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Research Roundup: Dec 13, 2021



Best of the Week...


2018: In regular cannabis users, 200 mg of CBD per day caused less depressive & psychotic symptoms as well as improved scores in attentional switching, verbal learning & memory

Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial

https://pubmed.ncbi.nlm.nih.gov/29607408/

The combination of several clinical trials shows that CBD & PEA skin products are nonirritating & nonsensitizing for the skin

Tolerability profile of topical cannabidiol and palmitoylethanolamide: a compilation of single-centre randomized evaluator-blinded clinical and in vitro studies in normal skin

https://pubmed.ncbi.nlm.nih.gov/34022073/

A review of studies using cannabinoids for pain found “THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain”

Efficacy of cannabis-based medications compared to placebo for the treatment of chronic neuropathic pain: a systematic review with meta-analysis

https://pc.jdapm.org/DOIx.php?id=10.17245/jdapm.2021.21.6.479

In a mouse model of PTSD & aversive memories, this study looks at how CBD works in the brain

Medial prefrontal cortex mechanisms of cannabidiol-induced aversive memory reconsolidation impairments

https://pubmed.ncbi.nlm.nih.gov/34864001/

In a mouse model of seizures, hemp extract with CBD & terpenes worked the best

Antiseizure Effects of Fully Characterized Non-Psychoactive Cannabis sativa L. Extracts in the Repeated 6-Hz Corneal Stimulation Test

https://www.mdpi.com/1424-8247/14/12/1259

2020: In a mouse model of Alzheimer’s disease, CBD reduced their memory deficits for object recognition

Medium-Dose Chronic Cannabidiol Treatment Reverses Object Recognition Memory Deficits of APP Swe /PS1ΔE9 Transgenic Female Mice

https://pubmed.ncbi.nlm.nih.gov/33424597/


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

This review looks at 18 studies showing how cannabinoids & resveratrol help with neuroprotection in Parkinson’s disease

The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies

https://www.mdpi.com/2076-3425/11/12/1573

This review looks at the safety of CBD in treating epilepsy in children

Efficacy and safety of medical cannabinoids in children: a systematic review and meta-analysis

https://pubmed.ncbi.nlm.nih.gov/34873203/

Dr. Piomelli on using cannabinoids for the treatment of the adverse effects of cancer chemotherapy

Cannabinoids and Cancer Chemotherapy-Associated Adverse Effects

https://pubmed.ncbi.nlm.nih.gov/34850893/

A review of using cannabinoids to treat fibromyalgia

A Systematic Review of Fibromyalgia and Recent Advancements in Treatment: Is Medicinal Cannabis a New Hope?

https://www.researchgate.net/publication/354036565_A_Systematic_Review_of_Fibromyalgia_and_Recent_Advancements_in_Treatment_Is_Medicinal_Cannabis_a_New_Hope

2019: In chronic pain patients with fibromyalgia, the complicated pharmacokinetics of THC & CBD for pain reduction

An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia

https://pubmed.ncbi.nlm.nih.gov/30585986/

A review of using the cannabinoids for chronic neuropathic pain

Cannabis-Based Medicines and Medical Cannabis for Chronic Neuropathic Pain

https://pubmed.ncbi.nlm.nih.gov/34802112/

The research plan for studying the use of cannabinoids for pain

International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia: research agenda on the use of cannabinoids, cannabis, and cannabis-based medicines for pain management

https://pubmed.ncbi.nlm.nih.gov/34138827/

In a survey of cannabis consumers, those who used cannabis tended to report either shorter or longer sleep than average – and even more so for heavy users

Recent cannabis use and nightly sleep duration in adults: a population analysis of the NHANES from 2005 to 2018

https://pubmed.ncbi.nlm.nih.gov/34873024/

If there’s anything unpredictable about cannabis/THC, it’s how it will affect someone’s sleep.

This review looks at the endocannabinoid’s involvement with cancer & the tumor microenvironment

Endocannabinoid System and Tumour Microenvironment: New Intertwined Connections for Anticancer Approaches

https://www.mdpi.com/2073-4409/10/12/3396



Preclinical Research & Cannabinoid Chemistry

In mice with pain, CBD helped more in males than in females – and showed no synergistic effect with morphine

Evaluating the Antinociceptive Efficacy of Cannabidiol Alone or in Combination with Morphine Using the Formalin Test in Male and Female Mice

https://pubmed.ncbi.nlm.nih.gov/34846928/

In mice with memory impairment from the calcium channel blocker verapamil, a blocker of the CB1 receptor (similar to CBD) helps to counter the negative memory effects

The interactive effects of verapamil and CB1 cannabinoid receptor antagonist/inverse agonist, AM251 on passive avoidance learning and memory in rat

https://pubmed.ncbi.nlm.nih.gov/34845169/

In a rat model of sarcopenia (an age-related disease that causes an accelerated loss of muscle mass & function), they saw altered levels of the endocannabinoids & suggest targeting the endocannabinoid system

Alterations of the endocannabinoid system and circulating and peripheral tissue levels of endocannabinoids in sarcopenic rats

https://pubmed.ncbi.nlm.nih.gov/34854262/

In a mouse model of Dravet syndrome, using β-caryophyllene (the most common terpene in the plant & in our products) led to reductions in seizures, improved behavioral activities & reduced glial activity in the associated brain areas

Preclinical investigation of β-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome

https://pubmed.ncbi.nlm.nih.gov/34875285/

In an animal model of osteoarthritis, β-caryophyllene both helped with the pain & reduced cartilage degeneration

Antinociceptive and chondroprotective effects of prolonged β-caryophyllene treatment in the animal model of osteoarthritis: Focus on tolerance development

https://pubmed.ncbi.nlm.nih.gov/34856202/

In a mouse model of diabetes, abnormal cannabidiol (a synthetic isomer) reduces inflammation, preserves islets of the pancreas & delays the progress of insulitis

Abnormal cannabidiol ameliorates inflammation preserving pancreatic beta cells in mouse models of experimental type 1 diabetes and beta cell damage

https://pubmed.ncbi.nlm.nih.gov/34872800/

In a mouse model of itching, activation of the CB1 receptor plus a drug to inhibit the heat shock proteins can be used to reduce the itching

The Effects of the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin, Cannabinoid Agonist WIN 55,212-2, and Nitric Oxide Synthase Inhibitor Nω-Nitro-L-Arginine Methyl Ester Hydrochloride on the Serotonin and Dry Skin-Induced Itch

https://pubmed.ncbi.nlm.nih.gov/34864727/

In rats with heart problems from diabetes, a combination of CB2 activation & L-arginine decreased oxidative stress, reduced inflammation & protected the heart

CB2 receptor agonist and L- arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition

https://pubmed.ncbi.nlm.nih.gov/34860602/