterns, and reasons for use among patients with cancer and survivors in a state without legal cannabis access https://pubmed.ncbi.nlm.nih.gov/37382737/
A review of how endocannabinoids are causing new neuron growth in the adult hippocampus (memory center of the brain) Endocannabinoid signaling in adult hippocampal neurogenesis: A mechanistic and integrated perspective https://pubmed.ncbi.nlm.nih.gov/37385352/
A review of 13 studies of PEA in psychosis finds its potential as a psychosis biomarker as well as a potential therapeutic treatment Questioning the role of palmitoylethanolamide in psychosis: a systematic review of clinical and preclinical evidence https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1231710/full
For ADHD, a review of 20 studies on the effects of cannabis Evaluation of Efficacy of Cannabis Use in Patients With Attention Deficit Hyperactivity Disorder: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/37503496/
In asthma, on using dietary fatty acids to boost the endocannabinoid system for the control of chronic inflammation Polyunsaturated fatty acids and lipid mediators controlling chronic inflammation in asthma https://romj.org/files/pdf/2023/romj-2023-0201.pdf
A review of 29 studies on the use of cannabinoids in children with epilepsy The use of cannabinoids in children with epilepsy: A systematic review https://pubmed.ncbi.nlm.nih.gov/37390729/
On protecting skin stem cells from UV radiation with cannabis oil Vegetable Oil-Based Cannabis: Its Cannabinoid Profiling and Photoprotectivotective Effect on UVA-Irradiated Human Skin Keratinocytes https://digital.car.chula.ac.th/cgi/viewcontent.cgi?article=2658&context=tjps
In a mouse model of autism, the effects of CBD on prosocial behavior & BDNF levels (and important neural growth factor) Developmental intervention with CBD on BDNF levels and prosocial behavior in a mouse model of autism spectrum disorder https://cedar.wwu.edu/cgi/viewcontent.cgi?article=1644&context=wwu_honors
In a mouse model of arthritis, CBD & CBC produce greater anti-inflammatory effects when working together The Mechanism of Cannabichromene and Cannabidiol Alone Versus in Combination in the Alleviation of Arthritis-Related Inflammation https://pubmed.ncbi.nlm.nih.gov/37332213/
In mice with HIV, CBC helps with pain & neuroinflammation Effects of Cannabichromene on Pain and Neuroinflammation in HIV-1 TAT Transgenic Mice https://egrove.olemiss.edu/cgi/viewcontent.cgi?article=3956&context=hon_thesis
In rats, CBC treatment increased the activity of antioxidant enzymes in a number of organs, decreased liver function enzymes & caused kidney function changes that made the researchers recommend caution in the use of CBC Dose–response evaluation of cannabichromene on hepato-renal enzyme and non-enzyme biomarkers: the pharmacological controlled study https://link.springer.com/article/10.1007/s00580-023-03491-0
In eye cells, the novel endocannabinoid N-oleoyl dopamine (OLDA) acts not via the CB1 receptor but by the GPR119, GPR6 & TRPV1 receptors to lower their conversion into scar tissue, suggesting a treatment for ocular diseases Effect of N-oleoyl dopamine on myofibroblast trans-differentiation of retinal pigment epithelial cells https://pubmed.ncbi.nlm.nih.gov/37216828/
In a mouse model of neuropathic pain, the ability of the kratom alkaloid mitragynine to lower pain seems to be mediated by the cannabinoid receptors Cannabinoid mechanisms contribute to the therapeutic efficacy of the kratom alkaloid mitragynine against neuropathic, but not inflammatory pain https://pubmed.ncbi.nlm.nih.gov/37392779/
On the antifungal & antibacterial effects of cannabis extracts Antifungal and antibacterial activities of Cannabis sativa L. resins https://pubmed.ncbi.nlm.nih.gov/37400009/
In a cellular model of oxidative damage, CBD pre-treatment increased cell viability & antioxidant related enzyme activity as well as lowering the levels of reactive oxygen species with a free radical scavenging capacity comparable to that of a typical natural antioxidant Protective Effect of Cannabidiol on Hydrogen Peroxide-Induced Oxidative Damage in Human Umbilical Vein Endothelial Cells (HUVECs) https://pubmed.ncbi.nlm.nih.gov/37382028/
In brain blood vessel cells, a drug that activates both the CB1 & CB2 receptor increased factors related to angiogenesis (new blood vessel growth) The expression analyses of GSK3B, VEGF, ANG1, and ANG2 in human brain microvascular endothelial cells treated with the synthetic cannabinoid XLR-11 https://pubmed.ncbi.nlm.nih.gov/37355149/
In a rat model of overexcited brains (a hallmark of epilepsy), activating the cannabinoid receptors reduced the activity via calcium levels Activation of the Cannabinoid Receptors Suppresses Hyperexcitation of Rat Hippocampal Neuronal Networks In Vitro https://link.springer.com/article/10.1134/S1990747823030078
On how CBD modulates the potassium channels to cause its anticonvulsant effects
Subtype-specific modulation of human KV 7 channels by the anticonvulsant cannabidiol through a lipid-exposed pore-domain site
In a mouse model of obesity, oleoylethanolamide (an analog of anandamide) reduced systemic inflammation via the lowering of cellular inflammatory reactions & proinflammatory cytokine levels as well as suppressing the production of reactive oxygen species by immune cells Effect of oleoylethanolamide on systemic inflammation in the development of alimentary induced obesity in mice https://assets.researchsquare.com/files/rs-3094720/v1/97dbdddc-244a-43c9-93fa-22084d7f07e9.pdf?c=1688316273