Best of the Week...
2018: In regular cannabis users, 200 mg of CBD per day caused less depressive & psychotic symptoms as well as improved scores in attentional switching, verbal learning & memory
Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial
The combination of several clinical trials shows that CBD & PEA skin products are nonirritating & nonsensitizing for the skin
Tolerability profile of topical cannabidiol and palmitoylethanolamide: a compilation of single-centre randomized evaluator-blinded clinical and in vitro studies in normal skin
A review of studies using cannabinoids for pain found “THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain”
Efficacy of cannabis-based medications compared to placebo for the treatment of chronic neuropathic pain: a systematic review with meta-analysis
In a mouse model of PTSD & aversive memories, this study looks at how CBD works in the brain
Medial prefrontal cortex mechanisms of cannabidiol-induced aversive memory reconsolidation impairments
In a mouse model of seizures, hemp extract with CBD & terpenes worked the best
Antiseizure Effects of Fully Characterized Non-Psychoactive Cannabis sativa L. Extracts in the Repeated 6-Hz Corneal Stimulation Test
2020: In a mouse model of Alzheimer’s disease, CBD reduced their memory deficits for object recognition
Medium-Dose Chronic Cannabidiol Treatment Reverses Object Recognition Memory Deficits of APP Swe /PS1ΔE9 Transgenic Female Mice
Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)
This review looks at 18 studies showing how cannabinoids & resveratrol help with neuroprotection in Parkinson’s disease
The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies
This review looks at the safety of CBD in treating epilepsy in children
Efficacy and safety of medical cannabinoids in children: a systematic review and meta-analysis
Dr. Piomelli on using cannabinoids for the treatment of the adverse effects of cancer chemotherapy
Cannabinoids and Cancer Chemotherapy-Associated Adverse Effects
A review of using cannabinoids to treat fibromyalgia
A Systematic Review of Fibromyalgia and Recent Advancements in Treatment: Is Medicinal Cannabis a New Hope?
2019: In chronic pain patients with fibromyalgia, the complicated pharmacokinetics of THC & CBD for pain reduction
An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia
A review of using the cannabinoids for chronic neuropathic pain
Cannabis-Based Medicines and Medical Cannabis for Chronic Neuropathic Pain
The research plan for studying the use of cannabinoids for pain
International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia: research agenda on the use of cannabinoids, cannabis, and cannabis-based medicines for pain management
In a survey of cannabis consumers, those who used cannabis tended to report either shorter or longer sleep than average – and even more so for heavy users
Recent cannabis use and nightly sleep duration in adults: a population analysis of the NHANES from 2005 to 2018
If there’s anything unpredictable about cannabis/THC, it’s how it will affect someone’s sleep.
This review looks at the endocannabinoid’s involvement with cancer & the tumor microenvironment
Endocannabinoid System and Tumour Microenvironment: New Intertwined Connections for Anticancer Approaches
Preclinical Research & Cannabinoid Chemistry
In mice with pain, CBD helped more in males than in females – and showed no synergistic effect with morphine
Evaluating the Antinociceptive Efficacy of Cannabidiol Alone or in Combination with Morphine Using the Formalin Test in Male and Female Mice
In mice with memory impairment from the calcium channel blocker verapamil, a blocker of the CB1 receptor (similar to CBD) helps to counter the negative memory effects
The interactive effects of verapamil and CB1 cannabinoid receptor antagonist/inverse agonist, AM251 on passive avoidance learning and memory in rat
In a rat model of sarcopenia (an age-related disease that causes an accelerated loss of muscle mass & function), they saw altered levels of the endocannabinoids & suggest targeting the endocannabinoid system
Alterations of the endocannabinoid system and circulating and peripheral tissue levels of endocannabinoids in sarcopenic rats
In a mouse model of Dravet syndrome, using β-caryophyllene (the most common terpene in the plant & in our products) led to reductions in seizures, improved behavioral activities & reduced glial activity in the associated brain areas
Preclinical investigation of β-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome
In an animal model of osteoarthritis, β-caryophyllene both helped with the pain & reduced cartilage degeneration
Antinociceptive and chondroprotective effects of prolonged β-caryophyllene treatment in the animal model of osteoarthritis: Focus on tolerance development
In a mouse model of diabetes, abnormal cannabidiol (a synthetic isomer) reduces inflammation, preserves islets of the pancreas & delays the progress of insulitis
Abnormal cannabidiol ameliorates inflammation preserving pancreatic beta cells in mouse models of experimental type 1 diabetes and beta cell damage
In a mouse model of itching, activation of the CB1 receptor plus a drug to inhibit the heat shock proteins can be used to reduce the itching
The Effects of the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin, Cannabinoid Agonist WIN 55,212-2, and Nitric Oxide Synthase Inhibitor Nω-Nitro-L-Arginine Methyl Ester Hydrochloride on the Serotonin and Dry Skin-Induced Itch
In rats with heart problems from diabetes, a combination of CB2 activation & L-arginine decreased oxidative stress, reduced inflammation & protected the heart
CB2 receptor agonist and L- arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition