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Research Roundup: July 4, 2023



Best of cannabinoid science this week...


In insomnia patients, a single dose of 10 mg THC/200 mg CBD significantly decreased the time to sleep & time spent in REM sleep, increased the time until REM sleep occurred, caused changes in brain scan patterns & resulted in no negative next day effects Acute effects of cannabinoids in insomnia disorder: a randomised, placebo-controlled trial using high-density EEG https://academic.oup.com/sleep/article/46/Supplement_1/A164/7182109


In a survey of cancer survivors, one in four report regularly using cannabis to improve their sleep A Cross-Sectional Survey of Cannabis as a Sleep Aid in Canadian Cancer Survivors https://academic.oup.com/sleep/article/46/Supplement_1/A374/7182321


In patients with severe Tourette syndrome, treatment with THC & CBD reduced tics as well as impairments due to tics, anxiety & obsessive compulsive disorder Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome https://evidence.nejm.org/doi/pdf/10.1056/EVIDoa2300012


In two clinical trials of people with multiple sclerosis, nabiximol sprays (1:1 THC:CBD) improved their spasticity scores over 12 weeks Efficacy of nabiximols oromucosal spray on spasticity in people with multiple sclerosis: Treatment effects on Spasticity Numeric Rating Scale, muscle spasm count, and spastic muscle tone in two randomized clinical trials https://pubmed.ncbi.nlm.nih.gov/37209500/


In sarcopenia (a debilitating skeletal muscle disease of the elderly), a suggestion for the use of PEA Linking Endocannabinoid System, Palmitoylethanolamide and Sarcopenia in view of therapeutic outcomes https://iris.unimore.it/handle/11380/1306346


A review of the clinical data for CBD

Current state of knowledge on the use of cannabidiol (CBD) in various medical conditions


For multiple sclerosis, a review of the data from preclinical to clinical

Cannabis and Cannabinoids in Multiple Sclerosis: From Experimental Models to Clinical Practice-A Review


A review of 23 studies on how the cannabinoids alter the output of the spinal motor neurons

The effects of cannabinoids on spinal motor neuron output


In public health data on children whose mothers use cannabis prenatally, they had no differences in their neuropsychological scores or autistic traits from those whose mothers did not use cannabis Neurodevelopmental outcomes in children after prenatal marijuana exposure https://pubmed.ncbi.nlm.nih.gov/37283466/


In a mouse model of Dravet syndrome (a severe childhood epilepsy), superior results were obtained when combining CBD & β-caryophyllene (one of the most cannabis terpenes) then when using them separately in terms of inflammation, behavioral disturbances & brain immune cell reactivities

Disease-modifying effects of cannabidiol, β-caryophyllene and their combination in Syn1-Cre/Scn1aWT/A1783V mice, a preclinical model of Dravet syndrome

In hamsters, using probiotics improve the gut microbiota & the endocannabinoidome Probiotic interventions promote metabolic health in high fat-fed hamsters in association with gut microbiota and endocannabinoidome alterations https://pubmed.ncbi.nlm.nih.gov/37282555/


On the positive effects of using cannabis ethanol extracts for gastrointestinal disorders

Investigation on the gastrointestinal properties of ethanolic extract of Cannabis sativa through in vivo and in vitro approaches


In astrocytes (brain support cells), the CB1 receptors help to mediate stress response & antidepressant effects via protection of the blood brain-barrier from alterations Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood-brain barrier alterations https://assets.researchsquare.com/files/rs-2978353/v1_covered_5e46ce79-9ebb-4f5e-925c-f6c5d0c7cbda.pdf?c=1685681284

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