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Research Roundup: Dec 13, 2021



Best of the Week...


2018: In regular cannabis users, 200 mg of CBD per day caused less depressive & psychotic symptoms as well as improved scores in attentional switching, verbal learning & memory

Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial

The combination of several clinical trials shows that CBD & PEA skin products are nonirritating & nonsensitizing for the skin

Tolerability profile of topical cannabidiol and palmitoylethanolamide: a compilation of single-centre randomized evaluator-blinded clinical and in vitro studies in normal skin

A review of studies using cannabinoids for pain found “THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain”

Efficacy of cannabis-based medications compared to placebo for the treatment of chronic neuropathic pain: a systematic review with meta-analysis

In a mouse model of PTSD & aversive memories, this study looks at how CBD works in the brain

Medial prefrontal cortex mechanisms of cannabidiol-induced aversive memory reconsolidation impairments

In a mouse model of seizures, hemp extract with CBD & terpenes worked the best

Antiseizure Effects of Fully Characterized Non-Psychoactive Cannabis sativa L. Extracts in the Repeated 6-Hz Corneal Stimulation Test

2020: In a mouse model of Alzheimer’s disease, CBD reduced their memory deficits for object recognition

Medium-Dose Chronic Cannabidiol Treatment Reverses Object Recognition Memory Deficits of APP Swe /PS1ΔE9 Transgenic Female Mice


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

This review looks at 18 studies showing how cannabinoids & resveratrol help with neuroprotection in Parkinson’s disease

The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies

This review looks at the safety of CBD in treating epilepsy in children

Efficacy and safety of medical cannabinoids in children: a systematic review and meta-analysis

Dr. Piomelli on using cannabinoids for the treatment of the adverse effects of cancer chemotherapy

Cannabinoids and Cancer Chemotherapy-Associated Adverse Effects

A review of using cannabinoids to treat fibromyalgia

A Systematic Review of Fibromyalgia and Recent Advancements in Treatment: Is Medicinal Cannabis a New Hope?

2019: In chronic pain patients with fibromyalgia, the complicated pharmacokinetics of THC & CBD for pain reduction

An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia

A review of using the cannabinoids for chronic neuropathic pain

Cannabis-Based Medicines and Medical Cannabis for Chronic Neuropathic Pain

The research plan for studying the use of cannabinoids for pain

International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia: research agenda on the use of cannabinoids, cannabis, and cannabis-based medicines for pain management

In a survey of cannabis consumers, those who used cannabis tended to report either shorter or longer sleep than average – and even more so for heavy users

Recent cannabis use and nightly sleep duration in adults: a population analysis of the NHANES from 2005 to 2018

If there’s anything unpredictable about cannabis/THC, it’s how it will affect someone’s sleep.

This review looks at the endocannabinoid’s involvement with cancer & the tumor microenvironment

Endocannabinoid System and Tumour Microenvironment: New Intertwined Connections for Anticancer Approaches



Preclinical Research & Cannabinoid Chemistry

In mice with pain, CBD helped more in males than in females – and showed no synergistic effect with morphine

Evaluating the Antinociceptive Efficacy of Cannabidiol Alone or in Combination with Morphine Using the Formalin Test in Male and Female Mice

In mice with memory impairment from the calcium channel blocker verapamil, a blocker of the CB1 receptor (similar to CBD) helps to counter the negative memory effects

The interactive effects of verapamil and CB1 cannabinoid receptor antagonist/inverse agonist, AM251 on passive avoidance learning and memory in rat

In a rat model of sarcopenia (an age-related disease that causes an accelerated loss of muscle mass & function), they saw altered levels of the endocannabinoids & suggest targeting the endocannabinoid system

Alterations of the endocannabinoid system and circulating and peripheral tissue levels of endocannabinoids in sarcopenic rats

In a mouse model of Dravet syndrome, using β-caryophyllene (the most common terpene in the plant & in our products) led to reductions in seizures, improved behavioral activities & reduced glial activity in the associated brain areas

Preclinical investigation of β-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome

In an animal model of osteoarthritis, β-caryophyllene both helped with the pain & reduced cartilage degeneration

Antinociceptive and chondroprotective effects of prolonged β-caryophyllene treatment in the animal model of osteoarthritis: Focus on tolerance development

In a mouse model of diabetes, abnormal cannabidiol (a synthetic isomer) reduces inflammation, preserves islets of the pancreas & delays the progress of insulitis

Abnormal cannabidiol ameliorates inflammation preserving pancreatic beta cells in mouse models of experimental type 1 diabetes and beta cell damage

In a mouse model of itching, activation of the CB1 receptor plus a drug to inhibit the heat shock proteins can be used to reduce the itching

The Effects of the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin, Cannabinoid Agonist WIN 55,212-2, and Nitric Oxide Synthase Inhibitor Nω-Nitro-L-Arginine Methyl Ester Hydrochloride on the Serotonin and Dry Skin-Induced Itch

In rats with heart problems from diabetes, a combination of CB2 activation & L-arginine decreased oxidative stress, reduced inflammation & protected the heart

CB2 receptor agonist and L- arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition

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