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Research Roundup: Oct 18, 2021



Best of the Week...


A review of CBD for brain disorders

The (Poly)Pharmacology of Cannabidiol in Neurological and Neuropsychiatric Disorders: Molecular Mechanisms and Targets

https://pubmed.ncbi.nlm.nih.gov/34062987/

This reviews looks at the use of cannabinoids – including CBD – against respiratory diseases

The potential of cannabinoids and inhibitors of endocannabinoid degradation in respiratory diseases

https://pubmed.ncbi.nlm.nih.gov/34648805/

In lung cells attacked by the SARS-CoV2 virus (which causes COVID-19), THC & CBD acted as inhibitors in a dual-action manner

Activity of THC, CBD, and CBN on Human ACE2 and SARS-CoV1/2 Main Protease to Understand Antiviral Defense Mechanism

https://pubmed.ncbi.nlm.nih.gov/34638139/

In cells, CBD inhibits the toxicity & inflammation of an attack by the SARS-CoV2 spike & protects the cells via control of genetic transcription

Cannabidiol inhibits SARS-Cov-2 spike (S) protein-induced cytotoxicity and inflammation through a PPARγ-dependent TLR4/NLRP3/Caspase-1 signaling suppression in Caco-2 cell line

https://pubmed.ncbi.nlm.nih.gov/34643000/

This review by a physician highlights the efficacy of CBD - and small amounts of THC – against chronic pain

Oral Cannabidiol (CBD) for the treatment of non-cancer chronic pain

https://digitalshowcase.lynchburg.edu/dmscjournal/vol3/iss4/2/

In skin stem cells from psoriasis patients, the application of CBD restored levels of protective enzymes, lowered inflammation from UVB radiation & protected healthy skin stem cells

Cannabidiol Decreases Metalloproteinase Activity and Normalizes Angiogenesis Factor Expression in UVB-Irradiated Keratinocytes from Psoriatic Patients

https://www.hindawi.com/journals/omcl/2021/7624389/

In a mouse model of alcoholism combined with poor eating habits, CBD prevented fattiness of the liver, lowered oxidative stress & suppressed activation of the pathway causing cell death via inflammation

CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome-Pyroptosis Pathway

https://pubmed.ncbi.nlm.nih.gov/34630100/

In a mouse model of autism, long-term treatment with CBD-rich medical cannabis oil lessened anxiety & repetitive behaviors

Behavioral aspects and neurobiological properties underlying medical cannabis treatment in Shank3 mouse model of autism spectrum disorder

https://pubmed.ncbi.nlm.nih.gov/34645786/


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

This review of the nuclear receptors that regulate genetic transcription has a focus on the PEA found in our CV Defense

Repurposing Peroxisome Proliferator-Activated Receptor Agonists in Neurological and Psychiatric Disorders

https://www.mdpi.com/1424-8247/14/10/1025/htm

CBD also interacts with the PPARs. That’s why in some cell types, CBD can turn on & off hundreds of different genes. So no wonder all these molecules are so tricky to study.

This review of epilepsy medications finds that CBD has no negative effects on sleep architecture or daytime sleepiness

Effects of anti-seizure medications on sleep architecture and daytime sleepiness in patients with epilepsy: A literature review

https://www.sciencedirect.com/science/article/abs/pii/S1087079221001441

This lecture transcript covers the deep amount of research on how the endocannabinoid system regulates early brain development

Physiological Rules of Endocannabinoid Action During Fetal and Neonatal Brain Development

https://pubmed.ncbi.nlm.nih.gov/34619043/

This review covers the functions of the endocannabinoid in the male reproductive system of mammals

Diverse role of endocannabinoid system in mammalian male reproduction

https://pubmed.ncbi.nlm.nih.gov/34637799/



Preclinical Research & Cannabinoid Chemistry

In mice with no CB1 receptor, researchers found that the CB1 receptor helped the smooth muscle of the heart to relax during its dilation phase & that during an infarct (a small area of dead tissue due to lack of blood flow), mice with no CB1 receptors had larger areas of dead tissue

Impaired vessel relaxation response and increased infarct size in smooth muscle cannabinoid receptor 1 knockout mice

https://pubmed.ncbi.nlm.nih.gov/34655603/

All of this dovetails with the common idea that the endocannabinoid system is not involved in the everyday functioning of the heart – but that it’s called upon when the heart is in trouble. See our CVResearch heart page for more info.

In cows with no shortage of food, the injection of anandamide or 2-AG increased food intake in the short term – but only levels of anandamide accumulated in the blood

A Role for Peripheral Anandamide and 2-Arachidonoylglycerol in Short-Term Food Intake and Orexigenic Hypothalamic Responses in a Species with Continuous Nutrient Delivery

https://www.mdpi.com/2072-6643/13/10/3587/htm

In brain cells, the endocannabinoids help to regulate excitability via potassium channels

Endocannabinoids tune intrinsic excitability in O-LM interneurons by direct modulation of post-synaptic Kv7 channels

https://pubmed.ncbi.nlm.nih.gov/34620719/