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Research Roundup: June 13, 2022



Best of cannabinoid science this week...


A survey of podiatry doctors finds that they think CBD is helpful for foot pain problems Podiatric Physician Perspective on the use of Cannabidiol (CBD) in the Treatment of Foot and Ankle Pathology https://webassets.westernu.edu/web/cpm/journals/extremitas-journal-2022.pdf#page=112


In drivers, CBD (up to 1500 mg) appears to have no negative effects on driving performance or cognitive function Effects of cannabidiol on simulated driving and cognitive performance: A dose-ranging randomised controlled trial https://pubmed.ncbi.nlm.nih.gov/35637624 In a human lung cell & mouse model of a cytokine storm (a symptom of COVID-19), high CBD extracts reduced the levels of pro-inflammatory cytokines, inhibited activation of the T cells & downregulated the cytokine storm High-CBD Extract (CBD-X) Downregulates Cytokine Storm Systemically and Locally in Inflamed Lungs https://pubmed.ncbi.nlm.nih.gov/35651623 A review of the potential of the cannabinoids for helping with chronic inflammatory diseases of the GI tract Involvement of the cannabinoid system in chronic inflammatory intestinal diseases: opportunities for new therapies https://pubmed.ncbi.nlm.nih.gov/35645322 In women with endometriosis, the lesions on their ovaries showed much higher levels of the CB1 & CB2 receptors, suggesting those receptors as targets for treating the pain Detection of Cannabinoid Receptor Expression by Endometriotic Lesions in Women with Endometriosis as an Alternative to Opioid-Based Pain Medication https://www.hindawi.com/journals/jir/2022/4323259 In a tissue study, PEA protects heart cells from the toxicity & inflammation of anti-cancer treatments The analgesic compound palmitoylethanolamide reduces inflammation in human cardiomyocytes and vascular endothelial cells exposed to doxorubicin and anti-HER2 monoclonal antibody through PPAR-α and NLRP3-related pathways https://ascopubs.org/doi/abs/10.1200/JCO.2022.40.16_suppl.e24054 In two liver cancer cell lines, CBD high extracts arrested the cell cycle & significantly induced cell death via mitochondria-dependent apoptosis (suicide via the cell’s power source) Extracellular vesicles of cannabis with high CBD content induce anticancer signaling in human hepatocellular carcinoma https://pubmed.ncbi.nlm.nih.gov/35667235 In dogs with atopic dermatitis (red itchy skin), a CBD/CBDA oil helped with their itchiness but not their lesions The effect of a mixed cannabidiol and cannabidiolic acid based oil on client-owned dogs with atopic dermatitis https://pubmed.ncbi.nlm.nih.gov/35644533 In a meta-analysis covering 1,132 rodents in a model of depression, “cannabinoid administration moderately improved the pooled negative effects of chronic unpredictable stress on anhedonia [inability to feel pleasure], learned helplessness, novelty suppressed feeding, time in the anxiogenic [anxiety-producing] context, and entries into the anxiogenic context” The antidepressant and anxiolytic effects of cannabinoids in chronic unpredictable stress: a preclinical systematic review and meta-analysis https://pubmed.ncbi.nlm.nih.gov/35641487