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Research Roundup: July 19, 2021



Best of the Week...


In humans, taking your CBD after a fatty meal helps with absorption

The Effects of Food on Cannabidiol Bioaccessibility

https://pubmed.ncbi.nlm.nih.gov/34208082/


This review of clinical trials finds that CBD helps to decrease appetite

Approved cannabinoids for medical purposes - Comparative systematic review and meta-analysis for sleep and appetite

https://pubmed.ncbi.nlm.nih.gov/34181977/


An elephant in Mexico was successfully treated with CBD for its abscesses & lack of appetite

Preliminary Evaluation of Cannabidiol Use in an Asian Elephant: Brief Report

https://www.preprints.org/manuscript/202106.0442/v1


In humans, PEA as well as the flavonoid luteolin helped to recover the sense of smell after a COVID infection

Randomized clinical trial "olfactory dysfunction after COVID-19: olfactory rehabilitation therapy vs. intervention treatment with Palmitoylethanolamide and Luteolin": preliminary results

https://pubmed.ncbi.nlm.nih.gov/34156697/


In children with epilepsy & autism, Zynerba’s CBD transdermal gel helped with sleep

Impact of ZYN002 Cannabidiol Transdermal Gel on Sleep in Children and Adolescents With Developmental and Epileptic Encephalopathies and Comorbid Autism Spectrum Disorder

https://zynerba.com/wp-content/uploads/2021/06/2021-SLEEP_ZYN2-CL-025-BELIEVE-ASD-Sleep-Data_03June2021_Final-for-Submission.pdf


A survey of families with CDKL5 (a genetic disorder leading to early seizures) reports that they find cannabis & CBD products to be helpful

The perceived effects of cannabis products in the management of seizures in CDKL5 Deficiency Disorder

https://pubmed.ncbi.nlm.nih.gov/34148781/


In lung cells, CBD potently lowered replication of SARS-CoV-2 (this paper is not peer-reviewed – so be even more cautious with its results)

Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response

https://pubmed.ncbi.nlm.nih.gov/33758843/


This review highlights the many parts of the ECS that can be targeted to treat depression

Molecular Targets of Cannabinoids Associated with Depression

https://pubmed.ncbi.nlm.nih.gov/34165403/


In a rat model of Parkinson’s disease, CBD helped with their musculoskeletal pain

Cannabidiol has therapeutic potential for myofascial pain in female and male parkinsonian rats

https://pubmed.ncbi.nlm.nih.gov/34246682/


A study in tissues supports CBD’s anti-diabetic effects

Evaluation of cannabidiol's inhibitory effect on alpha-glucosidase and its stability in simulated gastric and intestinal fluids

https://pubmed.ncbi.nlm.nih.gov/34162444/


In rats exposed to THC, CBD blocked the anxiety-producing effects & enhanced the anxiety-reliving effects

Female but not male rats show biphasic effects of low doses of Δ 9-tetrahydrocannabinol on anxiety: can cannabidiol interfere with these effects?

https://pubmed.ncbi.nlm.nih.gov/34181978/


In a mouse model of fetal alcohol syndrome, CBD protected the brain from cognitive deficits & neuroinflammation

Cannabidiol attenuates cognitive deficits and neuroinflammation induced by early alcohol exposure in a mice model

https://pubmed.ncbi.nlm.nih.gov/34126352/


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

This survey of Canadian cannabis clinics found CBD helped for pain, anxiety & depression in moderate & severe cases but not mild cases

Cannabidiol use and effectiveness: real-world evidence from a Canadian medical cannabis clinic

https://pubmed.ncbi.nlm.nih.gov/34162446/


In mice, ketamine & CBD combined to increase their antidepressant effects

Co-administration of cannabidiol and ketamine induces antidepressant-like effects devoid of hyperlocomotor side-effects

https://pubmed.ncbi.nlm.nih.gov/34157363/

popular article: Project CBD on the antidepressant effects of CBD & ketamine

https://www.projectcbd.org/science/real-world-cbd-evidence-cbd-and-ketamine-and-more


In brain scans of human with autism, CBDV caused the striatum of the brain to move towards more neurotypical functionality

Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin

https://pubmed.ncbi.nlm.nih.gov/34210360/


In humans, genetic differences in their CB1 receptors & FAAH enzymes showed that they are involved in forgetting fears

Cannabinoid polymorphisms interact with plasma endocannabinoid levels to predict fear extinction learning

https://pubmed.ncbi.nlm.nih.gov/34151472/


A review of using cannabinoids to treat opiate addiction

Cannabinoid treatment of opiate addiction

https://www.psycharchives.org/bitstream/20.500.12034/4327/1/nab.2021.e14.pdf


This review looks at the ECS in urology & male reproductive health

The endocannabinoid system, cannabis, and cannabidiol: Implications in urology and men's health

https://pubmed.ncbi.nlm.nih.gov/34168527/


This review looks at how CB1 receptors regulate astrocytes (key players in the homeostasis of neurons)

CB1R-dependent regulation of astrocyte physiology and astrocyte-neuron interactions

https://pubmed.ncbi.nlm.nih.gov/34157362/


A review of targeting the ECS for treating schizophrenia

The endocannabinoid system as a therapeutic target for schizophrenia: Failures and potentials

https://pubmed.ncbi.nlm.nih.gov/34146641/

Preclinical Research & Cannabinoid Chemistry

In hair cells, CBD may be a treatment for the hormonal imbalances & excess signaling of alopecia (patchy hair loss)

Regulatory Effect of Cannabidiol (CBD) on Decreased β-Catenin Expression in Alopecia Models by Testosterone and PMA Treatment in Dermal Papilla Cells

https://pubmed.ncbi.nlm.nih.gov/34249397/


In a rat model of myocardial ischemia reperfusion (the return of blood flow to the heart after a heart attack), pretreatment with CBD protected the heart from damage

Cannabidiol-mediated RISK PI3K/AKT and MAPK/ERK pathways decreasing reperfusion myocardial damage

https://pubmed.ncbi.nlm.nih.gov/34176244/


In mice, CBD prevented several behavioral symptoms of cocaine addiction & may help to prevent the development of addiction or the likelihood to relapse

Cannabidiol prevents several of the behavioral alterations related to cocaine addiction in mice

https://pubmed.ncbi.nlm.nih.gov/34157334/


In zebrafish, CBD oil had little impact on the microbiome

Passive exposure to cannabidiol oil does not cause microbiome dysbiosis in larval zebrafish

https://www.sciencedirect.com/science/article/pii/S2666517421000262


In a mouse model of Dravet Syndrome, CBD & clonazepam combined well to reduce seizure duration

Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome

https://www.scientificarchives.com/admin/assets/articles/pdf/combined-antiseizure-efficacy-of-cannabidiol-and-clonazepam-in-a-conditional-mouse-model-of-dravet-syndrome-20210618110636.pdf


In rats with spinal cord injuries, activating the CB2 receptor helped mitigate their osteoporosis

Delayed Systemic Treatment with Cannabinoid Receptor 2 Agonist Mitigates Spinal Cord Injury-Induced Osteoporosis More Than Acute Treatment Directly after Injury

https://pubmed.ncbi.nlm.nih.gov/34223557/


In mice disoriented by an anesthetic, activating the CB2 receptor protects their brain & behavior via changes in hippocampal neuroinflammation, neurogenesis & neuroplasticity

Cannabinoid receptor 2 deficiency enhances isoflurane-induced spatial cognitive impairment in adult mice by affecting neuroinflammation, neurogenesis and neuroplasticity

https://pubmed.ncbi.nlm.nih.gov/34257720/


In rats, the ECS & the dopamine system are linked to the changes associated with obesity

The endocannabinoid system is modulated in reward and homeostatic brain regions following diet-induced obesity in rats: a cluster analysis approach

https://pubmed.ncbi.nlm.nih.gov/34165614/


In a mouse with no CB1 receptors, researchers looked at changes in social behavior & communication with relevance to autism

Communication and social interaction in the cannabinoid-type 1 receptor null mouse: Implications for autism spectrum disorder

https://pubmed.ncbi.nlm.nih.gov/34173729/


In rats treated with low levels of electricity to control convulsions, the ECS helps to improve learning & memory

Low-Frequency Stimulation Prevents Kindling-Induced Impairment through the Activation of the Endocannabinoid System

https://pubmed.ncbi.nlm.nih.gov/34222471/


In brain tissue, CB1 receptors on the mitochondria (the powerhouse of the cell) regulates the calcium signaling of the brain’s astrocytes

ER-mitochondria contacts underline cannabinoid regulation of calcium signaling in astrocytes

https://europepmc.org/article/ppr/ppr357782


In female mice with no CB1 receptor, a high-fat diet caused their offspring to be susceptible to later metabolic challenges

MATERNAL OBESITY REVERSES THE RESISTANCE TO LPS-INDUCED ADVERSE PREGNANCY OUTCOME AND INCREASES FEMALE OFFSPRING METABOLIC ALTERATIONS IN CANNABINOID RECEPTOR 1 KNOCKOUT MICE

https://pubmed.ncbi.nlm.nih.gov/34147601/


In mice with no DAGL-β enzyme (which creates 2-AG), they had less neuroinflammation during traumatic brain injury & displayed gender differences

Diacylglycerol Lipase-β Knockout Mice Display a Sex-Dependent Attenuation of Traumatic Brain Injury-Induced Mortality with No Impact on Memory or Other Functional Consequences

https://pubmed.ncbi.nlm.nih.gov/34142866/