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Research Roundup: May 30, 2022



Best of cannabinoid science this week...


How PEA helps to inhibit SARS-CoV-2: causes a 70% drop in viral infection by binding to a key protein + dismantles the lipid droplets that the virus uses as an energy source Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor https://pubmed.ncbi.nlm.nih.gov/35632821


In a rat model of temporal lobe epilepsy, PEA reduced the amount of neurodestruction & helped to retain healthy behaviors Neuroprotective Effect of Palmitoylethanolamide in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy https://link.springer.com/article/10.1134/S0022093022020132


A study of cancer patients found medical cannabis helpful for a range of their symptoms (hattip to Stuart Tomc) The Effectiveness and Safety of Medical Cannabis for Treating Cancer Related Symptoms in Oncology Patients https://www.frontiersin.org/articles/10.3389/fpain.2022.861037/full


The great Dr. Donald Abrams with a new clinical study on cannabis helping diabetics with their neuropathic pain Cannabis Ameliorates Diabetic Neuropathy Pain https://www.naturalmedicinejournal.com/journal/cannabis-ameliorates-diabetic-neuropathy-pain

In a cellular model of a wound in your gum, hemp extracts & CBD decreased inflammatory factors & significantly improved wound closure Anti-inflammation and gingival wound healing activities of Cannabis sativa L. subsp. sativa (hemp) extract and cannabidiol: An in vitro study https://pubmed.ncbi.nlm.nih.gov/35623115

This review suggests the possibility of using cannabinoids for wound care Evidence-based Potential Therapeutic Applications of Cannabinoids in Wound Management https://pubmed.ncbi.nlm.nih.gov/35588193

A survey of why people use cannabis for exercise How and why adults use cannabis during physical activity https://pubmed.ncbi.nlm.nih.gov/35585648 “The most frequently reported modes of exercise included hiking (60%), yoga (58%), and aerobic machines (50%). The primary reasons for using cannabis before exercise were "helping to focus/concentrate" (66%), "helping enjoy the exercise experience" (65%), and "enhancing mind-body-spirit connection" (65%).”

In a study of driving, vaporizing low THC/high CBD products caused no effects on driving-related ability Effect of vaporizing cannabis rich in cannabidiol on cannabinoid levels in blood and on driving ability a randomized clinical trial https://assets.researchsquare.com/files/rs-1027611/v1/864b3c69-111d-465e-a992-b0b79b435239.pdf

In human colorectal cancer cells, CBD caused cell cycle arrest, repressed cell viability & induced apoptosis (cellular suicide) via the CB2 receptor Cannabidiol exerts anti-proliferative activity via a cannabinoid receptor 2-dependent mechanism in human colorectal cancer cells https://pubmed.ncbi.nlm.nih.gov/35598400 “Anti-proliferative activity was also observed for other non-psychoactive cannabinoid derivatives including cannabidivarin (CBDV), cannabigerol (CBG), cannabicyclol (CBL), and cannabigerovarin (CBGV).”

A survey of couple functioning & relationship conflict skills among cannabis users finds that they tend to be more avoidant during conflict, have less effective behavioral recovery after conflict & to have a more positive view of their relationship functioning compared to independent raters’ reports Relationship Perceptions and Conflict Behavior among Cannabis Users https://www.sciencedirect.com/science/article/abs/pii/S0376871622002393