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Research Roundup: Apr 25, 2022



Best of cannabinoid science this week...


An analysis of Medicaid data shows that cannabis legalization significantly reduced pharmaceutical prescriptions Recreational cannabis legalizations associated with reductions in prescription drug utilization among Medicaid enrollees https://pubmed.ncbi.nlm.nih.gov/35429072/

In dementia patients, a cannabis oil with 30% CBD & 1% THC helped with agitation & aggression Effects of Broad Spectrum Cannabidiol Oil on Behavioral Disturbances in Patients with Dementia: A Randomized Clinical Trial https://assets.researchsquare.com/files/rs-1521853/v1/269f459b-f15e-4535-84b5-c7b5878bc351.pdf?c=1649435492 & this review of Alzheimer’s disease looks at how the endocannabinoids system affects the microglial cells (immune cells of the brain) Microglial Endocannabinoid Signalling in AD https://pubmed.ncbi.nlm.nih.gov/35406803/

In 38 patients with insomnia, cannabis helped 15 of them to reduce or discontinue their sleep medication & 27 reported it helped to improve their sleep Cannabis use in patients with insomnia and sleep disorders: Retrospective chart review https://journals.sagepub.com/doi/abs/10.1177/17151635221089617

In 83 cancer patients, cannabis helped them with pain, nausea, appetitive improvement & reduced anxiety Cannabis for Symptom Clusters in Patients with Advanced Illness: What Is the Evidence? https://www.sciencedirect.com/science/article/abs/pii/S0885392422003645 A review of CBD for mental health with a focus on dampening the inflammasome of the microglial cells (immune cells of the brain) The NLRP3 inflammasome in stress response: another target for the promiscuous cannabidiol? https://pubmed.ncbi.nlm.nih.gov/35410608/ In a small pilot study, a CBD topical combined with retinol helped with a variety of facial skin imperfections A Single-Center Study Evaluating the Effects of a Novel Retinol and Cannabidiol Combination Topical on Facial Skin https://pubmed.ncbi.nlm.nih.gov/35274096/ In a mouse model of PTSD, a comparison of CBD with sertraline (an SSRI) found that CBD reduced the “the consolidation, retrieval, and reconsolidation of trauma-related fear memory” (while sertraline only reduced fear-memory retrieval) & that CBD was effective whether given before, during or after the trauma while sertraline was only effective if given before Comparison between cannabidiol and sertraline for the modulation of post-traumatic stress disorder-like behaviors and fear memory in mice https://pubmed.ncbi.nlm.nih.gov/35396940/ A review of CBD for dogs & horses Cannabidiol and possibilities of its use in veterinary medicine of dogs and horses: A brief review https://www.agriculturejournals.cz/web/vetmed.htm?type=article&id=127_2021-VETMED In a mouse model of anxiety & depression, CBD seemed to help via the CB1 receptor as well as by increasing the genetic expression of GABA & cannabinoid receptors Cannabinoid CB1 Receptor Involvement in the Actions of CBD on Anxiety and Coping Behaviors in Mice https://www.mdpi.com/1424-8247/15/4/473/htm In rats addicted to meth, CBD (but not CBDA) helped them to self-administer less Cannabidiol but not cannabidiolic acid reduces behavioural sensitisation to methamphetamine in rats, at pharmacologically effective doses

https://pubmed.ncbi.nlm.nih.gov/35435462/