Best of cannabinoid science this week...
In small trial of people with insomnia, 150 milligrams of CBD improved their well-being scores as well as their sleep efficiency after 2 weeks of treatment
Cannabidiol for moderate-severe insomnia: a randomized controlled pilot trial of 150 mg of nightly dosing
A survey finds farmers interested in using cannabis for treating chronic pain
An Assessment of Farmers' Perspectives of Medical Marijuana as an Alternative Treatment for Chronic Pain: A Survey
In mature horses with osteoarthritis, a 15% CBD paste reduced pain & inflammation as well as improving health
Improved quality of life and pain relief in mature horses with osteoarthritis after oral transmucosal cannabidiol oil administration as part of an analgesic regimen
For chronic pain, a review of 90 trials finds cannabis to have similar efficacy to opioids with fewer discontinuations due to side effects
Cannabis for medical use versus opioids for chronic non-cancer pain: a systematic review and network meta-analysis of randomised clinical trials
A review of using CBD for vascular diseases such as “atherosclerosis, stress-induced hypertension, diabetes-related vasculopathy, ischemia-reperfusion injury, and vascular damage caused by smoking and alcohol abuse” (nice chart)
Research progress in the management of vascular disease with cannabidiol: a review
In a rat model of exhaustive exercise training, CBD protected the skeletal muscle from damage via the mitochondria (powerhouse of the cell)
Cannabinoids improve mitochondrial function in skeletal muscle of exhaustive exercise training rats by inhibiting mitophagy through the PINK1/PARKIN and BNIP3 pathways
In a mouse model of colitis, dietary CBD lessened their chronic inflammation & leaky guts via the PKA/AMPK pathway
Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis Mice
In a mouse model of nicotine addiction, CBD lessened the signs of withdrawal as well as nicotine’s pain-sensitivity inducing effects
Cannabidiol as a potential cessation therapeutic: Effects on intravenous nicotine self-administration and withdrawal symptoms in mice
In a skin tissue model of psoriasis, CBD cause anti-inflammation via the T-cells
Cannabidiol Mediates In Vitro Attenuation of Proinflammatory Cytokine Responses in Psoriatic Disease
In a rat model of memory consolidation, CBD worked well with valproate to consolidate memories
Role of hippocampal and prefrontal cortical cholinergic transmission in combination therapy valproate and cannabidiol in memory consolidation in rats: involvement of CREB- BDNF signaling pathways
In a mouse model of pain, oxycodone combined well with THC for painkilling effects as well as delaying the formation of tolerance and without the THC augmenting the negatives of the oxycodone (except for its rewarding properties)
Impact of Δ9-Tetrahydrocannabinol and oxycodone co-administration on measures of antinociception, dependence, circadian activity, and reward in mice
In a mouse model of pain, negative allosteric modulation of the CB1 receptor (a function of CBD) allowed opioid painkillers to work while lowering the development of tolerance to them & their withdrawal symptoms
Negative allosteric modulation of cannabinoid CB 1 receptor signaling suppresses opioid-mediated tolerance and withdrawal without blocking opioid antinociception
In a mouse model of inflammatory pain, CBD combined well with the tricyclic antidepressant amitriptyline to lower pain levels via the serotonin 1A receptors
Assessing Dose- and Sex-Dependent Antinociceptive Effects of Cannabidiol and Amitriptyline, Alone and in Combination, and Exploring Mechanism of Action Involving Serotonin 1A Receptors
In a frog model of the GI tract, CBD tightened gastric tight junctions & improved the gastric barrier function
Cannabidiol Strengthening of Gastric Tight Junction Complexes Analyzed in an Improved Xenopus Oocyte Assay
A giant list of the 6,000+ chemical constituents in commercial cannabis (available in a centralized, open-access database)
Chemical Composition of Commercial Cannabis