Best of cannabinoid science this week...
A review of CBD for epilepsy, multiple sclerosis & Parkinson's disease A literature review on the therapeutic applicability of cannabidiol in epilepsy, multiple sclerosis and Parkinson’s disease https://d197for5662m48.cloudfront.net/documents/publicationstatus/156076/preprint_pdf/36263b65c685df2431792402943bc98f.pdf
For anorexia nervosa, a review of eight studies found altered endocannabinoid profiles as well as some benefits from cannabinoids but also some harms The relationship between cannabis and anorexia nervosa: a scoping review https://pubmed.ncbi.nlm.nih.gov/37858278/
A review on treating chronic wounds with cannabinoids Chronic wound-related pain, wound healing and the therapeutic potential of cannabinoids and endocannabinoid system modulation https://pubmed.ncbi.nlm.nih.gov/37865988/
A review of cannabinoids for neuropathic pain Applications of Cannabinoids in Neuropathic Pain: An Updated Review https://pubmed.ncbi.nlm.nih.gov/37824417/
On CBDV helping to modulate neurogenesis Unravelling a novel role for cannabidivarin in the modulation of subventricular zone postnatal neurogenesis https://pubmed.ncbi.nlm.nih.gov/37802277/
In rat cerebellums (voluntary movement & motor skills), THC exposure showed both neuroprotective & neurodegenerative properties Exposure to Δ9-tetrahydrocannabinol leads to a rise in caspase-3, morphological changes in microglial, and astrocyte reactivity in the cerebellum of rats https://academic.oup.com/toxres/advance-article-abstract/doi/10.1093/toxres/tfad098/7323077?redirectedFrom=fulltext
In a mouse model of Alzheimer's disease, a low-dose combination of CBD & THC improved spatial memory while THC-only treatment increased anxiety & depressant like behavior Effects of Chronic, Low-Dose Cannabinoids, Cannabidiol, Delta-9-Tetrahydrocannabinol and a Combination of Both, on Amyloid Pathology in the 5xFAD Mouse Model of Alzheimer's Disease https://pubmed.ncbi.nlm.nih.gov/37862567/
In a rat model of diabetes, the terpene beta caryophyllene improved glycemia control via enhancing glucose absorption & oxidation in the skeletal muscle Effect of β-Caryophyllene on oxidative stress, glucose metabolism in the skeletal muscle of high fat diet and fructose-induced type-2 diabetic adult male rats https://pubmed.ncbi.nlm.nih.gov/37822828/
In rat adults & breastfeeding babies, how THC & CBD moved through their systems
The Effect of Route of Administration and Vehicle on the Pharmacokinetics of THC and CBD in Adult, Neonate, and Breastfed Sprague-Dawley Rats
https://pubmed.ncbi.nlm.nih.gov/37852006/
In a mouse model of non-alcoholic fatty liver disease, feeding them krill oil helped better than other unsaturated fatty acids via modulation of the CB1 receptor pathway n-3 polyunsaturated fatty acids in phospholipid or triacylglycerol form attenuate nonalcoholic fatty liver disease via mediating cannabinoid receptor 1/adiponectin/ceramide pathway https://pubmed.ncbi.nlm.nih.gov/37866428/
A computer investigation of whether cannabinoids bind to the P2X purinoceptor 4 ion channel (related to neuropathic pain, neuroinflammation & neurodegenerative diseases)
Investigating cannabinoids as P2X purinoreceptor 4 ligands by using surface plasmon resonance and computational docking