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Research Roundup: May 30, 2022

Best of cannabinoid science this week...

How PEA helps to inhibit SARS-CoV-2: causes a 70% drop in viral infection by binding to a key protein + dismantles the lipid droplets that the virus uses as an energy source Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor

In a rat model of temporal lobe epilepsy, PEA reduced the amount of neurodestruction & helped to retain healthy behaviors Neuroprotective Effect of Palmitoylethanolamide in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy

A study of cancer patients found medical cannabis helpful for a range of their symptoms (hattip to Stuart Tomc) The Effectiveness and Safety of Medical Cannabis for Treating Cancer Related Symptoms in Oncology Patients

The great Dr. Donald Abrams with a new clinical study on cannabis helping diabetics with their neuropathic pain Cannabis Ameliorates Diabetic Neuropathy Pain

In a cellular model of a wound in your gum, hemp extracts & CBD decreased inflammatory factors & significantly improved wound closure Anti-inflammation and gingival wound healing activities of Cannabis sativa L. subsp. sativa (hemp) extract and cannabidiol: An in vitro study

This review suggests the possibility of using cannabinoids for wound care Evidence-based Potential Therapeutic Applications of Cannabinoids in Wound Management

A survey of why people use cannabis for exercise How and why adults use cannabis during physical activity “The most frequently reported modes of exercise included hiking (60%), yoga (58%), and aerobic machines (50%). The primary reasons for using cannabis before exercise were "helping to focus/concentrate" (66%), "helping enjoy the exercise experience" (65%), and "enhancing mind-body-spirit connection" (65%).”

In a study of driving, vaporizing low THC/high CBD products caused no effects on driving-related ability Effect of vaporizing cannabis rich in cannabidiol on cannabinoid levels in blood and on driving ability a randomized clinical trial

In human colorectal cancer cells, CBD caused cell cycle arrest, repressed cell viability & induced apoptosis (cellular suicide) via the CB2 receptor Cannabidiol exerts anti-proliferative activity via a cannabinoid receptor 2-dependent mechanism in human colorectal cancer cells “Anti-proliferative activity was also observed for other non-psychoactive cannabinoid derivatives including cannabidivarin (CBDV), cannabigerol (CBG), cannabicyclol (CBL), and cannabigerovarin (CBGV).”

A survey of couple functioning & relationship conflict skills among cannabis users finds that they tend to be more avoidant during conflict, have less effective behavioral recovery after conflict & to have a more positive view of their relationship functioning compared to independent raters’ reports Relationship Perceptions and Conflict Behavior among Cannabis Users


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