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Research Roundup: Sep 19, 2022



Best of cannabinoid science this week...


In unvaccinated adults with COVID-19, PEA reduced their pro-inflammatory markers & caused an anti-inflammatory effect (hattip to Col. Dr. Michael Lewis)

Palmitoylethanolamide Reduces Proinflammatory Markers in Unvaccinated Adults Recently Diagnosed with COVID-19: A Randomized Controlled Trial

https://pubmed.ncbi.nlm.nih.gov/36084236


In a review of cannabinoids & high blood pressure treatments, while the endocannabinoids did not help because of their contradictory actions, CBD effectively treated pulmonary hypertension

Why Multitarget Vasodilatory (Endo)cannabinoids Are Not Effective as Antihypertensive Compounds after Chronic Administration: Comparison of Their Effects on Systemic and Pulmonary Hypertension

https://www.mdpi.com/1424-8247/15/9/1119/htm


A review of PEA for neurodegenerative disorders & defects of the brain’s white matter

Palmitoylethanolamide and White Matter Lesions: Evidence for Therapeutic Implications

https://www.mdpi.com/2218-273X/12/9/1191


A review of how the endocannabinoid system helps to control the hormonal & neuronal response to an immune challenge

Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge

https://pubmed.ncbi.nlm.nih.gov/36042978


A review of why targeting the CB2 receptor is a key future of medicine (by Maccarrone et al.)

Recent Advances on Type-2 Cannabinoid (CB2) Receptor Agonists and Their Therapeutic Potential

https://pubmed.ncbi.nlm.nih.gov/36028971


A review of using cannabinoids to treat the orofacial pain of dentistry Cannabinoid Therapeutics in orofacial pain management: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/36082517


A review of working with the endocannabinoid system for ears, nose & throat specialists Endocannabinoid System and the Otolaryngologist https://pubmed.ncbi.nlm.nih.gov/36088164


In gingival fibroblasts (the stem cells of your gums), CBD, CBG & CBDV had a range of anti-inflammatory & pro-inflammatory activities

Phytocannabinoids regulate inflammation in IL-1β-stimulated human gingival fibroblasts

https://pubmed.ncbi.nlm.nih.gov/36070347